Using machine learning to discover candidate localised transcripts from microscopy and genome-wide bioinformatics data by Kiourlappou, M

“…After the production of labels, I present the figures using a novel visualisation tool which allows a user to explore the images alongside with the labels describing localisation for each gene and the different compartments examined for each gene. …”

Computational analysis and prediction of specific genomic regions forming R-loop structure and chromosomal variations associated with cancer by Wongsurawat, Thidathip

“…Integrative genomics analyses suggested that RLFSs could play a role in gene regulation, AID/APOBEC-mediated editing/mutagenesis, alternative splicing, and epigenetic modifications, and also associate with mutations in cancer, neurodegenerative diseases and mental disorders. …”
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Unstoppable Wallets: Chain-assisted Threshold ECDSA and its Applications by Zyskind, Guy, Yanai, Avishay, Pentland, Alex

“…Our protocols minimize the write-complexity for threshold ECDSA key-generation and signing, while reducing communication and computation overhead. We provide a proof-of-concept implementation of these protocols, written in a smart contract language, deployed on the Secret Network - a blockchain that plays the role of the server. …”
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Cardiac-sympathetic dysfunction in hypertension by Bardsley, E

“…This chapter focussed specifically on the role of the sympathetic nervous system as a primary causative factor in the aetiology of hypertension, and presented evidence highlighting a critical role for impaired cyclic nucleotide signalling in sympathetic over-activity.…”

Impact of host gut microbiome on pathogen colonization by Low, Wai Leong

“…Compositional changes in this commensal gut microbiota result in the outgrowth of gut pathogens, but the mechanisms underlying this phenomenon remain largely unexplored. Hence, it would benefit the field of medical microbiology to understand the roles played by the gut microbiota in resisting the colonization of gut pathogens. …”
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Mitochondrial dysfunction in Down Syndrome: from pathology to therapy by Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa

“…Mitochondria play a crucial role in various vital functions in eukaryotic cells, especially in energy production, calcium homeostasis and programmed cell death. …”
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2023 roadmap for materials for quantum technologies by Becher, Christoph, Gao, Weibo, Kar, Swastik, Marciniak, Christian D., Monz, Thomas, Bartholomew, John G., Goldner, Philippe, Loh, Huanqian, Marcellina, Elizabeth, Goh, Johnson Kuan Eng, Koh, Teck Seng, Weber, Bent, Mu, Zhao, Tsai, Jeng-Yuan, Yan, Qimin, Huber-Loyola, Tobias, Höfling, Sven, Gyger, Samuel, Steinhauer, Stephan, Zwiller, Val

“…These include both the inherent quantum bit systems and materials playing supportive or enabling roles, and cover trapped ions, neutral atom arrays, rare earth ion systems, donors in silicon, color centers and defects in wide-band gap materials, two-dimensional materials and superconducting materials for single-photon detectors. …”
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Identification and functional analysis of Git3 G protein-coupled receptors in Ganoderma boninense PER71 by Khairunnisa Hanisah Mohd Daud, Mohd Faizal Abu Bakar, Izwan Bharudin, Shazilah Kamaruddin, Huai, Doris Xia Quay, Farah Diba Abu Bakar, Abdul Munir Abdul Murad

“…G protein-coupled receptors (GPCRs) are integral components of eukaryotic heterotrimeric G proteins, playing crucial roles in detecting extracellular signals and initiating the activity of signaling proteins within cells to activate cellular responses to these signals. …”
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Chromosome-level genome assembly of the diploid blueberry Vaccinium darrowii provides insights into its subtropical adaptation and cuticle synthesis by Cui, Fuqiang, Ye, Xiaoxue, Li, Xiaoxiao, Yang, Yifan, Hu, Zhubing, Overmyer, Kirk, Brosché, Mikael, Yu, Hong, Salojärvi, Jarkko

“…This conserved genome structure may explain the high fertility observed during crossbreeding of V. darrowii with other blueberry cultivars. Analysis of gene expansion and tandem duplication indicated possible roles for defense- and flowering-associated genes in the adaptation of V. darrowii to the subtropics. …”
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Temperature induced biological alterations in the major carp, Rohu (Labeo rohita): assessing potential effects of climate change on aquaculture production by Mridul, Md. Monirul Islam, Zeehad, Md. Shariar Kabir, Aziz, Dania, Salin, Krishna R., Hurwood, David A., Rahi, Md. Lifat

“…Temperature plays a profound role in organismal growth, immunity, survival, and the entire biological systems of any aquatic species. …”
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Characterizing Cortex-Hippocampus Interactions During Language Processing by Lee, Jiachen Elizabeth

“…The role of medial temporal lobe structures, including that of the hippocampus, in language processing, remain largely unknown. …”
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Molecular cloning, expression, purification and crystallization of BcsG for structural analysis in escherichia coli by Lee, Jin

“…Genes such as BcsG have been found to play a crucial role in cellulose synthase formation as well and yet, little is known about BcsG apart from functional studies and theorized interaction with other Bcs proteins. …”
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Port service quality in the supply chain management context by Poh, Patricia Xiang Qi.

“…However, there has been a general shift in the roles of the port. Besides the traditional function of being the facilitator, providing of infrastructure and equipment, contemporary ports have now been integrated into supply chains. …”
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Effects of HSV-G47∆ oncolytic virus on telomerase and telomere length alterations in glioblastoma multiforme cancer stem cells under hypoxia and normoxia conditions by Vazifehmand, Reza, Saeed Ali, Dhuha, Monem Homaie, Foroozandeh, Molaei Jalalvand, Fatemeh, Othman, Zulkefley, Deming, Chau, Stanslas, Johnson, Sekawi, Zamberi

“…Telomerase activity and telomere length alterations have been known to play a critical role in glioblastoma progression and invasion. Objective: This study aimed to investigate the effects of HSV-G47∆ oncolytic virus on telomerase and telomere length alterations in U251GBMCSCs (U251-Glioblastoma cancer stem cells) under hypoxia and normoxia conditions. …”

Effect of vitamin A on adult lung function: a triangulation of evidence approach by Mongey, R, van der Plaat, DA, Shaheen, SO, Portas, L, Potts, J, Hind, MD, Minelli, C

“…Background: Vitamin A, an essential micronutrient obtained through the diet, plays a crucial role in lung development and contributes to lung regeneration. …”

Novel loci and biomedical consequences of iron homoeostasis variation by Allara, E, Bell, S, Smith, R, Keene, SJ, Gill, D, Gaziano, L, Morselli Gysi, D, Wang, F, Tragante, V, Mason, A, Karthikeyan, S, Lumbers, RT, Bonglack, E, Ouwehand, W, Roberts, DJ, Dowsett, J, Ostrowski, SR, Larsen, MH, Ullum, H, Pedersen, OB, Brunak, S, Banasik, K, Erikstrup, C, Mitchell, J

“…Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. …”

Origins and immunopathogenesis of autoimmune central nervous system disorders by Ramanathan, S, Brilot, F, Irani, SR, Dale, RC

“…Fourth, we outline how advances in our understanding of the anatomy of lymphatic drainage and neuroimmune interfaces are challenging long-held notions of CNS immune privilege, with direct relevance to CNS autoimmunity, and how disruption of B cell and T cell tolerance and the passage of immune cells between the peripheral and intrathecal compartments have key roles in initiating disease activity. Last, we consider novel therapeutic approaches based on our knowledge of the immunopathogenesis of autoimmune CNS disorders.…”

Global response of Vibrio cholerae to predation by heterotrophic protists by Hu, Jie

“…Vibrio cholerae, a Gram-negative bacterium that causes cholera, has played a significant role in the path of human history. Previous studies show protozoan predation is the main biological factor constraining bacterial growth in the environment. …”
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A novel eukaryotic RdRP-dependent small RNA pathway represses antiviral immunity by controlling an ERK pathway component in the black-legged tick by Feng, Canran, Torimaru, Kyosuke, Lim, Mandy Yu Theng, Chak, Li-Ling, Shiimori, Masami, Tsuji, Kosuke, Tanaka, Tetsuya, Iida, Junko, Okamura, Katsutomo

“…Small regulatory RNAs (sRNAs) are involved in antiviral defense and gene regulation. Although roles of RNA-dependent RNA Polymerases (RdRPs) in sRNA biology are extensively studied in nematodes, plants and fungi, understanding of RdRP homologs in other animals is still lacking. …”
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Functional metagenomic analysis of quorum sensing signaling in a nitrifying community by Tan, Chuan Hao, Yeo, Yee Phan, Muhammad Hafiz Ismail, Ng, Noele Kai Jing, Subramoni, Sujatha, Taj, Shireen, Tay, Martin, Chao, Xie, Kjelleberg, Staffan, Rice, Scott A.

“…In wastewater treatment systems, acylated homoserine lactone (AHL)-based QS has been correlated with the conversion of floccular biomass into microbial granules, as well as EPS production and the nitrogen removal process. However, the role of QS in such complex communities is still not fully understood, including the QS-proficient taxa and the functional QS genes involved. …”
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