Mapping miRNA research in schizophrenia: a scientometric review by Lim, Mengyu, Carollo, Alessandro, Neoh, Michelle Jin Yee, Esposito, Gianluca

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Molecular dynamics simulation of RNA ribosomal frameshift stimulatory elements by Seah, Yi Ling

“…The RNA hairpin-type pseudoknots and stem-loops structures are essential downstream elements for minus-one ribosomal frameshifting. …”
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Structural basis of RNA binding by leucine zipper GCN4 by Nikolaev, Yaroslav, Pervushin, Konstantin

“…Solution NMR experiments showed that the LZ-RNA interaction interface is located in the first two heptads of LZ moiety, and that only the dimeric (coiled coil) LZ conformation is capable of binding RNA. …”
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An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion by Collins, Katherine M., Kainov, Yaroslav A., Christodolou, Evangelos, Ray, Debashish, Morris, Quaid, Hughes, Timothy, Taylor, Ian A., Makeyev, Eugene V., Ramos, Andres

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Quantum dots-siRNA nanoplexes for gene silencing in central nervous system tumor cells by Lin, Guimiao, Chen, Ting, Zou, Jinyun, Wang, Yucheng, Wang, Xiaomei, Li, Jiefeng, Huang, Qijun, Fu, Zicai, Zhao, Yingying, Lin, Marie Chia-Mi, Xu, Gaixia, Yong, Ken-Tye

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Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing by Li, Bowen, Manan, Rajith Singh, Liang, Shun-Qing, Gordon, Akiva, Jiang, Allen, Varley, Andrew, Gao, Guangping, Langer, Robert, Xue, Wen, Anderson, Daniel

“…Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for messenger RNA and CRISPR-Cas9 gene editors. Lead lipid nanoparticles are amenable for repeated intratracheal dosing and could achieve efficient gene editing in lung epithelium, providing avenues for gene therapy of congenital lung diseases.…”
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Weighted-persistent-homology-based machine learning for RNA flexibility analysis by Pun, Chi Seng, Yong, Brandon Yung Sin, Xia, Kelin

“…Our WPHML model is validated on a well-established RNA dataset, and numerical experiments show that our model can achieve a PCC of up to 0.5822. …”
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RNA thermosensors facilitate Streptococcus pneumoniae and Haemophilus influenzae immune evasion by Eichner, Hannes, Karlsson, Jens, Spelmink, Laura, Pathak, Anuj, Sham, Lok-To, Henriques-Normark, Birgitta, Loh, Edmund

“…We identify and characterise four novel RNA thermosensors in S. pneumoniae and H. influenzae, responsible for capsular biosynthesis and production of factor H binding proteins. …”
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Identification of RNA-Tis11b complexes in activated B cells. by Tang, Ngang Heok.

“…RNA-binding proteins (RBPs) play important roles in regulating gene expression at post-transcriptional level. …”
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Optimization of SMART-based PCR for amplification from picogram amounts of RNA. by Lin, Zhaoting.

“…To overcome the problem, a SMART-based PCR technique is optimized to accurately amplify subnanograms of total RNA to yield dsCDNA for microarray hybridization and subsequent analyses. …”
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Identification of microRNA targets for the alternative splicing isoforms of CD46. by Teo, Zhi Lin.

“…One class of regulatory molecules that can regulate gene expression is the miRNAs. Currently, only miRNA-520 (miR-520) has been found to target the 3’UTR of CD46. …”
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The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis by Ng, Shi-Yan, Bogu, Gireesh K., Soh, Boon Seng, Stanton, Lawrence Walter

“…RMST and SOX2 coregulate a large pool of downstream genes implicated in neurogenesis. Through RNA interference and genome-wide SOX2 binding studies, we found that RMST is required for the binding of SOX2 to promoter regions of neurogenic transcription factors. …”
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Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…This is partly due to the technically challenging aspect of capturing live mRNA dynamics and partly because only a few examples have been studied in detail. …”

Oral mRNA delivery using capsule-mediated gastrointestinal tissue injections by Abramson, Alex, Kirtane, Ameya R., Shi, Yunhua, Zhong, Grace, Collins, Joy E., Tamang, Siddartha, Ishida, Keiko, Hayward, Alison, Wainer, Jacob, Rajesh, Netra Unni, Lu, Xiaoya, Gao, Yuan, Karandikar, Paramesh, Tang, Chaoyang, Lopes, Aaron, Wahane, Aniket, Reker, Daniel, Frederiksen, Morten Revsgaard, Jensen, Brian, Langer, Robert, Traverso, Giovanni

“…We anticipate oral delivery of mRNA could facilitate rapid deployment of episodic interventions, such as vaccines, and support long-term therapies.…”
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Interpretable Computational Modeling of pre-mRNA Splicing for Multiple Eukaryotic Species by McCue, Kayla M.

“…One of the key steps in eukaryotic gene expression is pre-mRNA splicing, whereby intronic sequences are excised from immature pre-mRNA transcripts and the remaining exonic sequences are joined together. …”
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Tracing RNA biography: in situ transcriptome profiling by novel spatial omics technologies by Ren, Jingyi (Rena)

“…Presently, the state-of-the-art spatial transcriptomic techniques offer only static snapshots of RNA expression, falling short of capturing RNA dynamics and their controlled translation within subcellular domains. …”
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Site-specific chemical and topological modifications to augment mRNA therapeutic potential by Aditham, Abhishek J.

“…Synthetic mRNA has emerged as a promising therapeutic platform for the treatment of a wide variety of diseases. …”
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Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation by Ando, Daisuke, Rashad, Sherif, Begley, Thomas J., Endo, Hidenori, Aoki, Masashi, Dedon, Peter C., Niizuma, Kuniyasu

“…The tRNA epitranscriptome has been recognized as an important player in mRNA translation regulation. …”
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Development of an inducible single lentiviral vector-based microRNA knockdown construct. by Ip, Jun Yu.

“…Perturbations in the levels of individual miRNAs or classes of miRNAs are associated with the pathogenesis of a wide range of human diseases. RNA interference (RNAi) is an efficient approach for rapid analysis of gene functions. …”
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Non-invasive nanosensor monitoring of mRNA expression for regenerative medicine application by Wiraja, Christian

“…Conventionally, such verification is achieved through end-point, population-based methods like polymerase chain reaction (PCR; for mRNA expression) or western blotting (for protein expression). …”
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