TIRR regulates mRNA export and association with P bodies in response to DNA damage by Glossop, M, Chelysheva, I, Ketley, R, Alagia, A, Gullerova, M

“…Furthermore, TIRR plays a crucial role in modulation of RNA processing bodies (P bodies/PBs). TIRR itself and TIRR-bound RNA co-localises with PBs, and TIRR depletion results in nuclear RNA retention and impaired PB formation. …”

Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation by Nakagawa, R, Llorian, M, Varsani-Brown, S, Chakravarty, P, Camarillo, JM, Barry, D, George, R, Blackledge, NP, Duddy, G, Kelleher, NL, Klose, RJ, Turner, M, Calado, DP

“…Here, we show that microRNA (miR)−155 mediates metabolic reprogramming during positive selection to protect high-affinity clones. …”

Overcoming barriers to single-cell RNA sequencing adoption in low- and middle-income countries by Boakye Serebour, T, Cribbs, AP, Baldwin, MJ, Masimirembwa, C, Chikwambi, Z, Kerasidou, A, Snelling, SJB

Enterovirus-like particles encapsidate RNA and exhibit decreased stability due to lack of maturation by Kuijpers, L, Giannopoulou, E, Feng, Y, van den Braak, W, Freydoonian, A, Ramlal, R, Meiring, H, Solano, B, Roos, WH, Jakobi, AJ, van der Pol, LA, Dekker, NH

“…Interestingly, this indicates that CVA6 VLP stability is more affected by lack of viral maturation than the presence of RNA. Our study highlights how the development of VLPs as vaccine candidates should encompass probing for unwanted (viral) RNA content and establishing control of their maturation to enhance stability.…”

Loss of Caᵥ1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory by Zhai, Jing, Navakkode, Sheeja, Yeow, Sean Qing Zhang, Krishna-K, Kumar, Liang, Mui Cheng, Koh, Joanne Huifen, Wong, Rui Xiong, Yu, Wei Ping, Sajikumar, Sreedharan, Huang, Hua, Soong, Tuck Wah

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Malaria parasite stress tolerance is regulated by DNMT2-mediated tRNA cytosine methylation by Hammam, Elie, Sinha, Ameya, Baumgarten, Sebastian, Nardella, Flore, Liang, Jiaqi, Miled, Samia, Bonhomme, Frédéric, Erdmann, Diane, Arcangioli, Benoit, Arimondo, Paola B., Dedon, Peter, Preiser, Peter, Scherf, Artur

“…Using conditional knockout (KO) of a member of the DNA methyltransferase family, called Pf-DNMT2, RNA bisulfite sequencing demonstrated the selective cytosine methylation of this enzyme of tRNAAsp (GTC) at position C38. …”
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The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity by Lu, Xinyi, Sachs, Friedrich, Ramsay, LeeAnn, Jacques, Pierre-Étienne, Göke, Jonathan, Bourque, Guillaume, Ng, Huck-Hui

“…Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. …”
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DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts by Kuś, K, Carrique, L, Kecman, T, Fournier, M, Hassanein, SS, Aydin, E, Kilchert, C, Grimes, JM, Vasiljeva, L

“…Precursor messenger RNA (pre-mRNA) is processed into its functional form during RNA polymerase II (Pol II) transcription. …”

Macrobrachium rosenbergii De Man nodavirus recombinant capsid protein production and its interactions with RNA by Goh, Zee Hong

“…Mutants with the positively-charged amino acids deleted, namely 29ΔMrNvc and 20-29ΔMrNvc did not contain RNA molecules in their VLPs. A point mutation mutant,namely K20R21R22K23R24A, showed a significantly lower amount of RNA molecules compared with that of mutant R26R27R29A, suggesting that the five positively-charged amino acids residues at positions 20 to 24 play an important role in RNA binding. …”
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Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1 by Stubna, Michael William

“…Some rapidly degraded miRNAs owe their instability to a mechanism termed target-directed miRNA degradation (TDMD), whereby unusual miRNA binding sites with extensive complementarity to the miRNA promote a conformational shift in AGO, leading to the recruitment of an E3 ubiquitin ligase complex containing the substrate receptor ZSWIM8. …”
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Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors by Luo, Dahai

“…The RIG-I-like receptors (RLRs)—RIG-I, MDA5, and LGP2—detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. …”
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Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1 by Zhang, Kuo, Law, Yee-Song, Law, Michelle Cheok Yien, Tan, Yaw Bia, Wirawan, Melissa, Luo, Dahai

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Nontoxic, biodegradable hyperbranched poly(β-amino ester)s for efficient siRNA delivery and gene silencing by Ooi, Ying Jie, Huang, Chongquan, Lau, Kieran, Chew, Sing Yian, Park, Jong Gu, Chan-Park, Mary B.

“…To overcome these barriers, we designed and optimized a series of hyperbranched pBAEs capable of efficiently condensing siRNA and achieving excellent silencing efficiency at a lower polymer/siRNA weight ratio (w/w) and siRNA dose. …”
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Biofunctional electrospun nanofibrous scaffolds in tissue engineering and the potential application of siRNA-delivery for nerve regeneration by Cao, Haoqing

“…A scaffold-based drug delivery system was developed by incorporating small interfering RNA (siRNA) into PCL nanofibers for long-term RNA interference (RNAi) therapy. …”
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Recognition of A-U and U-A base pairs in RNA duplexes by modified peptide nucleic acids by Yuan, Zhen

“…RNA triplex structures play vital roles in regulating various biological processes, and have attracted a Jot of interest in designing TFOs (triplex-fonning oligomers) that could selectively and specifically bind to the nuclei acid duplex. …”
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Live-cell imaging and functional dissection of Xist RNA reveal mechanisms of X chromosome inactivation and reactivation by Ha, Norbert How Ong, Lai, Lan-Tian, Chelliah, Rosi, Zhen, Yashu, Seet, Vanessa Pei Yi, Lai, Soak-Kuan, Li, Hoi-Yeung, Ludwig, Alexander, Sandin, Sara, Chen, Lingyi, Zhang, Li-Feng

“…We double-tagged Xist (inactivated X chromosome-specific transcript), a prototype long non-coding RNA pivotal for X chromosome inactivation (XCI), using the programmable RNA sequence binding domain of Pumilio protein, one tag for live-cell imaging and the other replacing A-repeat (a critical domain of Xist) to generate “ΔA mutant” and to tether effector proteins for dissecting Xist functionality. …”
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Ultrasensitive cDNA detection of dengue virus RNA using electrochemical nanoporous membrane-based biosensor by Rai, Varun, Hapuarachchi, Hapuarachchige C., Ng, Lee Ching, Soh, Siew Hwa, Leo, Yee Sin, Toh, Chee-Seng

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Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development by Eslamkhah, Sajjad, Aslan, Elif Sibel, Yavas, Cuneyd, Akcali, Nermin, Batur, Lutfiye Karcioglu, Abuaisha, Asmaa, Yildirim, Erva Esma, Solak, Mustafa, White, Kenneth

“…This review explores the epidemiology, pathophysiology, and clinical manifestations of MPXV, along with current treatment strategies and the role of mRNA vaccines. It emphasizes the importance of understanding the changing dynamics of Mpox transmission, which are influenced by factors such as waning immunity from smallpox vaccinations and increased global interconnectedness. …”
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In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy by Guimarães, Pedro PG, Figueroa-Espada, Christian G, Riley, Rachel S, Gong, Ningqiang, Xue, Lulu, Sewastianik, Tomasz, Dennis, Peter S, Loebel, Claudia, Chung, Amanda, Shepherd, Sarah J, Haley, Rebecca M, Hamilton, Alex G, El-Mayta, Rakan, Wang, Karin, Langer, Robert, Anderson, Daniel G, Carrasco, Ruben D, Mitchell, Michael J

“…We used combinatorial chemistry and high-throughput in vivo screening methods to engineer a nanoparticle platform for small interfering RNA (siRNA) delivery to bone marrow endothelium. …”
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Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice by Hamid, Fursham M., Makeyev, Eugene V.

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