Determining targets for antiretroviral drug concentrations: a causal framework illustrated with pediatric efavirenz data from the CHAPAS-3 trial by Schomaker, M, Denti, P, Bienczak, A, Burger, D, Díaz, I, Gibb, DM, Walker, AS, McIlleron, H

“…<p><strong>Background:&nbsp;</strong>Determining a therapeutic window for maintaining antiretroviral drug concentrations within an appropriate range is required for identifying effective dosing regimens. The limits of this window are typically calculated using predictive models. …”

Estimating evolutionary and demographic parameters via ARG-derived IBD by Huang, Z, Kelleher, J, Chan, Y, Balding, D

“…Inference of evolutionary and demographic parameters from a sample of genome sequences often proceeds by first inferring identical-by-descent (IBD) genome segments. By exploiting efficient data encoding based on the ancestral recombination graph (ARG), we obtain three major advantages over current approaches: (i) no need to impose a length threshold on IBD segments, (ii) IBD can be defined without the hard-to-verify requirement of no recombination, and (iii) computation time can be reduced with little loss of statistical efficiency using only the IBD segments from a set of sequence pairs that scales linearly with sample size. …”

Maximizing the performance of badminton athletes through core strength training: Unlocking their full potential using machine learning (ML) modeling by Ma, Shuzhen, Geok Soh, Kim, Japar, Salimah, Xu, Simao, Zhicheng, Guo

“…Incorporating core strength training into regular regimens can improve athletes' overall strength, endurance, balance, control, and prevent injuries. …”
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Variational mesh decomposition by Zhang, Juyong, Zheng, Jianmin, Wu, Chunlin, Cai, Jianfei

“…The problem of decomposing a 3D mesh into meaningful segments (or parts) is of great practical importance in computer graphics. …”
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Spatio temporal traffic pediction for a large-scale road network by Krishnamoorthy, Nardana

“…The road segments belonging to one of these clusters were then tested. …”
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Thermoplastic polymer nanocomposites based on polydopamine-coated clay : preparation, structures and properties by Phua, Si Lei

“…This strong interfacial interaction between D-clay and hard segments not only facilitates the stress transfer across the filler and polymer matrix, but also acts as nucleating agent for hard segment crystallization, leading to higher hard segment crystallinity. …”
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Treatment options to support the elimination of Hepatitis C: an open label, factorial randomised controlled trial by Cooke, G, Le Manh, H, Flower, B, McCabe, L, Vu Thu Kim, H, Vo Thi, T, Dang Trong, T, Nguyen Thanh, D, Le Thanh, P, Dao Bach, K, Nguyen Thi Chau, A, Pham Ngoc, T, Vu Thu Thu, H, Dang Thi, B, Nguyen Kim, T, Ansari, A, Le Ngoc, C, Vo Minh, Q, Nguyen Thi Ngoc, P, Le Thi, T, Nguyen Bao, T, Kestelyn, E, Kingsley, C, Van Doorn, R, Rahman, M, Pett, S, Thwaites, G, Barnes, E, Day, J, Nguyen Van Vinh, C, Walker, AS

“…No randomised trials have compared these regimens and high cure rates may be achievable with shorter durations of therapy.…”

Reduction of dimensionality of a cellular actuator array for driving a robotic hand by Cho, Kyu-Jin, Ph. D. Massachusetts Institute of Technology

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EU competition law : a roadmap for ASEAN? by Valockova, Barbora

“…The European Union’s competition policy and legal regime is instrumental in the functioning of the single market in the EU. …”
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Characterization of artemisinin resistance in plasmodium falciparum by Rocamora, Frances Maureen C.

“…In order to better understand the Artemisinin resistance phenotype, we developed Artemisinin-resistant parasite lines derived from two isogenic clones (6A and 11C) of the 3D7 strain of Plasmodium falciparum using a selection regimen that mimics how parasites interact with the drug in infected patients. …”
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Drug interaction between acetyltanshinone IIA and rapamycin in breast cancer cells by Wong, De Pin

“…Developing in vitro drug combination study is essential for the development of new and effective combination regimens. In this project, the objective is to investigate the synergistic potential between two anti breast cancer agent, rapamycin and acetyltanshinone IIA (ATA) in breast cancer cells. …”
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Slip along the San Andreas fault associated with the great 1857 earthquake by Sieh, Kerry

“…It is relatively uniform along each of several long segments, but changes rather abruptly in value between these segments. …”
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Using Sequenom to identify KRAS mutations in an Asian cohort of ovarian mucinous cancer by Tiong, Wen Ning

“…While there are distinct differences between mucinous epithelial ovarian cancer (mEOC) and the other subtypes of EOC, a standard treatment regimen is followed for all EOC histotypes. KRAS mutations have been observed to occur in relatively high frequencies of 50-60% in mEOC but not in other subtypes of EOC in at least three clinical studies. …”
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Development of a powermeter for a bicycle – I by Pillarisetty Venkata Pranav

“…More than just being a mode of transportation, bicycling has caught on as a competitive sport in many parts of the world and as an exercise regimen by a sizeable fraction of the global population. …”
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First-line chemotherapy for advanced ovarian cancer: paclitaxel, cisplatin and the evidence by Sandercock, J, Parmar, MKB, Torri, V

“…Two of the reported trials (GOG-111 and the Intergroup trial) provide clear evidence that cisplatin combined with paclitaxel is a more effective regimen than one using the same dose of cisplatin combined with cyclophosphamide. …”

Audio watermarking by Ho, Shuet Mun, Ng, Ling Mei

“…This non-blind watermarking algorithm is based on both time and frequency base modulation. Segments of the file are compressed or expanded by adding or removing samples in the frequency domain. …”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Abstract Background Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. However, HSCT regimens currently commonly utilize genotoxic chemotherapy and/or total body irradiation (TBI) conditioning which causes significant morbidity and mortality through inducing broad tissue damage triggering infections, graft vs. host disease, infertility, and secondary cancers. …”
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Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management by Viana Cabral, Fernanda, Quilez Alburquerque, Jose, Roberts, Harrison James, Hasan, Tayyaba

“…Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. …”
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An interactive control architecture for interpersonal coordination in mirror game by Zhai, Chao, Chen, Michael Z. Q., Alderisio, Francesco, Yu. Uteshev, Alexei, Di Bernardo, Mario

“…In this work, an interactive control architecture based on velocity segments is developed to generate the human-like trajectories in the mirror game, a simple yet effective paradigm for studying interpersonal coordination, and the existence of velocity segments possessing a prescribed signature is theoretically guaranteed. …”
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Self-similar sketch by Vedaldi, A, Zisserman, A

“…The resulting collection of segments constitutes a "sketch" of the image. This is applied to the task of estimating vanishing points, horizon, and zenith in standard benchmark data, obtaining state-of-the-art results. …”