A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53 by Wong, Jin Huei, Alfatah, Mohammad, Sin, Mei Fang, Sim, Hong May, Verma, Chandra Shekhar, Lane, David P., Arumugam, Prakash

“…In addition, we identified a conserved segment in the core DNA-binding domain of p53 that facilitates stable interaction with Mdm2 in yeast cells and in vitro. …”
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Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases by He, Y

“…In addition, mutagenesis and structural studies unveiled an allosteric site, termed the 'DEK' (encompassing the key structural elements DFG motif, Glu315 on the αC helix, and kinase inhibitory segment), crucial in modulating kinase activity.</p> <p>To gain a deeper understanding of the action mechanism underlying PAK1 small molecule activators, fluorescence resonance energy transfer (FRET), superresolution single molecular imaging, and mass photometry were applied to illustrate the conformational changes and alterations in PAK1 dimerization upon the binding of small molecule activators. …”

Robust deep learning methods for accountable contrast-agent-free CMR imaging in clinical applications by Gonzales, RA

“…This approach reduced inter-observer variability and improved the consistency of myocardial segmentation.</p> <br> <p>The fourth goal is to assist the automated segmentation of CMR short-axis slices into the American Heart Association 16-segment model for clinical applications across various CMR modalities. …”

Localization and motion planning of mobile robots by Dai, Yunxiang

“…Afterward, a novel reference path segment generation and switching mechanism are proposed to bridge the perception with the low-level controller. …”
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Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…The MtRel NTD in the presence of TGS domain showed almost similar synthetic activity as of MtRel NTD and approximately 3 fold higher than that of MtRel showing auto-inhibition by rest of the C-terminus MtRel segment. The MtRel ACT structure was determined as a dimer and the oligomeric state was further confirmed using SAXS. …”
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Associations between health literacy and health care utilization and mortality in patients with coexisting diabetes and end-stage renal disease : a prospective cohort study by Griva, Konstantina, Loong, Russel K. L., Nandakumar, Mooppil, Rajeswari, Moothathamby, Khoo, Eric Y. H., Lee, Vanessa Y. W., Kang, Augustine W. C., Osborne, Richard H., Brini, Stefano, Newman, Stanton P.

“…Patients with diabetes (DM) comprise the fastest growing segment of patients with end-stage renal disease (ESRD). …”
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Mechanically durable and damage resilient dielectric elastomer actuators by Tan, Matthew Wei Ming

“…By tuning hard-to-soft segment ratios and molecular weights of polydiols, carboxyl polyurethanes (PULM0) attained large mechanical toughness (96.5 MJ m-3) and puncture resistance. …”
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Tracking and detecting objects in image sequence by Wang, Li

“…Then, a so-called “split-merge” approach is proposed to over-segment a foreground region into subregions and then cluster them into a number of object regions by using the proposed boundary based similarity metric. …”
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Pnictogen-halide semiconductors for photovoltaics by Liu, P

“…Convolutional Neural Network (CNN) models were used to evaluate the density of pinholes in the scanning electron microscopy images, and the Segment Anything Model (SAM) was used to separate different regions within the images. …”

Smuggling of Migrants in Malaysia: The Case Study of Illegal Immigrants in the Northern Region by Ajis, Mohd Na'eim, Ahmad Zakuan, Ummu Atiyah, Mohd. Zain, Zawiyah, Keling, Mohamad Faisol

“…Relevant authorities like Malaysian Maritime Enforcement Agency, Malaysia Immigration Department and Border Ranger Regiment, are being interviewed. Findings reveal that the activities of migrant smuggling are occurring in the Northern Region of the Peninsular Malaysia. …”
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Role of different dendritic cell subsets in vivo by Abdul Rashid Mohammad Muzaki

“…In a dextran sodium sulphate (DSS) model of colonic inflammation, ablation of CD103+ CD11b- colonic DCs resulted in exacerbated colitis, while ablation of colonic CD103+ CD11b+ DCs resulted in resistance to colitis when subjected to the same DSS regiment. Hence our results highlight the opposing roles of these two distinct colonic DC subsets in controlling DSS-induced colonic inflammation. …”
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Design and development of image processing algorithms for classification of vehicles by Zhang, Chunrui

“…In this thesis a new technique is presented, which is based on motion segmentation and some other segmentation approaches such as split-merge and region growing and color image segmentation.…”
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Behaviour of joints in tunnel linings by Alevey, Niall Mac, Ashraf Mohamed Hefny

“…Precast concrete tunnel segments are used extensively to construct tunnel linings. …”
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Machine learning based retinal vessel detection by Li, Hongru

“…Vessel Detection/segmentation based on computer vision and machine learning provides an efficient and economic benefit tool for retinal image analysis. …”
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Self-learning shape recognition in medical images by Ma, Jingting

“…Embedded into an existing segmentation framework, experimental results show that SSM built with the proposed RKPCA outperforms the state-of-the-art modeling techniques in terms of model quality and segmentation accuracy. …”
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Satellite image fusion for land cover classification by Tsan, Li Ling

“…Through the remote sensing techniques using Synthetic Aperture Radar(SAR), SAR images are pre-processed and later segmented to produce the segmentation maps which gives the land cover classification. …”
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Fracture identification in well logging images: two-stage adaptive network by Zhang, Wei, Li, Zhipeng, Wu, Tong, Yao, Zhenqiu, Qiu, Ao, Li, Yanjun, Shi, Yibing

“…Automatic fracture identification and segmentation in well logging images is increasingly critical but arduous because of extensive exploration for oil and gas. …”
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The Enggano-Dutch word list derived from Helfrich's (1916) “Nadere Bijdrage Tot de Kennis van Het Engganeesch” by Rajeg, GPW

“…This version (0.1.1) now includes the word list in a tab-separated file (.tsv) that has the following features (in the columns): (a) common/standardised transcription, also in segmented format (Columns form_common_transcription and form_common_segments); (b) phonemic transcription in segmented format (Column form_ipa_segments); (c) Indonesian translation of the English gloss using the deeplr R package (Column indonesian). …”

Estimating evolutionary and demographic parameters via ARG-derived IBD by Huang, Z, Kelleher, J, Chan, Y, Balding, D

“…Inference of evolutionary and demographic parameters from a sample of genome sequences often proceeds by first inferring identical-by-descent (IBD) genome segments. By exploiting efficient data encoding based on the ancestral recombination graph (ARG), we obtain three major advantages over current approaches: (i) no need to impose a length threshold on IBD segments, (ii) IBD can be defined without the hard-to-verify requirement of no recombination, and (iii) computation time can be reduced with little loss of statistical efficiency using only the IBD segments from a set of sequence pairs that scales linearly with sample size. …”

Satellite optical and radar image fusion for land cover classification by Zhang, Guobin

“…Following that, different segmentation techniques will be applied to the filtered SAR image, such as Watersheld, Chan-Vese, Superpixel and K-Means segmentation methods. …”
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