Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…The accuracy was further supported by the correlation between WTC-based test results and patients' clinical responses in a separate validation study, where the neoadjuvant treatment regimens of 15 BC patients were mimicked. Collectively, the WTC model allows us to accomplish personalized drug testing within 10 d, even for small-sized tumors, highlighting its potential for individualized BC therapy. …”
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Antiretroviral therapy optimisation without genotype resistance testing : a perspective on treatment history based models by Prosperi, Mattia C. F., Sloot, Peter M. A., van de Vijver, David A. M. C., Rosen-Zvi, Michal, Altmann, André, Zazzi, Maurizio, Schülter, Eugen, Struck, Daniel, Di Giambenedetto, Simona, Kaiser, Rolf, Vandamme, Anne-Mieke, Sönnerborg, Anders

“…Sensitivity analyses, carried out on a data subset that included antiretroviral regimens commonly used in low to middle income countries, confirmed our findings. …”
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An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore by Ang, Li Wei, Ng, Oon Tek, Boudville, Irving Charles, Leo, Yee Sin, Wong, Chen Seong

“…Background: While the use of combination antiretroviral therapy (cART) has conferred significant reduction in morbidity and mortality, there are growing concerns about the metabolic complications of antiretroviral regimens in HIV-infected patients. The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) among people living with HIV (PLHIV) in Singapore. …”
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The use of paleomagnetic analysis to assess nonbrittle deformation within the San Andreas fault zone by Sieh, Kerry, Nagy, Elizabeth A.

“…A recently developed paleomagnetic extraction technique successfully permits sample collection from unconsolidated sediments. Traditional measurement and demagnetization procedures can subsequently be performed, and several studies have already shown that soft-sediment samples yield reliable magnetic polarity information. …”
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Association of nucleoside reverse transcriptase inhibitors with adverse perinatal outcomes in pregnant women living with HIV: systematic review and meta-analysis by Cowdell, I, Beck, K, Hey, M, Portwood, C, Sexton, H, Kumarendran, M, Brandon, Z, Kirtley, S, Hemelaar, J

“…ART containing zidovudine was associated with increased risk of very preterm birth (1.59; 1.01-2.49), small for gestational age (1.33; 1.03-1.70), very small for gestational age (1.63; 1.25-2.13), stillbirth (2.23; 1.10-4.55), and neonatal death (1.65; 1.08-2.52), compared to ART not containing zidovudine. For ART regimens also containing either lamivudine or emtricitabine, zidovudine was associated with increased risk of very preterm birth (1.62; 1.04-2.52), small for gestational age (1.52; 1.28-1.82), very small for gestational age (1.68; 1.36-2.06), stillbirth (2.19; 1.03-4.67), and neonatal death (1.65; 1.08- 2.52), compared to ART containing tenofovir disoproxil fumarate. …”

Geochemical heterogeneity in the Hawaiian plume : constraints from Hawaiian volcanoes and Emperor seamounts by Huang, Shichun

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Multi-colony coral skeletal Ba/Ca from Singapore’s turbid urban reefs : relationship with contemporaneous in-situ seawater parameters by Tanzil, Jani Thuaibah Isa, Goodkin, Nathalie Fairbank, Sin, T. M., Chen, Mengli, Fabbro, Gareth Nicholas, Boyle, E. A., Lee, A. C., Toh, K. B.

“…A negative relationship between Ba/Cacoral and total sedimentation rate was also found, suggesting that within reef sediment fluxes may be influencing spatio-temporal variability of the Ba-supply. …”
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The dietetic practice of prescribing amino acid-based formulas in paediatrics patients without cow’s milk allergy: a single centre retrospective study by O’Connor, Graeme, Mansell, Melissa

“…Data were collected on demographics, anthropometrics, feed regimens, gastrointestinal symptoms, proton pump inhibitor use and serum phosphate concentration Results: 203 children were prescribed an AAF during the data collection period, of these, 154 of 203 (76%) patients had no allergies. …”
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Exploring connections between seagrass ecosystem services and meadow hydrodynamics by Schaefer, Rachel

“…Second, field experiments were performed in three Massachusetts, USA seagrass meadows to relate spatial patterns in hydrodynamics with spatial patterns in sediment organic carbon. Lower velocities were expected to reduce sediment mobility and thus enhance the deposition and retention of sediment carbon. …”
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Mathematical modelling of subglacial drainage and erosion by Ng, FSL

“…In this thesis, we substantiate these developments by exploring a detailed model where the channel is underlain by subglacial till and the flow supports a sediment load. Attention is given to the physics of bed processes and its effect on channel morphology. …”

Novel viral vector vaccines for tropical infections by Rampling, T

“…One trial evaluates a regimen in which immunisation with RTS,S/AS01B and ChAd63/MVA ME-TRAP is chronologically staggered. …”

Injection effects on settling velocity by Le, Duc Anh

“…Settling is a process by which particulates that experience forces fall to the bottom of a liquid and form sediment at the vessel base. The terminal velocity or settling velocity of particle is an important parameter in sediment transport. …”
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Analysis of bedload transport in laminar flows by Cheng, Nian-Sheng

“…As an extreme case to reflect the viscous effect on sediment transport, sediment transport in laminar flows is considered in this paper. …”
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A generalised study of 3D confined jet at a wall by Lim, Raine Jia Ying

“…Scour, the erosion of seabed sediment by currents or flowing water, poses a significant challenge to the stability of port infrastructure. …”
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The Impact of Vegetation Morphology on Turbulence and Bedload Transport by Zhao, Tian

“…By promoting sediment deposition and retention, aquatic vegetation can contribute to river bank stabilization, biodiversity, as well as carbon sequestration. …”
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EN06 computational environmental hydraulics : pre-treatment filter modeling by Krishnan Moorthi, Pavithra

“…The headloss values have been plotted against time to analyze the impact of incorporating a particle size distribution on the time taken to reach the maximum headloss values and the trend of head loss progression in the filter. Sediment deposition profiles have also been generated to evaluate how the sediment deposition in the filter changes with a changing particle size distribution. …”
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Seepage effects on settling velocity by Goh, Alvin Hanchang.

“…This experimental project investigates the possible effect of upward seepage on the terminal or settling velocity of sediment particles as well as its influence on the different zones of sediment particle motion. …”
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Local scour downstream of a weir by Win, Yone Yone

“…The study extends the scope by examining the scour depth using two median sediment sizes of 0.77mm and 4.75mm. The latter large sediment size has not been tested so far. …”
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The Fluid Mechanics of Deep-Sea Mining by Peacock, Thomas, Ouillon, Raphael

“…The evolution and fate of sediment plumes that would be produced by seabed mining activities, which are central to the assessment of the environmental impact, are entirely determined by transport processes. …”
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From private entrepreneurship to state monopoly: contracting Swiss soldiers for Dutch Service under Ancien Régime Fiscal- Military Practices (1693–1829) by Depreter, M

“…This contribution examines Dutch contracting practices to hire Swiss troops during the Ancien Régime, from the first contracts directly negotiated in the Protestant cantons by Petrus Valckenier (1693-1694) during the Nine Years’ War, seizing opportunities arisen from Louis XIV’s revocation of the Edict of Nantes (1685) after a period during which the Dutch seem to have relied on uncertain access to Swiss manpower through French intercession, up to the end of a short-lived revival of Swiss foreign regiments in the newly-instated Kingdom of the Netherlands (1814-1829). …”