Evaluating new malaria vaccine candidates by Noé, A

“…Liver-resident memory CD8+ T cells (TRM) are necessary for protection against rodent malaria by this vaccine regimen. Ultimately, to most faithfully assess immunological responses by these local, specialised, hepatic T cells, periodic liver sampling is necessary. …”

Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis by Wong, Chee Wai, Czarny, Bertrand, Metselaar, Josbert M., Ho, Candice, Ng, Si Rui, Barathi, Amutha Veluchamy, Storm, Gert, Wong, Tina T.

“…The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system may help to overcome these problems. …”
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Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cyc... by Karpicheva, OE, Simonyan, AO, Kuleva, NV, Redwood, CS, Borovikov, YS

“…Despite its reduced affinity for actin in co-sedimentation assay, the Q147P mutant incorporates into the muscle fiber. …”

Numerical modeling of the influence of scour and scour protection on monopile dynamic behavior by Mayall, RO, Burd, HJ, McAdam, RA, Byrne, BW, Whitehouse, RJS, Heald, SG, Slater, PL

“…Scour of seabed sediments can occur around offshore foundations. For monopile-supported offshore wind turbine structures, the reduction in foundation stiffness due to scour presents certain operational challenges. …”

Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…These results provide evidence for 5FU-CaCO3np as a novel regimen against colon cancer. Combining 5FU-CaCO3np and TQ may offer a new perspective for colon cancer therapy.…”
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Behavior of the southernmost San Andreas fault during the past 300 years by Sieh, Kerry, Williams, Patrick L.

“…This behavior may be due to tectonically induced high pore pressures in the coarse sediments that abut the fault.…”
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Protracted carbon burial following the Early Jurassic Toarcian Oceanic Anoxic Event (Posidonia Shale, Lower Saxony Basin, Germany) by Celestino, RFS, Ruhl, M, Dickson, AJ, Idiz, E, Jenkyns, HC, Leng, MJ, Mattioli, E, Minisini, D, Hesselbo, SP

“…The bio- and chemostratigraphic framework presented demonstrates that (i) the rock record of the T-OAE at the studied locality registered highly condensed sedimentation and/or multiple hiatuses and (ii) the deposition of organic-rich black shale extended significantly beyond the level of the T-OAE, thereby contrasting with well-studied sections of the Posidonia Shale in southern Germany but showing similarities with geographically nearby basins such as the Paris Basin (France). …”

Tapered angle microfluidic device for cell separation using hydrodynamic principle by Jamrus, Muhammad Asyraf, Ahmad, Mohd. Ridzuan

“…This design enables particle separation based on hydrodynamic theory and the sedimentation process. A mixture of 3 μm and 10 μm polystyrene (PS) microbeads were effectively separated when the taper angle approached 20 degrees, and separation continued until the taper angle reached 89 degrees. …”

Tapered angle microfluidic device for cell separation using hydrodynamic principle by Jamrus, Muhammad Asyraf, Ahmad, Mohd. Ridzuan

“…Based on the hydrodynamic theory and sedimentation process, this design allows particles to separate. …”
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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…FEDORA uses a within-patient dose escalation regimen to ensure each patient reaches a personalised dose combination that is acceptable. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. …”

Performance augmentation of retrofitted sustainable R1234yf in R134a air conditioning system using AI2O3 SiO2 hybrid nanolubricant by M. Z., Sharif, Wan Azmi, Wan Hamzah, Mohd Fairusham, Ghazali, Hafiz, Muhammad Ali

“…The stability test shows that the hybrid nanolubricant remained in superior stability after 6 months, with minimum particle aggregation and sedimentation. The AAC-Al2O3–SiO2/DEC PAG system achieved the best performance at 0.03% volume concentration with an average increment of 12.01%. …”
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Chemical dispersant enhances microbial exopolymer (EPS) production and formation of marine oil/dispersant snow in surface waters of the subarctic northeast Atlantic by Suja, Laura Duran, Chen, Xindi, Summers, Stephen, Paterson, David M., Gutierrez, Tony

“…A notable feature of the Deepwater Horizon oil spill was the unprecedented formation of marine oil snow (MOS) that was observed in large quantities floating on the sea surface and that subsequently sedimented to the seafloor. Whilst the physical and chemical processes involved in MOS formation remain unclear, some studies have shown that extracellular polymeric substances (EPS) play a role in this process. …”
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Lateral offsets and revised dates of large prehistoric earthquakes at Pallett creek, Southern California by Sieh, Kerry

“…Recent excavation and new radiocarbon dates of sediments at Pallett Creek are the basis for new conclusionsr egarding the late Holocene history of the San Andreas fault. …”
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Dynamic simulation of granular filtration by Leong, Lee Man

“…Simulated values for particle removal due to sedimentation deviated slightly from empirical values. …”
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Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…<em>In-vivo</em> evaluation (Chapter 5) established an optimal dosage regimen (100 mg/kg of NTX in feed) for treating <em>Salmonella</em> infections in poultry without promoting the development of resistance. …”

Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…In each regime, we determine the biological processes that may underpin positive and negative treatment outcomes and assess which treatment (RT, HT or RT + HT) and dosing regimen maximise the reduction in tumour burden. This work enables us to generate a set of hypotheses that may explain some of the widely varying tumour behaviours observed experimentally and clinically.…”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

Enhancement of fexural modulus and strength of epoxy nanocomposites with the inclusion of functionalized GNPs using Tween 80 by Wan Ab Halim, Wan Zateel Aqmaer, Junid, Ramli Junid, Sazali, Norazliane, Siregar, Januar Parlaungan, Abd Razak, Jeeferie, Fitriyana, Deni Fajar, Cionita, Tezara, Jaafar, Jamiluddin

“…Characterization of nanoparticles using SEM shows that ARGNPs indicated a softer image representing a thinner layer of graphene stacks compared to T80GNP which has a tangible solid-looking image resulting from the sedimentation during the process of fltration. Elementally, both ARGNPs and T80GNPs were found to contain carbon, oxygen, and sulfur, as indicated by the EDX spectrum, with the C/O ratio for T80GNPs being 34.7% higher than that for ARGNPs, suggesting the adsorption of Tween 80 molecules on the GNPs after functionalization. …”
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Effect of hysteresis on the stability of residual soil slope by Kristo, Christofer, Rahardjo, Harianto, Satyanaga, Alfrendo

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