Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens by Karavasili, Christina, Babaee, Sahab, Kutty, Shruti, Chu, Jacqueline N., Min, Seokkee, Fitzgerald, Nina, Morimoto, Joshua, Inverardi, Nicoletta, Traverso, Giovanni

“…Simplification of complex medication regimens in polypharmacy positively contributes to treatment adherence and cost‐effective improved health outcomes. …”
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The IDentif.AI-x pandemic readiness platform: rapid prioritization of optimized COVID-19 combination therapy regimens by Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C., Wong, John Eu-Li, Tan, Gladys Gek-Yen, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean

“…A starting pool of 12 candidate drugs developed in collaboration with a community of infectious disease clinicians was first narrowed down to a six-drug pool and then interrogated in 50 combination regimens at three dosing levels per drug, representing 729 possible combinations. …”
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Telacebec (Q203)-containing intermittent oral regimens sterilized mice infected with Mycobacterium ulcerans after only 16 doses by Chauffour, Aurélie, Robert, Jérôme, Veziris, Nicolas, Aubry, Alexandra, Pethe, Kevin, Jarlier, Vincent

“…These results are very promising for future intermittent oral regimens which would greatly simplify BU treatment in the field.…”
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A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border by Ansari, AT, Aung, KK, Win, HH, Beau, C, Nu, B, Soe, NL, Htoo, K, San, T, Wah, TG, Keereevijit, A, Phyo, AP, Chotivanich, K, White, NJ, Nosten, F, Hashmi, AH, Chu, CS

“…Understanding and facilitating adherence to primaquine radical cure regimens is necessary for malaria elimination. Methods: A convergent parallel mixed methods study was conducted to investigate the barriers to and facilitators for completing primaquine treatment of P. vivax infection among mobile migrant communities on the Myanmar-Thailand border. …”

Overall survival by IDH2 mutant allele (R140 or R172) in patients with late-stage mutant- IDH2 relapsed or refractory acute myeloid leukemia treated with enasidenib or conventional care regimens in the phase 3 IDHENTIFY trial by De Botton, S, Risueño, A, Schuh, AC, Lowenberg, B, Kim, H-J, Vyas, P, Wei, AH, Stein, EM, Dohner, H, Fathi, AT, Dinardo, CD, Martin Regueira, P, Taningco, L, Bluemmert, I, Yu, X, See, WL, Hasan, M

The effect of early age feed restriction on subsequent response to high environmental temperatures in female broiler chickens by Zulkifli, I., Che Norma, M.T., Israf, D.A., Omar, A.R.

“…On Day 0, chicks were assigned to one of four feeding regimens; each regimen was applied to four cages of chicks. …”
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Quality of life and compliance with fluid restriction among hemodialysis patients in Hospital Universiti Sains Malaysia by Mohamad, Siti Aniza

“…In conclusion, patients’ knowledge and practice of treatment regimens has to be enhanced and improved so they will be knowledgeable and able to comply to treatment regimens thus increasing their quality of life.…”
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Efficacy of cannabinoids for the prophylaxis of chemotherapy-induced nausea and vomiting—a systematic review and meta-analysis by Chow, R, Basu, A, Kaur, J, Hui, D, Im, J, Prsic, E, Boldt, G, Lock, M, Eng, L, Ng, TL, Zimmermann, C, Scotte, F

“…However, there was no difference between cannabinoid and active treatment alternatives (most using dated single-agent regimens) for any outcomes. A recent phase II/III trial demonstrated superior efficacy of THC:CBD for secondary prevention of CINV when used as adjunctive therapy alongside modern antiemetic regimens, albeit mostly without olanzapine. …”

Advancing the chemotherapy of tuberculous meningitis: a consensus view by Wasserman, S, Donovan, J, Kestelyn, E, Watson, JA, Aarnoutse, RE, Barnacle, JR, Boulware, DR, Chow, FC, Cresswell, FV, Davis, AG, Dooley, KE, Figaji, AA, Gibb, DM, Huynh, J, Imran, D, Marais, S, Meya, DB, Misra, UK, Modi, M, Raberahona, M, Ganiem, AR, Rohlwink, UK, Ruslami, R, Seddon, JA, Skolimowska, KH, Solomons, RS, Stek, CJ, Thuong, NTT, van Crevel, R, Whitaker, C, Thwaites, GE, Wilkinson, RJ

“…Antimicrobial treatment is based on regimens used for pulmonary tuberculosis, which overlooks important differences between lung and brain drug distributions. …”

Determining targets for antiretroviral drug concentrations: a causal framework illustrated with pediatric efavirenz data from the CHAPAS-3 trial by Schomaker, M, Denti, P, Bienczak, A, Burger, D, Díaz, I, Gibb, DM, Walker, AS, McIlleron, H

“…<p><strong>Background:&nbsp;</strong>Determining a therapeutic window for maintaining antiretroviral drug concentrations within an appropriate range is required for identifying effective dosing regimens. The limits of this window are typically calculated using predictive models. …”

Maximizing the performance of badminton athletes through core strength training: Unlocking their full potential using machine learning (ML) modeling by Ma, Shuzhen, Geok Soh, Kim, Japar, Salimah, Xu, Simao, Zhicheng, Guo

“…Incorporating core strength training into regular regimens can improve athletes' overall strength, endurance, balance, control, and prevent injuries. …”
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Treatment options to support the elimination of Hepatitis C: an open label, factorial randomised controlled trial by Cooke, G, Le Manh, H, Flower, B, McCabe, L, Vu Thu Kim, H, Vo Thi, T, Dang Trong, T, Nguyen Thanh, D, Le Thanh, P, Dao Bach, K, Nguyen Thi Chau, A, Pham Ngoc, T, Vu Thu Thu, H, Dang Thi, B, Nguyen Kim, T, Ansari, A, Le Ngoc, C, Vo Minh, Q, Nguyen Thi Ngoc, P, Le Thi, T, Nguyen Bao, T, Kestelyn, E, Kingsley, C, Van Doorn, R, Rahman, M, Pett, S, Thwaites, G, Barnes, E, Day, J, Nguyen Van Vinh, C, Walker, AS

“…No randomised trials have compared these regimens and high cure rates may be achievable with shorter durations of therapy.…”

Drug interaction between acetyltanshinone IIA and rapamycin in breast cancer cells by Wong, De Pin

“…Developing in vitro drug combination study is essential for the development of new and effective combination regimens. In this project, the objective is to investigate the synergistic potential between two anti breast cancer agent, rapamycin and acetyltanshinone IIA (ATA) in breast cancer cells. …”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Further, to augment efficacy, combination regimens were also explored. Results We confirm that only ACK2 inhibits SCF binding fully and prevents HSC proliferation in vitro. …”
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Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management by Viana Cabral, Fernanda, Quilez Alburquerque, Jose, Roberts, Harrison James, Hasan, Tayyaba

“…Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. …”
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Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats by Taha, A.A., Elsheikh, H.A., Khalafalla, A.E., Osman, I. A. M., Abdullah, A. Salam

“…The present study has shown that, despite the significant differences in some of the drug pharmacokinetic parameters between sheep and goats for the i.v. route, identical intravenous and intramuscular dosage regimens of tylosin may be recommended for the two species.…”
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In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles by Shi, Dennis, Toyonaga, Sho, Anderson, Daniel G

“…However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. …”
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Behind every domain there is a shift: adapting distortion-aware vision transformers for panoramic semantic segmentation by Zhang, J, Yang, K, Shi, H, ReiB, S, Peng, K, Ma, C, Fu, H, Torr, PHS, Wang, K, Stiefelhagen, R

“…Extensive experiments are conducted, which cover indoor and outdoor scenarios, and each of them is investigated with Pin2Pan and Syn2Real regimens. Trans4PASS+ achieves state-of-the-art performances on four domain adaptive panoramic semantic segmentation benchmarks. …”

Knowledge and practice regarding medication use among elderly with chronic diseases in Felda Tembangau 2, Kemayan, Pahang by Farid, Aina Natasha Mohd

“…The elderly population, defined as those aged 60 and above, faces unique challenges in managing chronic diseases due to physiological changes, limited access to healthcare information, and barriers in understanding and adhering to medication regimens. The aim of this study was to determine the levels of knowledge and practice regarding medication use among elderly with chronic diseases in FELDA Tembangau 2, Kemayan, Pahang and to explore the correlation between these two variables. …”
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The prevention and management of chronic kidney disease among patients with metabolic syndrome by Zhu, D, Judge, PK, Wanner, C, Haynes, R, Herrington, WG

“…In addition, statin-based regimens lower low-density lipoprotein cholesterol and reduce the risk of atherosclerotic disease (with no clinically meaningful effect on kidney outcomes). …”