Commercialization strategy for FormaCyte therapeutics: Type 1 diabetes patient insights and regulatory pathway analysis on US FDA's impact on other jurisdictions by Liu, Fanzheng

“…With Singapore-based developers, FormaCyte stands to benefit from prioritizing FDA approval while leveraging regional strengths and relevant acceleration programs for smooth and expedited market entry across diverse regulatory landscapes.…”
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Optimisation of smart grid comprising of renewable energy and electric vehicles using HOMER software and threshold decision method by Ho, Chang Fei.

“…However, renewable energy poses several problems in a real-site implementation due to high costs involved in initial construction and the limitations of regional conditions including weather condition and geographical location. …”
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Image classification of unlabeled malaria parasites in red blood cells by Zhang, Zheng

“…Viola-Jones object detection framework was applied to extract image regions with to detect red blood cells from background in the first stage. …”
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Mapping of city growth with socio-economic growth data by Mun, Cassandra Ji Kay

“…Grids with higher Capital Stock proportions relative to the total Capital Stock value are concentrated around the central metropolitan regions. Percentage of Capital Stock of a district in the city (proportion of Capital Stock relative to city’s total Capital Stock value) is generally proportional to its percentage area (proportion of district’s area relative to city’s total area). …”
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Impact of BREXIT on key stakeholders of the maritime industry in UK by Ching, Claudia Loke Wei

“…The role of UK in the global maritime industry is essential and significant, given its prevalence in the establishment of shipping routes that connects Europe to major regions in the world. With the first trace of trade relations surfacing in 1973, UK also doubles as a connecting network for key economies in the world to conduct trade with the EU. …”
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Low temperature heat release and ϕ-sensitivity characteristics of iso-octane/air mixtures by Bajwa, AU, White, SP, Leach, FCP

“…It was also found that dominance of charge cooling effects at rich conditions resulted in negative and zero ϕ−sensitivity regions.…”

Enhancing representation of data-scarce reservoir-regulated river basins using a hybrid DL-process based approach by Deng, L, Zhang, X, Slater, LJE

“…However, human impacts remain challenging to depict in regions where upstream operational information (such as inflow and storage observations) is not available. …”

The English National Lynch Syndrome transformation project: an NHS Genomic Medicine Service Alliance (GMSA) programme by Monahan, KJ, Ryan, N, Monje-Garcia, L, Armstrong, R, Church, DN, Cook, J, Elghobashy, A, Lalloo, F, Lane, S, McDermott, FD, Miles, T, Hardy, SA, Tyson, A, Wang, VYW, Kim, A, Gelinas, S, Faravelli, F, Elmslie, F, Shaw, AC

“…Prior to commencement of the project, there was evidence of variation and low testing levels in eligible patients which is consistent with other health systems; however, we believe this is amenable to systematic improvement with responsibility for testing delivery by local cancer teams supported by regional infrastructure. Methods and analysis: A project team and national oversight group was formed in May 2021 with membership including 21×cancer alliances, 7×GMSAs, charities and other stakeholders who agreed key performance indicators. …”

Strategic and operational issues in sustaining community-based dementia support groups: the Get Real with Meeting Centres realist evaluation part 2 by Morton, T, Evans, SB, Swift, R, Bray, J, Frost, F, Russell, C, Brooker, D, Wong, G, Hullah, N

“…</p> <br> <p><strong>Conclusion:</strong> Collaboration is essential to sustaining community-based initiatives such as MCs, particularly between local community and regional level. MCs need to be vigilant in mitigating pressures that create ‘mission drift’, as targeting a gap in the care pathway and maintaining a person-centred ethos are central to MCs’ appeal. …”

In situ nanoscopy of single-grain nanomorphology and ultrafast carrier dynamics in metal halide perovskites by Zizlsperger, M, Nerreter, S, Yuan, Q, Lohmann, KB, Sandner, F, Schiegl, F, Meineke, C, Gerasimenko, YA, Herz, LM, Siday, T, Huber, MA, Johnston, MB, Huber, R

“…At all of the measured locations, despite topographic irregularities, diffusion is surprisingly homogeneous on the 100&thinsp;nm scale, although it varies between mesoscopic regions. Linking in situ carrier transport with nanoscale morphology and chemical composition could introduce a paradigm shift for the analysis and optimization of next-generation optoelectronics that are based on nanocrystalline materials.…”

Elucidating the non-apoptotic role of the caspases in the Drosophila intestinal system by Arthurton, L

“…Using the Drop-seq single-cell sequencing technique, I observed the misexpression of several regional and cell-specific genes following loss of <em>Dronc</em>. …”

Molecular determinants of chromatin accessibility at CpG islands in mouse embryonic stem cells by King, H

“…This was supported by preliminary work targeting bacterial CpG-rich sequences into the mouse genome, where they were sufficient to establish novel regions of chromatin accessibility. To examine potential mechanisms by which hypomethylated DNA could serve to promote chromatin accessibility, I profiled chromatin accessibility in mouse ESCs lacking various chromatin-modifying proteins which are normally enriched at CGIs, with the histone demethylases KDM2A/B linked to maintaining open chromatin at CGIs. …”

Searching for dark matter in the light of Dark-Higgs Strahlung: a first search for a resonant di-Higgs + missing energy signature with the ATLAS experiment by Brückler, TL

“…These derived limits significantly extend the current best constraints on this model, particularly in the high dark-Higgs and high Z' mass regions.</p> <p>Additionally, this thesis presents a calibration analysis for a boosted double-b tagger, developed to identify two collimated b-jets originating from the decay of a heavy resonance. …”

Prepayment meters strongly associated with multiple types of deprivation and emergency respiratory hospital admissions: an observational, cross-sectional study by Ding, X, Akimova, ET, Zhao, B, Dederichs, K, Mills, MC

“…</p> <p><strong>Methods:</strong> Combining multiple regional data and census estimates at the Lower Layer Super Output Area and the Middle Layer Super Output Area level from England and Wales, we use Spearman&rsquo;s rank correlation, Pearson correlation and multivariate linear regression to empirically establish associations between PPMs and multiple types of deprivation.…”

Cortical neurophysiology of ALS by Proudfoot, M

“…Functional connectivity between cortical regions at rest is appraised in chapter 4. ALS appeared to result in quite striking increases in functional connectivity, in keeping with the fMRI literature and in support of diminished intracortical inhibitory influences. …”

The thermodynamics of multicomponent high-entropy materials by Cantor, B

“…The results show: (1) why large single-phase solid-solution regions are relatively common in multicomponent phase space; (2) why single-phase solid solutions are often favoured over stoichiometric compounds for large numbers of chemically similar components, in concentrated rather than dilute proportions, at high temperatures, and after quenching to room temperature; and (3) the difficulty of detailed thermodynamic analysis in multicomponent materials because of the large numbers of thermodynamic parameters that need to be known and the corresponding lack of underlying thermodynamic measurements.…”

PRMT5 controls the innate immune response by Zhang, C

“…Although additional experiments are required to precisely identify the dsRNA-producing intronic regions, our results support the role of the PRMT5-E2F1 axis in modulating immune responses through the regulation of RNA splicing. …”

Disruption of seasonal influenza circulation and evolution during the 2009 H1N1 and COVID-19 pandemics in Southeastern Asia by Chen, Z, Tsui, JL, Cai, J, Su, S, Viboud, C, du Plessis, L, Lemey, P, Kraemer, MUG, Yu, H

“…During the COVID-19 pandemic, consistent autumn-winter movement waves from Southeastern Asia to temperate regions were interrupted for both subtype/lineages, however the A/H1N1 pandemic only disrupted A/H3N2 spread. …”

‘The plural of silo is not ecosystem’: qualitative study on the role of innovation ecosystems in supporting ‘internet of things’ applications in health and care by Reidy, C, A’Court, C, Jenkins, W, Jani, A, Ramos, A, Morys-Carter, M, Papoutsi, C

“…We sought to examine the multiple interacting influences on IoT implementation, spread and scale-up, including the role of regional innovation ‘ecosystems’ and the impact of the COVID-19 context.…”

Ethical issues surrounding access to care for BRCA mutations by Huang, C

“…I conclude that whilst most problematic cases are country-neutral, only US women are problematically constrained by insurance and legal loopholes, and only UK women are problematically constrained by regional variations in health authority funding.</p>…”