Evaluation of the precision of the Plasmodium knowlesi growth inhibition assay for Plasmodium vivax Duffy-binding protein-based malaria vaccine development by Mertens, JE, Rigby, CA, Bardelli, M, Quinkert, D, Hou, MM, Diouf, A, Silk, SE, Chitnis, CE, Minassian, AM, Moon, RW, Long, CA, Draper, SJ, Miura, K

“…Results of the in vitro growth inhibition assay (GIA) with transgenic P. knowlesi (Pk) parasites expressing the Pv Duffy-binding protein region II (PvDBPII) correlate with in vivo protection in the first PvDBPII controlled human malaria infection (CHMI) trials, making the PkGIA an ideal selection tool once the precision of the assay is defined. …”

The English National Lynch Syndrome transformation project: an NHS Genomic Medicine Service Alliance (GMSA) programme by Monahan, KJ, Ryan, N, Monje-Garcia, L, Armstrong, R, Church, DN, Cook, J, Elghobashy, A, Lalloo, F, Lane, S, McDermott, FD, Miles, T, Hardy, SA, Tyson, A, Wang, VYW, Kim, A, Gelinas, S, Faravelli, F, Elmslie, F, Shaw, AC

“…Prior to commencement of the project, there was evidence of variation and low testing levels in eligible patients which is consistent with other health systems; however, we believe this is amenable to systematic improvement with responsibility for testing delivery by local cancer teams supported by regional infrastructure. Methods and analysis: A project team and national oversight group was formed in May 2021 with membership including 21×cancer alliances, 7×GMSAs, charities and other stakeholders who agreed key performance indicators. …”

Strategic and operational issues in sustaining community-based dementia support groups: the Get Real with Meeting Centres realist evaluation part 2 by Morton, T, Evans, SB, Swift, R, Bray, J, Frost, F, Russell, C, Brooker, D, Wong, G, Hullah, N

“…</p> <br> <p><strong>Conclusion:</strong> Collaboration is essential to sustaining community-based initiatives such as MCs, particularly between local community and regional level. MCs need to be vigilant in mitigating pressures that create ‘mission drift’, as targeting a gap in the care pathway and maintaining a person-centred ethos are central to MCs’ appeal. …”

Elucidating the non-apoptotic role of the caspases in the Drosophila intestinal system by Arthurton, L

“…Using the Drop-seq single-cell sequencing technique, I observed the misexpression of several regional and cell-specific genes following loss of <em>Dronc</em>. …”

Prepayment meters strongly associated with multiple types of deprivation and emergency respiratory hospital admissions: an observational, cross-sectional study by Ding, X, Akimova, ET, Zhao, B, Dederichs, K, Mills, MC

“…</p> <p><strong>Methods:</strong> Combining multiple regional data and census estimates at the Lower Layer Super Output Area and the Middle Layer Super Output Area level from England and Wales, we use Spearman&rsquo;s rank correlation, Pearson correlation and multivariate linear regression to empirically establish associations between PPMs and multiple types of deprivation.…”

A realist evaluation to explain and understand the role of paramedics in primary care by Eaton, G, Wong, G, Tierney, S, Williams, V, Mahtani, KR

“…This comparative study collected data from sixty participants across fifteen sites in the UK, and twelve participants across three sites in a specific region in Canada, where Community Paramedicine is well established. …”

‘The plural of silo is not ecosystem’: qualitative study on the role of innovation ecosystems in supporting ‘internet of things’ applications in health and care by Reidy, C, A’Court, C, Jenkins, W, Jani, A, Ramos, A, Morys-Carter, M, Papoutsi, C

“…We sought to examine the multiple interacting influences on IoT implementation, spread and scale-up, including the role of regional innovation ‘ecosystems’ and the impact of the COVID-19 context.…”

Numerical investigations of detonation reinitiation and failure modes from Mach reflection by Zhang, S, Lai, S, Tang, S, Yang, L, Qi, F, Fang, X

“…Compared with different detonation modes in our simulations, the results show that D(κ) curve from the ZND model gives a good indication of the detonation reinitiation region in the distribution map of velocity and curvature. …”

Mixing and warming characterisation of cryogenic hydrogen jets through proper orthogonal decomposition by Tretola, G, Shen, Li, Leach, F, Vogiatzaki, K

“…The heat flux observed in the outer plume instead is not captured by the low-order temporal fluctuations, which means that thermal diffusion is responsible for the warming in this region.…”

A comparison of lesion mapping analyses based on CT versus MR imaging in stroke by Moore, MJ, Jenkinson, M, Griffanti, L, Huygelier, H, Gillebert, CR, Demeyere, N

“…Following standard lesion-mapping analysis methodology, each voxel or region of interest (ROI) were considered as the underlying “target” within CT and MRI data independently. …”

Ethical issues surrounding access to care for BRCA mutations by Huang, C

“…I conclude that whilst most problematic cases are country-neutral, only US women are problematically constrained by insurance and legal loopholes, and only UK women are problematically constrained by regional variations in health authority funding.</p>…”

A diminished large carnivore guild with contrasting species-habitat associations persists outside national parks in Namibia's central-eastern landscape by Verschueren, S, Hofmann, T, Briers-Louw, WD, Kakove, M, Leirs, H, Bauer, H, Marker, L, Cristescu, B

“…The large proportion (80 %) of suitable habitat identified, i.e. where probability of occupancy exceeded 0.5, is an encouraging outcome for the region's potential to hold value for carnivore persistence and potentially recolonization. …”

Quantifying conformational changes in the TCR:pMHC-I binding interface by McMaster, B, Thorpe, CJ, Rossjohn, J, Deane, CM, Koohy, H

“…Results: In support of some case studies, we demonstrate that all complementarity determining region (CDR) loops move to a certain extent but only CDR3α and CDR3β loops modify their shape when binding pMHC-Is. …”

The potential of eight plasma proteins as biomarkers in redefining leptospirosis diagnosis by Fish-Low, Cheng-Yee, Than, Leslie Thian Lung, Ling, King-Hwa, Sekawi, Zamberi

“…Leptospirosis, a notifiable endemic disease in Malaysia, has higher mortality rates than regional dengue fever. Diverse clinical symptoms and limited diagnostic methods complicate leptospirosis diagnosis. …”

Managing phosphorus : under acid soils environment by Musa, Mohamed Hanafi

“…Malaysia lies within the world’s humid tropical region with high humidity, abundant annual rainfall (2,000-3,000 mm), and very little variation in temperature (averaging 27°C). …”
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Scheduled activity energy-aware distributed cluster- based routing algorithm for wireless sensor networks with non-uniform node distribution by Nokhanji, Nooshin

“…However, since the density of nodes varies in each region due to the non-uniform node deployment, in the dense area the sensed and transmitted data are extremely co-related and redundant. …”
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Enhancing construction site performance through technology and management practices as material waste mitigation in the Malaysian construction industry by Mohammed Abdullah Abkar, Mahdi, Yunus, Riduan, Gamil, Yaser, Albaom, Mohammed Abdo

“…The geographical specificity adds depth to the analysis, offering a comprehensive understanding of regional dynamics. Despite acknowledging limitations in technology and material usage, the study offers recommendations for refining waste mitigation and improving construction site performance. …”
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Information fusion and cooperative control for target search and localization in multi-agent sensor networks by Hu, Jinwen

“…The whole surveillance region is partitioned into cells where each cell is associated with a probability of target existence within the cell, which constitutes a probability map for the whole region. …”
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Thermal effects on particle deposition in microchannels by Yan, Zhibin

“…The reduction of particle deposition rate with Reynolds number is attributed to the increased hydrodynamic lift force which hinders the transport of particles from the bulk solution to the near-wall region. For the pulsatile flow which is generated by a specially designed pulsation generation unit, an oscillatory flow component is superimposed onto the steady flow of the particle suspension. …”
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Investigations into high resolution imaging of the aqueous outflow system and cornea by Hong, Jesmond Xun Jie

“…The imaging probe has resolutions of 10.08 line pairs per mm (~49.61 µm) at the iridocorneal angle region and 5.04 line pairs per mm (~99.21 µm) at the fundus. …”
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