Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr by Zhang, Yingdan, Chew, Alvin Bing Liang, Wang, Jing, Yuan, Mingjun, Yam, Joey Kuok Hoong, Luo, Dahai, Yang, Liang

“…Here, we identify P. aeruginosa's global virulence factor regulator Vfr as one target of auranofin. We report the mechanistic insights into the inhibitory mechanism of auranofin and gold(I) analogues to Vfr through structural, biophysical, and phenotypic inhibition studies. …”
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TCR affinity biases Th cell differentiation by regulating CD25, Eef1e1, and Gbp2 by Kotov, Dmitri I., Mitchell, Jason S., Pengo, Thomas, Ruedl, Christiane, Way, Sing Sing, Langlois, Ryan A., Fife, Brian T., Jenkins, Marc K.

“…Rather, high-affinity T cells sustained IL-2R expression longer and expressed two novel Th cell differentiation regulators, Eef1e1 and Gbp2, to a higher level than low-affinity T cells. …”
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Examining a conceptual model of maternal and paternal warmth, emotion regulation and social competence among preadolescent children in Malaysia by Gan, Su-Wan, Tan, Jo-Pei, Ang, Chin-Siang, Cheah, Charissa S. L., Yaacob, Siti Nor, Abu Talib, Mansor

“…Although parental warmth has been shown to be related to children's social competence, the mediating role of preadolescent children's emotion regulation in this context has been less explored, particularly in Asian cultures. …”
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A latent profile analysis of callous-unemotional traits and emotional behavioural problems in early childhood: associations with self-regulation by Tan, Chloe Yi En, Kyeong, Yena, Phua, Desiree, Eriksson, Johan Gunnar, Chen, Helen Yu, Meaney, Michael, Setoh, Peipei

“…The current study addressed this gap and explored the heterogeneity of profiles by examining their relations to children’s self-regulation, which may inhibit the onset of conduct problems. …”
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Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P by Dong, Rui, Saheki, Yasunori, Swarup, Sharan, Lucast, Louise, Harper, J. Wade, De Camilli, Pietro

“…Here, we report that by regulating PI4P levels on endosomes, VAP affects WASH-dependent actin nucleation on these organelles and the function of the retromer, a protein coat responsible for endosome-to-Golgi traffic. …”
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Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor by Chung, Hwa Hwa, Sze, Siu Kwan, Woo, Amanda Rui En, Sun, Yang, Sim, Kae Hwan, Dong, Xue Ming, Lin, Valerie Chun-Ling

“…Mutational analysis revealed the remarkable importance of Lys-464 in regulating PR activity. Single point mutation K464Q or K464A led to ligand-independent PR gel upshift similar to the ligand-induced gel upshift. …”
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Up-regulation of Mcl-1 and Bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replication by Zhong, Yanxin., Liao, Ying., Fang, Shouguo., Tam, James P., Liu, Ding Xiang.

“…Virus-induced apoptosis and viral mechanisms that regulate this cell death program are key issues in understanding virus-host interactions and viral pathogenesis. …”
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Investigating the use of neurofeedback to promote self-regulation of cortical motor activities as a potential rehabilitation tool post-stroke by Huang, Y

“…Therefore, a potential rehabilitative strategy for post-stroke motor recovery is promoting self-regulation of cortical motor activity to rebalance this abnormal brain activation pattern.…”

Deadbeat control for a single-inductor multiple-input multiple-output dc-dc converter by Wang, Benfei, Zhang, Xinan, Ye, Jian, Gooi, Hoay Beng

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Partial desensitization of MYC2 transcription factor alters the interaction with jasmonate signaling components and affects specialized metabolism by Hou, Xin, Singh, Sanjay Kumar, Werkman, Joshua R., Liu, Yongliang, Yuan, Qinghua, Wu, Xia, Patra, Barunava, Sui, Xueyi, Lyu, Ruiqing, Wang, Bingwu, Liu, Xiaoyu, Li, Yongqing, Ma, Wei, Pattanaik, Sitakanta, Yuan, Ling

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Exploring the moderating role of expressive suppression in the relationship between psychopathy and aggression by Maria, Dayla

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Sampling from the random cluster model on random regular graphs at all temperatures via Glauber dynamics by Galanis, A, Goldberg, L, Smolarova, P

“…Recent work by Helmuth, Jenssen, and Perkins detailed the ordered/disordered transition of the model on random Δ-regular graphs for all sufficiently large q and obtained an efficient sampling algorithm for all temperatures β using cluster expansion methods. …”

Identification of potential common cyclic-di-GMP regulated biomarkers among three gram negative bacteria via transcriptomic and metabolomic profiling by Cai, Zhao

“…In most Gram-negative bacteria, biofilm formation can be regulated by a secondary messenger, bis-(3'-5')-cyclic dimeric guanosine monophos-phate, c-di-GMP. …”
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The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster by Patil, Veena S., Anand, Amit, Chakrabarti, Alisha, Kai, Toshie

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A 0.9-µ A quiescent current output-capacitorless LDO regulator with adaptive power transistors in 65-nm CMOS by Chong, Sau Siong, Chan, Pak Kwong

“…An ultra-low quiescent current output-capacitorless low-dropout (OCL-LDO) regulator with adaptive power transistors technique is presented in this paper. …”
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Enhancing E. coli tolerance towards oxidative stress via engineering its global regulator cAMP Receptor Protein (CRP) by Basak, Souvik, Jiang, Rongrong

“…Here, we aim to improve E. coli performance under oxidative stress via engineering its global regulator cAMP receptor protein (CRP), which can directly or indirectly regulate redox-sensing regulators SoxR and OxyR, and other ~400 genes in E. coli. …”
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Relationships among emotion regulation, depression, anxiety, stress, and physical health-related quality of life in coronary heart disease patients by Ng, Min Geng

“…Coronary heart disease (CHD) is the third leading cause of death in Singapore. Although emotion regulation is a significant determinant of CHD patient’s quality of life, not many studies have assessed the impact of change in emotion regulation on physical functioning over time. …”
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Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology by Ahmed, Syed Moiz, Dröge, Peter

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Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma by Xiong, Sinan, Zhou, Jianbiao, Tan, Tze King, Chung, Tae-Hoon, Tan, Tuan Zea, Toh, Sabrina Hui-Min, Tang, Nicole Xin Ning, Jia, Yunlu, See, Yi Xiang, Fullwood, Melissa Jane, Sanda, Takaomi, Chng, Wee-Joo

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A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling by Deng, H, Zhang, J, Wang, Y, Joshi, D, Pi, X, De Val, S, Schwartz, MA

“…Here we report that high FSS suppresses Smad1/5 by elevating KLF2, which induces the bone morphogenetic protein (BMP) pathway inhibitor, BMP-binding endothelial regulator (BMPER), thereby de-inhibiting Akt. In mice, surgically induced high FSS elevated BMPER expression, inactivated Smad1/5 and induced vessel outward remodeling. …”