Insights on the characteristics and therapeutic potential of mesenchymal stem cell-derived exosomes for mitigation of Alzheimer’s disease’s pathogenicity: a systematic review by Mohammed Yousuf Abdi, Sarah, Mustaffa Al-Bakri, Siti Sarah, Nordin, Norshariza

“…Our review discovered that most MSC exosomes could degrade Aβ plaques, enhance neurogenesis, extenuate neuroinflammatory response through microglial activation, regulate apoptosis and reduce oxidative stress. Delivery of exosomal micro-RNAs was also found to reduce neuroinflammation. …”

Expression of recombinant geobacillus SP a-amylase in pichia pastoris GS 115 by Gandhi, Sivasangkary

“…Previously, production of α-amylase SR74 in Escherichia coli expression system under regulation of T7 lac promoter in pET-32b significantly enhanced the amylase activity to 15.3 U/ml as compared to the native strain. …”
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Anti-ageing properties of edible bird's nest ascertained by in vitro and in vivo studies in animal model by Hou, Zhiping

“…Additionally, EBN produced better transcriptional regulation of hippocampal anti-oxidant genes and an Alzheimer disease isrelated genes, and hepatic insulin signaling genes. …”
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Surface peptide functionalization of zeolitic imidazolate framework-8 for autonomous homing and enhanced delivery of chemotherapeutic agent to lung tumor cells by Nurul Akmarina, Mohd Abdul Kamal, Emilia, Abdulmalek, Sharida, Fakurazi, Cordova, Kyle E., Mohd Basyaruddin, Abdul Rahman

“…To mitigate the toxicity effect resulting from this, there is an urgent need to develop active nano delivery systems capable of regulating optimal doses specifically to cancer cells without harming adjacent normal cells. …”
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The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance interferon-β response by Kim, Susana Soo-Yeon, Sze, Lynette, Lam, Kong-Peng

“…The stress granule protein G3BP1, known to arrest mRNA translation, was identified as a regulator of RIG-I–induced IFN-β production. How G3BP1 functions in RIG-I signaling is not known, however. …”
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The opioid receptor influences circadian rhythms in human keratinocytes through the β-arrestin pathway by Bigliardi, Paul, Junnarkar, Seetanshu, Markale, Chinmay, Lo, Sydney, Bigliardi, Elena, Kalyuzhny, Alex, Ong, Sheena, Dunn, Ray, Wahli, Walter, Bigliardi-Qi, Mei

“…Furthermore, we observed that β-arrestin-1 regulates the transcription of its target genes, including PER2, by facilitating histone-4 acetylation. …”
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Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration by Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

“…Our findings highlight that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic oxidative stress and recruits CK1ϵ and oxidized TDP-43 to facilitate its phosphorylation, as seen in TDP-43 proteinopathies.…”
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Early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement: a subanalysis of the randomised-controlled ACOORH tri... by Kempf, Kerstin, Röhling, Martin, Banzer, Winfried, Braumann, Klaus-Michael, Halle, Martin, Schaller, Nina, McCarthy, H. David, Predel, Hans Georg, Schenkenberger, Isabelle, Tan, Susanne, Toplak, Hermann, Martin, Stephan, Berg, Aloys

“…Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. …”
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Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin by Kehinde, Samuel Abiodun, Fatokun, Tolulope Peter, Olajide, Abosede Temitope, Praveena, Sarva Mangala, Sokan-Adeaga, Adewale Allen, Adekunle, Adegbola Philip, Fouad, Dalia, Papadakis, Marios

“…PE-MPs exposure also disrupted significantly (p < 0.005) antioxidant profile by down-regulating the activities of glutathione-S-transferase, catalase (CAT), superoxide dismutase (SOD) and reducing levels of glutathione (GSH) and ascorbic acid (AA) while concentration of malondialdehyde (MDA) levels were increased relative to control. …”
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A Listeria monocytogenes aptasensor on laser inscribed graphene for food safety monitoring in hydroponic water by Cavallaro, Nicholas, Moreira, Geisianny, Vanegas, Diana, Xiang, Dong, Datta, Shoumen P. A., Gomes, Carmen, McLamore, Eric S.

“…Rapid screening of pathogens is a global need to meet food safety and water quality regulations. This study shows the importance of sensors targeting more than one bacterial surface structure in complex samples relevant to the food-water nexus.…”
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Exceptionally active iridium evolved from a pseudo-cubic perovskite for oxygen evolution in acid by Chen, Yubo, Li, Haiyan, Wang, Jingxian, Du, Yonghua, Xi, Shibo, Sun, Yuanmiao, Sherburne, Matthew, Ager, Joel W., Fisher, Adrian C., Xu, Jason Zhichuan

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High velocity domain wall propagation using voltage controlled magnetic anisotropy by Tan, Fu Nan, Gan, Wei Liang, Ang, Calvin Ching Ian, Liu, H. X., Poh, F., Lew, Wen Siang, Wong, G. D. H.

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Multiple hollow-core anti-resonant fiber as a supermodal fiber interferometer by Huang, Xiaosheng, Zang, Jichao, Yoo, Seongwoo

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Eurotium cristatum fermented okara as a potential food ingredient to combat diabetes by Chan, Li Yan, Takahashi, Masaki, Lim, Jean Pei, Aoyama, Shinya, Makino, Saneyuki, Ferdinandus, Ferdinandus, Ng, Clara Shi Ya, Arai, Satoshi, Fujita, Hideaki, Tan, Hong Chang, Shibata, Shigenobu, Lee, Ken Chi-Lik

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High yield synthesis of graphene quantum dots from biomass waste as a highly selective probe for Fe3+ sensing by Abbas, Aumber, Tabish, Tanveer A., Bull, Steve J., Lim, Tuti Mariana, Phan, Anh N.

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Dynamic properties of high-Tc superconducting nano-junctions made with a focused helium ion beam by Couëdo, François, Amari, Paul, Feuillet-Palma, Cheryl, Ulysse, Christian, Srivastava, Yogesh Kumar, Singh, Ranjan, Bergeal, Nicolas, Lesueur, Jérôme

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Graph embeddings on gene ontology annotations for protein-protein interaction prediction by Zhong, Xiaoshi, Rajapakse, Jagath Chandana

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Controllable broadband multicolour single-mode polarized laser in a dye-assembled homoepitaxial MOF microcrystal by He, Huajun, Cui, Yuanjing, Li, Hongjun, Shao, Kai, Chen, Banglin, Qian, Guodong

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Validation of the Needs Assessment of Family Caregivers - cancer scale in an Asian population by Yang, Winson Fu Zun, Liu, Jianlin, Chan, Yiong Huak, Griva, Konstadina, Kuparasundram, Sangita, Mahendran, Rathi

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Three dimensional acoustic tweezers with vortex streaming by Li, Junfei, Crivoi, Alexandru, Peng, Xiuyuan, Shen, Lu, Pu, Yunjiao, Fan, Zheng, Cummer, Steven A.

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