The role of tumour necrosis factor alpha stimulated gene-6 on bone by Afrough, S

Characterizing the function of the Arl15 gene and its role in the development of metabolic traits by Bai, Y

“…The in vitro studies show a role for Arl15 in adipose tissue development.</p>…”

Use of static overpressure to assess the role of acoustic cavitation in ultrasound-mediated gene transfection by Ng, CK, Raymond, JL, Driscoll, C, Oldroyd, S, Huang, WE, Thompson, IP, Roy, RA

A regulatory role for repeated decoy transcription factor binding sites in target gene expression by Lee, Tek‐Hyung, Maheshri, Narendra

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Role of Interferon-stimulated gene 15 (ISG15) in replication fork progression and PARP inhibitor resistance in cancer by Seung, Y

“…Understanding PARP (Poly-ADP ribose polymerase) inhibitor resistance is crucial in cancer therapy, particularly in treating cancers associated with BRCA mutations. The role of ISG15 (Interferon-Stimulated Gene 15) in PARP inhibitor resistance adds a layer of complexity to this phenomenon. …”

Roles of POPX2 phosphatase in the regulation of apoptosis by Weng, Ting

“…The rigidity of matrix plays crucial roles in tumorigenesis. Physical signals provided by the substrates are sensed and conveyed by focal adhesions and actin cytoskeletons to the interior of the cell to elicit responses. …”
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The role of POPX2 in the regulation of hippo pathway by Muhammad Bakhait Rahmat

“…The Hippo pathway has gained immense attention due to its key role in regulating organ size as well as its relevance to tissue regeneration and cancer. …”
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The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…In order to address this need, the role of SPRTN in colorectal cancer chemotherapy is investigated for the first time in this thesis.…”

Understanding the role of Enterococcus faecalis in polymicrobial wounds by Davient, Bala

“…While Enterococcus faecalis is a lactic acid bacteria frequently detected in polymicrobial chronic wounds, its role in these wounds is unclear. I was therefore motivated to understand the role of E. faecalis in polymicrobial wounds, as the knowledge will guide evidence-based personalized wound therapies, enhancing treatment effectiveness, while reducing treatment costs. …”
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Role of polyamines in biofilm - based water decontamination by Chan, Henry Chun Loong

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The role of EZH2-VAV interaction in tumorigenesis by Wong, Jong Fu

“…We have previously identified a novel cytosolic role for EZH2 in the regulation of cell signaling via interaction with VAV family proteins; whether EZH2 interactions with the VAV are critical for tumorigenesis has not been explored. …”
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Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis by Ma, J

“…Altogether, this study provides the genetic evidence for the role of FIH in tumour suppression, which may result from its influence on the myeloid-mediated immune response. …”

Role of Tau and NRF2 in oxidative stress responses by Ameyaw, B

“…</p> <p>b) <strong>I identified a novel role for the Microtubulin Associated Protein Tau <em>(MAPT)</em> gene in protection against oxidative stress.…”

Elucidating the non-apoptotic role of the caspases in the Drosophila intestinal system by Arthurton, L

“…Taking advantage of the powerful genetic tractability of <em>Drosophila melanogaster</em>, I aimed to decipher the functional role of the caspases within the intestinal system, in addition to their role in tumour formation. …”

The role of membrane curvature in nanoscale topography-induced intracellular signaling by Lou, Hsin-Ya, Zhao, Wenting, Zeng, Yongpeng, Cui, Bianxiao

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Investigating the role of CDK1 in governing the transcriptional landscape in cancer cells by Pluta, AJ

“…Considering the need for temporal coordination of the cell cycle and the transcription cycle, it can be speculated that the CDKs might play a critical role in linking the two processes. Cyclin-dependent kinase 1 (CDK1) is a highly conserved essential regulator of mitosis, with recognised transcriptional functions revolving around the mitotic repression of gene expression. …”

Role of N-WASP in cell proliferation : implication for organ development and cancer by Verma, Apoorva

“…Further studies will be required to elucidate the mechanisms of N-WASP in lung cancer by validating the identified gene candidates and analysing their role in cell proliferation. …”
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Analyzing the roles of human U1 snRNA variants in pre-mRNA processing. by Goh, Eling.

“…Therefore, U1 variants are most likely not involved in 5’ss recognition but could have significant roles in IPA.…”
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BRCA1 regulation of breast cancer cell motility by Hernandez Nuñez, ZE

“…These models were used in conjunction with the siRNA knockdown of candidate proteins from the <em>in-silico</em> analysis. siRNA knockdown of SART3 significantly enhanced motility in cells lacking BRCA’s ubiquitin ligase activity, highlighting its potential role in promoting cell motility and emphasising the regulatory role of BRCA1’s ubiquitin ligase activity in breast cancer progression.…”

Investigating the role of lysine demethylase UTX-1 in lifespan regulation of C. elegans by Guillermo, A