Antimicrobial susceptibility and molecular profiles of acinetobacter baumannii in Makkah hospitals, and the potential use of bacteriophage as a treatment option by Raees, Fahad

“…This study also found 75.7% and 73.0% of the tested MDR A. baumannii isolated from Makkah hospitals acquired mph(E) and msr(E) macrolides resistant genes respectively. The aminoglycosides resistance was encoded mainly by aminoglycoside phosphor-transferase gene, aph(3′′)-Ib at 83.8% and aminoglycoside O-phosphotransferase aph(6)-Id at 70.3%. …”
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The opioid receptor influences circadian rhythms in human keratinocytes through the β-arrestin pathway by Bigliardi, Paul, Junnarkar, Seetanshu, Markale, Chinmay, Lo, Sydney, Bigliardi, Elena, Kalyuzhny, Alex, Ong, Sheena, Dunn, Ray, Wahli, Walter, Bigliardi-Qi, Mei

“…The recent emphasis on circadian rhythmicity in critical skin cell functions related to homeostasis, regeneration and aging has shed light on the importance of the PER2 circadian clock gene as a vital antitumor gene. Furthermore, delta-opioid receptors (DOPrs) have been identified as playing a crucial role in skin differentiation, proliferation and migration, which are not only essential for wound healing but also contribute to cancer development. …”
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Identification of novel interactions between MicroRNAs and pattern-recognition receptor signalling in dentritic cells by Pichulik, T

“…</p> <p>The work in these two chapters identifies a number of novel miR-650 targets and suggests a dual role for miR-650 in the innate immune response. Firstly, it is shown that miR-650 directly regulates a group of interferon-stimulated genes with known antiviral activity. …”

Heterogeneity within colorectal cancer cell lines and epigenetic regulation of CD24 by Ibn Ayub, M

“…This thesis investigated the role of methylation in dynamic regulation of CD24 based heterogeneity in colorectal cancer cell lines. …”

Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area by Nagaeva, Elina, Zubarev, Ivan, Gonzales, Carolina Bengtsson, Forss, Mikko, Nikouei, Kasra, de Miguel, Elena, Elsilä, Lauri, Linden, Anni-Maija, Hjerling-Leffler, Jens, Augustine, George James, Korpi, Esa R.

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Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress by Raghuraman, Radha, Navakkode, Sheeja, Sajikumar, Sreedharan

“…The hippocampal CA2 region has received greater attention in recent years due to its fundamental role in social memory and hippocampus-dependent memory processing. …”
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Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons by Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Vashisht, Ajay, Wohlschlegel, James A., Martin, Kelsey C.

“…Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. …”
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Wolbachia-mosquito interactions and engineered female-specific lethality for Aedes-arbovirus control by Molloy, JC

“…In Chapter 2, I examine in <em>Ae. albopictus</em> the hypothesis that reactive oxygen species (ROS) induced immune activation plays a role, but neither ROS nor innate immune pathways were upregulated. …”

Water quality and prevalence of extended spectrum beta lactamase producing escherichia coli (ESBL E. coli) in Sungai Terengganu, Malaysia by Noor Haza Fazlin Hashim, Muhammad Azroie Mohamed Yusoff, Rachel Trevor Gunggang, Roslina Abdul Razak, Muhamad Zulfatihi Jaafar, Nasehir Khan E.M. Yahaya

“…Water bodies, especially, are now recognized for their role in the spread of antimicrobial-resistant pathogens, though standardized monitoring methods are lacking. …”
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Comprehensive insights into Sitobion avenae preferences and performance on Pakistan’s wheat cultivars leading to identification of potential RNAi targets by Mukhtar, Ruhma, Afzal, Eijab, Noureen, Rabia, Zeeshan, Nadia, Afroz, Amber

“…Challenges like the development of insecticide resistance, the limited impact of insecticidal genes, and associated risks led to seeking a more precise approach like RNA interference. …”
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Chromosome-level genome assembly of the diploid blueberry Vaccinium darrowii provides insights into its subtropical adaptation and cuticle synthesis by Cui, Fuqiang, Ye, Xiaoxue, Li, Xiaoxiao, Yang, Yifan, Hu, Zhubing, Overmyer, Kirk, Brosché, Mikael, Yu, Hong, Salojärvi, Jarkko

“…This conserved genome structure may explain the high fertility observed during crossbreeding of V. darrowii with other blueberry cultivars. Analysis of gene expansion and tandem duplication indicated possible roles for defense- and flowering-associated genes in the adaptation of V. darrowii to the subtropics. …”
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Social Development / by Parke, Ross D., author 450250, Roisman, Glenn I., author 655021, Rose, Amanda J. (Amanda Janel), 1971-, author 655022, John Wiley & Sons (Online service) 647106

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A novel eukaryotic RdRP-dependent small RNA pathway represses antiviral immunity by controlling an ERK pathway component in the black-legged tick by Feng, Canran, Torimaru, Kyosuke, Lim, Mandy Yu Theng, Chak, Li-Ling, Shiimori, Masami, Tsuji, Kosuke, Tanaka, Tetsuya, Iida, Junko, Okamura, Katsutomo

“…Small regulatory RNAs (sRNAs) are involved in antiviral defense and gene regulation. Although roles of RNA-dependent RNA Polymerases (RdRPs) in sRNA biology are extensively studied in nematodes, plants and fungi, understanding of RdRP homologs in other animals is still lacking. …”
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TCR affinity biases Th cell differentiation by regulating CD25, Eef1e1, and Gbp2 by Kotov, Dmitri I., Mitchell, Jason S., Pengo, Thomas, Ruedl, Christiane, Way, Sing Sing, Langlois, Ryan A., Fife, Brian T., Jenkins, Marc K.

“…The affinity of the TCR interaction with p:MHCII plays a role in Th differentiation by mechanisms that are not completely understood. …”
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Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance by Mok, S., Ashley, E. A., Ferreira, P. E., Zhu, L., Lin, Z., Yeo, T., Chotivanich, K., Imwong, M., Pukrittayakamee, S., Dhorda, M., Nguon, C., Lim, P., Amaratunga, C., Suon, S., Hien, T. T., Htut, Y., Faiz, M. A., Onyamboko, M. A., Mayxay, M., Newton, P. N., Tripura, R., Woodrow, C. J., Miotto, O., Kwiatkowski, D. P., Nosten, F., Day, N. P. J., Preiser, P. R., White, N. J., Dondorp, A. M., Fairhurst, R. M., Bozdech, Z.

“…The expression profiles of UPR-related genes also associate with the geographical origin of parasite isolates, further suggesting their role in emerging artemisinin resistance in the Greater Mekong Subregion.…”
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Identification and functional analysis of Git3 G protein-coupled receptors in Ganoderma boninense PER71 by Khairunnisa Hanisah Mohd Daud, Mohd Faizal Abu Bakar, Izwan Bharudin, Shazilah Kamaruddin, Huai, Doris Xia Quay, Farah Diba Abu Bakar, Abdul Munir Abdul Murad

“…G protein-coupled receptors (GPCRs) are integral components of eukaryotic heterotrimeric G proteins, playing crucial roles in detecting extracellular signals and initiating the activity of signaling proteins within cells to activate cellular responses to these signals. …”
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Transient transmission of Chikungunya virus in Singapore exemplifies successful mitigation of severe epidemics in a vulnerable population by Hapuarachchi, Hapuarachchige Chanditha, Wong, Wing-Yan, Koo, Carmen, Tien, Wei-Ping, Yeo, Gladys, Rajarethinam, Jayanthi, Tan, Eugene, Chiang, Suzanna, Chong, Chee-Seng, Tan, Cheong-Huat, Tan, Li-Kiang, Ng, Lee Ching

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Genotype-specific expression and NLR repertoire contribute to phenotypic resistance diversity in Plantago lanceolata by Safdari, Pezhman, Höckerstedt, Layla, Brosche, Mikael, Salojärvi, Jarkko, Laine, Anna-Liisa

“…Nucleotide-binding leucine-rich repeat (NLR) genes play an important role in pathogen recognition, downstream defense responses and defense signaling. …”
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The habenula clock influences response to a stressor by Basnakova, Adriana, Cheng, Ruey-Kuang, Chia, Joanne Shu Ming, D'Agostino, Giuseppe, Suryadi, Tan, Germaine Jia Hui, Langley, Sarah Raye, Jesuthasan, Suresh

“…Two-photon calcium imaging indicates a circadian change in spontaneous activity of habenula neurons. To assess the role of this clock, a truncated clocka gene was specifically expressed in the habenula. …”
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Sonodynamic Nano-LYTACs reverse tumor immunosuppressive microenvironment for cancer immunotherapy by Xu, Mengke, Hu, Yuxuan, Wu, Jiayan, Liu, Jing, Pu, Kanyi

“…Extracellular and transmembrane proteins, which account for the products of approximately 40% of all protein-encoding genes in tumors, play a crucial role in shaping the tumor immunosuppressive microenvironment (TIME). …”
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