Targeting TFEB and TFE3 in iPSC-derived dopaminergic neurons to correct autophagic/lysosomal deficits in Parkinson's disease by McGuinness, W

“…Mutations in PD-related genes such as <em>GBA</em>, <em>LRRK2</em> and <em>SNCA</em> have all been implicated to present deficits in lysosomal catabolic pathways.…”

The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis by Ng, Shi-Yan, Bogu, Gireesh K., Soh, Boon Seng, Stanton, Lawrence Walter

“…Here, we provide mechanistic insight into the role of human RMST in modulating neurogenesis. RMST expression is specific to the brain, regulated by the transcriptional repressor REST, and increases during neuronal differentiation, indicating a role in neurogenesis. …”
Get full text
Get full text

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT by Seddon, C, David, S, Wong, JLC, Ishimoto, N, He, S, Bradshaw, J, Low, WW, Frankel, G, Beis, K

“…Conjugation plays a major role in dissemination of antimicrobial resistance genes. …”

Epigenetic analysis of hepatocellular carcinoma development : involvement of HBV-modulated DNA methylation by Niu, Dandan

“…DNA methylation, one of the mechanisms in epigenetics, affects gene expression at the transcriptional level. Evidence has revealed the association between HCC and HBV-mediated DNA methylation. …”
Get full text

Characterization of the translational regulation of BIM 3’ UTR by Ho, Jessie Jia Xin

“…Genomic variations of the BIM gene were shown to account for drug resistance. MicroRNAs (miRNA) play a role in post-transcriptional regulation by binding to the messenger RNA (mRNA) 3’ untranslated region (UTR) of protein coding genes which include BIM. …”
Get full text

Neuroprotective effect of tocotrienol-rich fraction and a-tocopherol of vitamin E against glutamate toxicity in neuronal cells and astrocytes by Selvaraju, Thilaga Rati

“…Human apoptosis quantitative PCR array analysis determined that post-treatment with 200 ng/mL TRF and α-TCP upregulated the anti-apoptotic genes and downregulated the pro-apoptotic genes in both the neuronal and astrocyte cell lines. …”
Get full text

Antimicrobial susceptibility and molecular profiles of acinetobacter baumannii in Makkah hospitals, and the potential use of bacteriophage as a treatment option by Raees, Fahad

“…This study also found 75.7% and 73.0% of the tested MDR A. baumannii isolated from Makkah hospitals acquired mph(E) and msr(E) macrolides resistant genes respectively. The aminoglycosides resistance was encoded mainly by aminoglycoside phosphor-transferase gene, aph(3′′)-Ib at 83.8% and aminoglycoside O-phosphotransferase aph(6)-Id at 70.3%. …”
Get full text

GOLDEN2-like1 is sufficient but not necessary for chloroplast biogenesis in mesophyll cells of C4 grasses by Lambret-Frotte, J, Smith, G, Langdale, J

“…Although previous characterization of golden2 (g2) mutants in maize has demonstrated a role for GLK2 paralogs in regulating chloroplast biogenesis in bundle sheath cells, the function of GLK1 has remained elusive. …”

Understanding perspectives and research trends in down syndrome neuropathogenesis: a bibliometric analysis by Huang, Tan, Lam, Xin-Jieh, Lim, Chong-Teik, Jusoh, Norhazlin, Fakurazi, Sharida, Cheah, Pike-See, Ling, King-Hwa

“…Notably, Alzheimer ’s-related genes and proteins play a pervasive role in DS neuropathological processes across patients' lifespans. …”
Get full text

Generation of lentiviral-mediated shRNA vectors to inhibit the expression of caspase-1 and Pycard/ASC in dendritic cells. by Tan, Bee Kim.

“…Recently, lentiviral vectors represented a tool to achieve a transient mode of gene-delivery to silence genes in hematopoetic cells. …”
Get full text

Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…This study focuses on Nurr1, an orphan nuclear receptor, due to its essential role in the survival and maintenance of dopaminergic neurons in the substantia nigra of the brain. …”
Get full text

Identification of microRNA targets for the alternative splicing isoforms of CD46. by Teo, Zhi Lin.

“…Some tumor cells are found to overexpress CD46, suggesting its probable role in cancer. Given the multitude roles of CD46, its regulation should have important implications in many biological processes. …”
Get full text

Actinorhodopsin: an efficient and robust light-driven proton pump for bionanotechnological applications by Ayoub, N, Djabeur, N, Harder, D, Jeckelmann, J, Ucurum, Z, Hirschi, S, Fotiadis, D

“…Actinorhodopsins are encoded by a distinct group of microbial rhodopsin (MR) genes predominant in non-marine actinobacteria. Despite their role in the global energy cycle and potential for bionanotechnological applications, our understanding of actinorhodopsin proteins is limited. …”

Assessment of gut microbiome variations in the mother and twin infant of captive white-handed gibbons (Hylobates lar) reveals the presence of beneficial and nonpathogenic bacteria by Badrul Munir Md-Zain, Siti Hajar Azmi, Roberta Chaya Tawie Tingga, Millawati Gani, Mohamad Khairulmunir, Abd Rahman Mohd-Ridwan

“…Next-generation sequencing (NGS) of the 16S rRNA gene was performed. The NGS data were analyzed on the basis of amplicon sequence variation. …”
Get full text

Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis by Noble, A, Motta, R, Cabras, S, Flores, BM, Nowak, J, Glapa-Nowak, A, Geremia, A, Satsangi, J, Culver, E

“…IgG4-SC and PSC shared 8 probes. Inflammatory genes (including CEP97, IFNAR1, TXK, HERC6, C5orf36, PYY, and MTRNR2L1) were predominantly involved in dysregulated methylation. …”

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Raj Murthi, S, Petry, A, Shashikadze, B, Stöckl, JB, Schmid, M, Santamaria, G, Klingel, K, Kračun, D, Chen, X, Bauer, S, Schmitt, JP, Flenkenthaler, F, Gorham, J, Toepfer, CN, Potěšil, D, Hruška, P, Zdráhal, Z, Mayer, Z, Klop, M, Lehmann, L, Qin, Y, Papanakli, L, Spielmann, N, Moretti, A

“…Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes coding for structural sarcomeric proteins, is the most common inherited heart disease. …”

The bHLH transcription factor OsPRI1 activates the Setaria viridis PEPC1 promoter in rice by Carvalho, P, Gomes, C, Gonçalves, I, Lourenço, TF, Vlad, D, Langdale, JA, Saibo, NJM

“…This promoter drives mesophyll-specific gene expression in rice. The role of OsPRI1 <i>in planta</i> was characterized using a rice line harbouring <i>SvPEPC1_pro::GUS</i>.…”

Nanoconfined β-sheets mechanically reinforce the supra-biomolecular network of robust squid sucker ring teeth by Guerette, Paul A., Hoon, Shawn, Ding, Dawei, Amini, Shahrouz, Masic, Admir, Ravi, Vydianathan, Venkatesh, Byrappa, Weaver, James C., Miserez, Ali

“…X-ray diffraction, nanomechanical, and micro-Raman spectroscopy measurements confirm that the modular design of the suckerins facilitates the formation of β-sheets of precise nanoscale dimensions and enables their assembly into structurally robust supramolecular networks stabilized by cooperative hydrogen bonding. The suckerin gene family has likely played a key role in the evolutionary success of decapodiform cephalopods and provides a large molecular toolbox for biomimetic materials engineering.…”
Get full text
Get full text

Genetic, natal, and spatial drivers of social phenotypes in wild great tits by Satarkar, D, Sepil, I, Sheldon, BC

“…</li> <li>Our results thus emphasise the role of non-genetic factors, particularly developmental and spatial variation, in shaping individual social behavioural tendencies.…”

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background by Nayak, S, Peto, TJ, Kucharski, M, Tripura, R, Callery, JJ, Quang Huy, DT, Gendrot, M, Lek, D, Nghia, HDT, van der Pluijm, RW, Dong, N, Long, LT, Vongpromek, R, Rekol, H, Hoang Chau, N, Miotto, O, Mukaka, M, Dhorda, M, von Seidlein, L, Imwong, M, Roca, X, Day, NPJ, White, NJ, Dondorp, AM

“…There is also a defined set of genes whose steady-state levels of mRNA and/or splice variants or antisense transcripts correlate with artemisinin resistance at the base level. …”