The role of the 235 kDA protein multigene family (py235) of the malaria parasite Plasmodium yoelii in invasion and host cell selection, virulence and immune evasion by Jayasree Kaveri Iyer

Get full text

Role of Sm3+ ions as network-modifying on elastic, mechanical, and radiation shielding properties of MgO–B2O3–TeO2 glasses by Zalamin, S.N.F., M Zaid, M.H., Matori, K.A., Karim, M.K.A., Yaakob, Y., Cheong, W.M., Loh, Z.W., Sayyed, M.I.

Get full text

Significant greenish-yellow emission from Dy3+/Sm3+ co-doped strontium-aluminate-telluro-borate glasses: role of Ag and CuO nanoparticles interplay by Abdullahi, Ibrahim, Hashim, Suhairul, Ghoshal, Sib K., Sayyed, Muhammad I., Thabit, Hammam A.

“…Thus, the absorption and emission characteristics of a new type of Dy2O3/Sm2O3-doped strontium–aluminate–telluro-borate glasses (prepared using the melt-quenching approach and characterized comprehensively) were customized by inserting copper oxide nanoparticles (CuONps) and silver nanoparticles (AgNps). …”

Revealing the potential role of hsa-miR-663a in modulating the PI3K-Akt signaling pathway via miRNA microarray in spinal muscular atrophy patient fibroblast-derived iPSCs by Gandhi, Gayatri, Kodiappan, Radha, Abdullah, Syahril, Teoh, Hoon Koon, Tai, Lihui, Cheong, Soon Keng, Yeo, Wendy Wai Yeng

“…Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder due to deletion or mutation of survival motor neuron 1 (SMN1) gene. Although survival motor neuron 2 (SMN2) gene is still present in SMA patients, the production of full-length survival motor neuron (SMN) protein is insufficient owing to missing or mutated SMN1. …”
Get full text

Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB by Fazli, Mustafa, Rybtke, Morten, Steiner, Elisabeth, Weidel, Elisabeth, Berthelsen, Jens, Groizeleau, Julie, Bin, Wu, Zhi, Boo Zhao, Yaming, Zhang, Kaever, Volkhard, Givskov, Michael, Hartmann, Rolf W., Eberl, Leo, Tolker-Nielsen, Tim

“…Our findings suggest that BerB binds c‐di‐GMP, and activates RpoN‐dependent transcription of the berA gene coding for a c‐di‐GMP‐responsive transcriptional regulator. …”
Get full text
Get full text

Assessment of novel pre-erythrocytic malaria vaccines in humans by Venkatraman, N

“…</p> <p>R21 has been developed at the Jenner Institute, University of Oxford. This is an improved RTS,S construct, an antigen derived from the pre-erythrocytic circumsporozoite protein, which is an abundant coat protein involved in sporozoite development and hepatocyte invasion. …”

The core- and pan-genomic analyses of the genus Comamonas : from environmental adaptation to potential virulence by Wu, Yichao, Zaiden, Norazean, Cao, Bin

“…In this study, we provide genomic insights into the potential ecological roles and virulence of Comamonas by analysing the entire gene set (pangenome) and the genes present in all genomes (core genome) using 34 genomes of 11 different Comamonas species. …”
Get full text
Get full text

TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to mediate seed oil biosynthesis by Kong, Que, Singh, Sanjay K., Mantyla, Jenny J., Pattanaik, Sitakanta, Guo, Liang, Yuan, Ling, Benning, Christoph, Ma, Wei

“…Cross-family transcription factor (TF) interactions play critical roles in the regulation of plant developmental and metabolic pathways. …”
Get full text

Transcriptomics of manually isolated Amborella trichopoda egg apparatus cells by Flores-Tornero, María, Proost, Sebastian, Mutwil, Marek, Scutt, Charles P., Dresselhaus, Thomas, Sprunck, Stefanie

“…Gene products include secreted proteins, such as small cysteine-rich proteins previously reported to act as extracellular signaling molecules with important roles during double fertilization. …”
Get full text

Using machine learning to discover candidate localised transcripts from microscopy and genome-wide bioinformatics data by Kiourlappou, M

“…After the production of labels, I present the figures using a novel visualisation tool which allows a user to explore the images alongside with the labels describing localisation for each gene and the different compartments examined for each gene. …”

Chromosome-level genome assembly of the diploid blueberry Vaccinium darrowii provides insights into its subtropical adaptation and cuticle synthesis by Cui, Fuqiang, Ye, Xiaoxue, Li, Xiaoxiao, Yang, Yifan, Hu, Zhubing, Overmyer, Kirk, Brosché, Mikael, Yu, Hong, Salojärvi, Jarkko

“…This conserved genome structure may explain the high fertility observed during crossbreeding of V. darrowii with other blueberry cultivars. Analysis of gene expansion and tandem duplication indicated possible roles for defense- and flowering-associated genes in the adaptation of V. darrowii to the subtropics. …”
Get full text

A novel eukaryotic RdRP-dependent small RNA pathway represses antiviral immunity by controlling an ERK pathway component in the black-legged tick by Feng, Canran, Torimaru, Kyosuke, Lim, Mandy Yu Theng, Chak, Li-Ling, Shiimori, Masami, Tsuji, Kosuke, Tanaka, Tetsuya, Iida, Junko, Okamura, Katsutomo

“…Small regulatory RNAs (sRNAs) are involved in antiviral defense and gene regulation. Although roles of RNA-dependent RNA Polymerases (RdRPs) in sRNA biology are extensively studied in nematodes, plants and fungi, understanding of RdRP homologs in other animals is still lacking. …”
Get full text

Origins and immunopathogenesis of autoimmune central nervous system disorders by Ramanathan, S, Brilot, F, Irani, SR, Dale, RC

“…First, we review non-modifiable risk factors, such as age, sex and ethnicity, as well as genetic factors such as monogenic variants, common variants in vulnerability genes and emerging HLA associations. Second, we highlight how interactions between environmental factors and epigenetics can modify disease onset and severity. …”

Novel loci and biomedical consequences of iron homoeostasis variation by Allara, E, Bell, S, Smith, R, Keene, SJ, Gill, D, Gaziano, L, Morselli Gysi, D, Wang, F, Tragante, V, Mason, A, Karthikeyan, S, Lumbers, RT, Bonglack, E, Ouwehand, W, Roberts, DJ, Dowsett, J, Ostrowski, SR, Larsen, MH, Ullum, H, Pedersen, OB, Brunak, S, Banasik, K, Erikstrup, C, Mitchell, J

“…Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. …”

Whole genome sequencing and comparative analysis of novel pathogen elizbethkingia anophelis against oxidative stress by Li, Yingying

“…Many putative virulence factors and antibiotic resistance genes were identified, underscoring the potential host–pathogen interactions and antibiotic resistance. …”
Get full text

Deubiquitinases in muscle physiology and disorders by Olie, CS, O'Brien, DP, Jones, HBL, Liang, Z, Damianou, A, Sur-Erdem, I, Pinto-Fernández, A, Raz, V, Kessler, BM

“…Several mutations in DUB encoding genes are linked to human NMDs, such as ATXN3, OTUD7A, UCHL1 and USP14, whilst other NMDs are associated with dysregulation of DUB expression. …”

Bacteriocin-like peptides encoded by a horizontally acquired island mediate Neisseria gonorrhoeae autolysis by Poncin, K, McKeand, SA, Lavender, H, Kurzyp, K, Harrison, OB, Roberti, A, Melia, C, Johnson, E, Maiden, MCJ, Greaves, DR, Exley, R, Tang, CM

“…Here, we searched for genes present in these 2 invasive species but not in other members of the Neisseria genus. …”

Elucidating the effects of DNA modification on transcription by Yavorska, O

“…Although gene silencing through promoter-proximal DNA methylation has been extensively described, the correlation between abundance of mC and hmC in gene bodies and expression is less well understood. …”

Molecular study of Rasd1 transcriptional regulation and Rasd1-NonO interaction. by Ong, Angeline Shufen.

“…Investigation via reporter gene assays, ChIP and gene knockdown suggest that Rasd1 modulates NonO to function as a co-repressor of the cAMP pathway by interacting at the cAMP response element (CRE) site of specific target genes – nuclear orphan receptor 4A (NR4A) 1 and 2. …”
Get full text

Influence of outer membrane c-type cytochromes on particle size and activity of extracellular nanoparticles produced by Shewanella oneidensis by Kjelleberg, Staffan, Cao, Bin, Ng, Chun Kiat, Sivakumar, Krishnakumar, Liu, Xin, Madhaiyan, Munusamy, Ji, Lianghui, Yang, Liang, Tang, Chuyang Y., Song, Hao

“…The metal-reducing bacterium Shewanella oneidensis is capable of reducing various metal(loid)s and produces nanoparticles (NPs) extracellularly, in which outer membrane c-type cytochromes (OMCs) have been suggested to play important roles. The objective of this study was to investigate the influence of the OMCs, that is, MtrC and OmcA, on the size and activity of the extracellular silver NPs (AgNPs) and silver sulfide NPs (Ag2S NPs) produced by S. oneidensis MR-1. …”
Get full text
Get full text