The gravity of the status quo: the response of research governance to system-level shocks by Derrick, GE, Robson, J, Oancea, A, Xu, X, Stan, M-R

Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.

“…Antigen-specific T-cell responses were also quantified by intracellular cytokine staining and flow cytometry. Older adults had attenuated T-helper (Th) response to vaccination, which was associated with weaker antibody responses and decreased SARS-CoV-2 neutralisation. …”
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Introducing Philosophy Through Pop Culture : From Socrates to Star Wars and Beyond / by Irwin, William, 1970-, editor 654991, Johnson, David Kyle, editor 654992, John Wiley & Sons (Online service) 647106

“…A closer examination, however, reveals that South Park is very much within the Platonic tradition, as Kyle and Stan engage in questioning and dialogue in order to "learn something today." …”
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Analysis of hepatocyte antigen presentation and T cell/hepatocyte interaction in the context of hepatitis B virus Infection. by Noviani, Maria.

“…Hepatitis B Virus (HBV) has evolved multiple immune escape strategies in order to establish persistent infection in the host. …”
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Phase transitions by an abundant protein in the anammox extracellular matrix mediate cell-to-cell aggregation and biofilm formation by Seviour, Thomas, Wong, Lan Li, Lu, Yang, Mugunthan, Sudarsan, Yang, Qiaohui, Chanda Segaran, Uma Shankari, Bessarab, Irina, Liebl, David, Williams, Rohan B. H., Law, Yingyu, Kjelleberg, Staffan

“…The Brosi_A1236 structure was computationally predicted to consist of immunoglobulin-like anti-parallel β-strands, and circular dichroism conducted on the isolated surface protein indicated that β-strands are the dominant higher-order structure. The isolated protein was stained positively by the β-sheet-specific stain thioflavin T, along with cell surface- and matrix-associated regions of the biofilm. …”
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Understanding the viral protein structures of clinically relevant arboviruses and fragment-based screening for antivirals by Farhana Abu Bakar

“…This could give a more holistic view of the protein’s function and mechanism, and open new avenues for antiviral development in the future. …”
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Techniques for analysis and integration of histology data and agent-based modelling of T cell-tumour interactions by Stephens, R

“…Immunotherapies are increasingly being developed to target aspects of the immune system, such as CD8+ T cells, in order to boost its anti-tumour response. In clinical trials of such therapies, patients are monitored in several ways, often including core-needle biopsies in which a small piece of the tumour is removed, stained for specific cell markers, and imaged.…”

Captions from Book Marks, a display held in Blackwell Hall, Weston Library, 24 August - 15 December 2024 by Honey, A, Evans, A, Fox, A

“…From paper clips, wine and ink stains, to burns from candles, added pilgrim’s badges, pressed plants, locks of hair and unusual objects used as bookmarks, the examples on display reveal hidden and often surprising habits of reading and writing. …”

In vivo visualization of cells with fluorescent-labeled fab fragment. by Wee, Armanda Lixuan.

“…Immunofluorescence has often been employed in in vivo imaging to understand the dynamic interaction of immune cells in physiological and pathological conditions. …”
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Development of hybrid antimicrobial nanomaterials by Lai, Kai Jun

“…These antibiotic resistant microbial are often known as the “superbugs” that made antibiotics in medicine less effective. …”
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Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells by Tan, Jerome, Chen, Jiahui, Roxby, Daniel, Chooi, Wai H., Nguyen, Tan D., Ng, Shi Y., Han, Jongyoon, Chew, Sing Y.

“…Despite its merits, iPSC differentiation into spinal cord progenitor cells (SCPCs) is variable, necessitating reliable assessment of differentiation and validation of cell quality and safety. Phenotyping is often performed via label-based methods including immunofluorescent staining or flow cytometry analysis. …”
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Correlative light and electron microscopy of telomeric repeat-binding factor 1 in mammalian cells by von Otter, Eric

“…Chromatin fibers range from 5 nm to 30 nm in diameter with a mean diameter of 18.5 nm which decreases to 13.1 nm in low salt conditions. In order to establish a comparative data-set of telomeric and non-telomeric chromatin, nucleosomes were stained for CLEM by eGFP_APEX2 labelling of H2B. …”
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Technological Innovation and Integration of Whole Brain Imaging, Olfactory Stimulation, and Correlative Microscopy in Larval Zebrafish by Swain, Corban N.

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Electrochemical scrutinizing techniques on initial development of pseudomonas aeruginosa strain (PAO1) biofilms by Foo, Yu Hao

“…The accumulation of biofilms on the surface of industrial equipment is natural yet often detrimental. In clinical settings, biofilms forming on medical implants pose health risks for patients with compromised immune systems; biofilms release a variety of virulence factors and are extremely resistant to antibiotics. …”
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Novel approaches for imaging-based diagnosis of ocular surface disease by Schmidl, Doreen, Schlatter, Andreas, Chua, Jacqueline, Tan, Bingyao, Garhöfer, Gerhard, Schmetterer, Leopold

“…Ocular surface disease is often synonymous with dry eye disease, but also refers to other conditions of the ocular surface, such as Meibomian gland dysfunction or keratitis and conjunctivitis with different underlying causes, i.e., allergies or infections. …”
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Spatial and temporal localization of cell wall associated pili in Enterococcus Faecalis by Choo, Pei Yi

“…We followed the distribution of Ebp and peptidoglycan (PG) at different growth stages of E. faecalis via immunofluorescence, along with fluorescent D-amino acids (FDAA) staining. Surprisingly, cell surface Ebp did not co-localize with newly synthesized PG. …”
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Experimenting Liver Fibrosis Diagnostic by Two Photon Excitation Microscopy and Bag-of-Features Image Classification by Stanciu, Stefan G., Xu, Shuoyu, Peng, Qiwen, Yan, Jie, Stanciu, George A., Welsch, Roy E., So, Peter T. C., Csucs, Gabor, Yu, Hanry

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Stomach tissue classification using autofluorescence spectroscopy and machine learning by Lim, Soo Y., Yoon, Hong M., Kook, Myeong-Cherl, Jang, Jin I., So, Peter T. C., Kang, Jeon W., Kim, Hyung M.

“…Abstract Background and objectives Determination of stomach tumor location and invasion depth requires delineation of gastric histological structure, which has hitherto been widely accomplished by histochemical staining. In recent years, alternative histochemical evaluation methods have been pursued to accelerate intraoperative diagnosis, often by bypassing the time-consuming step of dyeing. …”
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Growth of myxococcus xanthus in continuous-flow-cell bioreactors as a method for studying development by Smaldone, Gregory T., Jin, Yujie, Whitfield, Damion L., Mu, Andrew Y., Wong, Edward C., Wuertz, Stefan, Singer, Mitchell

“…To demonstrate the versatility of our growth environment, we carried out time-lapse confocal laser scanning microscopy to visualize M. xanthus biofilm growth and fruiting body development, as well as fluorescence staining of exopolysaccharides deposited by biofilms. …”
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Multi-spectral polarimetry imaging for early gastric cancer diagnosis by Wang, Wenfeng

“…This dissertation presents several studies in the development of polarimetry imaging techniques for gastric cancer diagnosis in order to approach the eventual goal of the detection of early gastric cancer in vivo in real time. …”
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