The study of radiotherapy resistance of hypoxic tumour for improving survival of cancer patient. by Goh, Yeek Teck.

“…Despite the advent of many new targeted cancer therapies, radiotherapy is still considered an important treatment modality in killing localised cancer cells. …”
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Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function by Liu, Y, Kretz, CA, Maeder, ML, Richter, CE, Tsao, P, Vo, AH, Huarng, MC, Rode, T, Hu, Z, Mehra, R, Olson, ST, Joung, JK, Shavit, JA

“…Genetic predisposition to thrombosis is still poorly understood, and we hypothesize that there are many additional risk alleles and modifying factors remaining to be discovered. …”

Identification of potent new brain cancer EGFR inhibitor from usimine A and usimine B: computer-aided drug design perspective by Roney, Miah, Issahaku, Abdul Rashid, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Brain cancer ranks 10th among cancer-related causes of death for patients worldwide. Medical chemists still have many challenges because of the high side effects, increasing tumor resistance, and low selectivity of new chemotherapeutic medications despite the enormous effort put out to extract, develop, and synthesize them. …”
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Surface composition dependent ligand effect in tuning the activity of nickel–copper bimetallic electrocatalysts toward hydrogen evolution in alkaline by Wei, Chao, Sun, Yuanmiao, Scherer, Günther G., Fisher, Adrian C., Sherburne, Matthew, Ager, Joel W., Xu, Zhichuan Jason

“…Unfortunately, the principles that governs alkaline HER performance remain unclear and are still under debate. By studying the alkaline HER at a series of NiCu bimetallic surfaces, where the electronic structure is modulated by ligand effect, we demonstrate that alkaline HER activity can be correlated with either the calculated or the experimental-measured d band center (an indicator of hydrogen binding energy) via a volcano-type relationship. …”
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Identification of alternative-splicing events in human monocyte differentiation by Sim, Donald Yuhui

“…The data obtained from RNA-seq still required verification through traditional methods, such as RT-PCR. …”
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Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum by Song, Yutong, Zhao, Zhihao, Xu, Linyu, Huang, Peiyuan, Gao, Jiayang, Li, Jingxuan, Wang, Xuejie, Zhou, Yiren, Wang, Jinhui, Zhao, Wenting, Wang, Likun, Zheng, Chaogu, Gao, Bo, Jiang, Liwen, Liu, Kai, Guo, Yusong, Yao, Xiaoqiang, Duan, Liting

“…Sustained mechanostimuli increase the levels of binding-immunoglobulin protein (BiP) expression and phosphorylated eIF2α, two markers for ER stress. …”
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Surface modified polymers for controlled macroscopic functions by Chng, S

“…In particular, drug delivery properties were investigated using hole-plate bioassays and HPLC-MS methods, and it was found that the antibiotic, Penicillin V, was still active after being loaded onto the polymer scaffolds, with surface modified polymers binding and releasing more drug than the corresponding controls. …”

Structural study of ribosome : 1) structural basis of EF-G in translocation. 2) molecular mechanism of ribosome-dependent toxin YoeB in mRNA cleavage by Chen, Yun

“…Binding with the ribosome and the GTP analogue facilitate the stabilization of EF-G switch I region, resulting in an ordered model of the active site. …”
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Supported Lipid Bilayer Platform To Test Inhibitors of the Membrane Attack Complex: Insights into Biomacromolecular Assembly and Regulation by Yorulmaz, Saziye, Jackman, Joshua Alexander, Hunziker, Walter, Cho, Nam-Joon

“…On the other hand, clusterin directly interacts with C5b-7 such that C5b-7 is still able to bind to the lipid bilayer, and clusterin affects the subsequent binding of other complement proteins involved in the MAC assembly. …”
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Engineering modular platforms for rapid vaccine development by Brune, K

“…Successfully decorating VLPs is still a major challenge. Genetic fusion or chemical modification is often time-consuming and can lead to misassembly or misfolding, which obstructs generation of the desired immune response. …”

Room-temperature continuous-wave vertical-cavity surface-emitting lasers based on 2D layered organic–inorganic hybrid perovskites by Zhang, Hongbo, Hu, Yuzhong, Wen, Wen, Du, Bowen, Wu, Lishu, Chen, Yu, Feng, Shun, Zou, Chenji, Shang, Jingzhi, Fan, Hong Jin, Yu, Ting

“…Two-dimensional (2D) layered lead halide perovskites with large exciton binding energies, efficient radiative recombination, and outstanding environmental stability are regarded as supreme candidates for realizing highly compact and ultralow threshold lasers. …”
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Synthesis, antimalarial activity, and molecular dynamic approaches of salophen metal complexes by Ali, Amatul Hamizah, Mukhtar, Nur Hafizah, Ling, Ng Yee, Norazmi, Nur Aqilah Zahirah, Agustar, Hani Kartini, Ling, Lau Yee, Abd Karim, Nurul Huda, Yusoff, Siti Fairus Mohd, Borzehandani, Mostafa Yousefzadeh, Hassan, Nurul Izzaty

“…Malaria is still one of the main infectious diseases in tropical climates. …”
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Genotype-specific expression and NLR repertoire contribute to phenotypic resistance diversity in Plantago lanceolata by Safdari, Pezhman, Höckerstedt, Layla, Brosche, Mikael, Salojärvi, Jarkko, Laine, Anna-Liisa

“…Molecular processes contributing to this variation in nature are still poorly known, although theory predicts resistance to evolve at specific loci driven by pathogen-imposed selection. …”
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Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…Importantly, the mechanisms underlying hepatic insulin signalling are still not completely understood.</p> <p>This project is focused on identifying genes involved in hepatic insulin action and aims at a more detailed molecular understanding of how defects in the signalling pathway may lead to insulin resistance. …”

Crack healing in reactive MgO-slag system via bacteria induced carbonate precipitation by Zheng, Yanying

“…In the Concrete industry, the most widely used binding ingredient for concrete, portland cement (PC), is accountable for around 8% of global anthropogenic carbon dioxide (CO2) emissions. …”
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Interpretable Computational Modeling of pre-mRNA Splicing for Multiple Eukaryotic Species by McCue, Kayla M.

“…Together these RNA elements and factors form an intricately interconnected regulatory system which is still incompletely understood. In this thesis, I describe SMsplice, an interpretable computational model of splicing that seeks to improve the understanding of how sequence elements influence the splicing pattern of pre-mRNA transcripts in a variety of eukaryotic organisms. …”
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Boosting hydrogen evolution reaction via electronic coupling of cerium phosphate with molybdenum phosphide nanobelts by Zhang, Luyao, Hu, Minghao, Li, Huan, Cao, Bo, Jing, Peng, Liu, Baocang, Gao, Rui, Zhang, Jun, Liu, Bin

“…Molybdenum phosphide (MoP) is regarded as one of the most promising alternatives to noble-metal based electrocatalysts for efficient hydrogen evolution reaction (HER) due to its similar d-band electronic structure to noble metals and tunable features associated with phase and composition. However, it still remains a great challenge to construct MoP electrocatalysts with abundant active sites that possess ideal H binding strength to promote catalytic performance. …”
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14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway by Mukherjee, Soumita, Roy, Somesh, Mukherjee, Shruti, Harikishore, Amaravadhi, Bhunia, Anirban, Mandal, Atin K.

“…Conversely, PDE8A activates the MAPK pathway by protecting CRAF/Raf1 kinase from PKA-mediated inhibitory phosphorylation at Ser259 residue, a binding site of scaffold protein 14-3-3. It still remains enigmatic as to how the cross-talk involving PDE8A regulation influences cAMP/PKA and MAPK signaling pathways. …”
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NMR structure and activity relationship of defensin-analogous peptides by Bai, Yang

“…Despite intensive research, detailed bactericidal and cytotoxic mechanisms of AMPs are still largely unknown. In this thesis, molecular template evolution based on the peptide sequence modifications, biophysical studies using fluorescence labeling and NMR spectroscopy, virtual screening utilizing large scale molecular dynamics simulations are exploited for rational antimicrobial drug discovery. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…The subsequent study using such clickable MVs as controlled drug/gene delivery vehicles is still in progress.…”
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