Developing a hollow fiber infection model system to determine the PK/PD of conjugated oligoelectrolytes against clinically relevant pathogens by Wang, Ruolan

“…Therefore, there is a pressing need for the development of novel drugs. One of the key stages in the drug discovery pipeline is understanding the pharmacokinetic/pharmacodynamic (PK/PD) of the new drug. …”
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Ellipsometry studies on anodic aluminium oxide (AAO)growth mechanism on high purity aluminium plate by Lim, Leng Khoon

“…This report presents the relationship between the anodizing parameters such as voltage, temperature and time and results such as film thickness and pores by using high purity aluminum plate. …”
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Surface modified polymers for controlled macroscopic functions by Chng, S

“…A library of polymers with variation in end group, and with expansion of substrate scope, was characterised in detail for chemical and macroscopic properties. In particular, drug delivery properties were investigated using hole-plate bioassays and HPLC-MS methods, and it was found that the antibiotic, Penicillin V, was still active after being loaded onto the polymer scaffolds, with surface modified polymers binding and releasing more drug than the corresponding controls. …”

Smart Microfluidic Devices for Point-Of-Care Applications by Julee Choudhary, Birendra Kumar, Durai, Sundararajan Ananiah, Ahmad, Nabihah

“…Microfluidics is an emerging technology vital in the bio-medical sector, encompassing LabOn-Chip (LOC), drug delivery, maladies diagnostic, and various healthcare fields. …”
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Smart Microfluidic Devices for Point-Of-Care Applications by Julee Choudhary, Birendra Kumar, Durai, Sundararajan Ananiah, Ahmad, Nabihah

“…Microfluidics is an emerging technology vital in the bio-medical sector, encompassing LabOn-Chip (LOC), drug delivery, maladies diagnostic, and various healthcare fields. …”
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A high-performance main-memory query engine on emerging many-core processors by Cheng, Xuntao

“…And, there are still significant rooms for further performance improvements. …”
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A biodegradable ocular implant for long-term suppression of intraocular pressure by Ng, Xu Wen, Liu, Kerh Lin, Veluchamy, Amutha Barathi, Lwin, Nyein Chan, Wong, Tina T., Venkatraman, Subbu Subramanian

“…However, the topical mode of administration (eyedrops) is far from optimal because of the issues of low bioavailability, high drug wastage, and lack of patient compliance. Suboptimal control of the IOP leads to disease progression and eventually to blindness. …”
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

“…In the second part, I have examined the molecular events underlying drug-induced adaptation, the process by which drug exposure inadvertently drives upregulation of pro-survival signaling pathways. …”
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Electrospinning pure protein solutions in core-shell fibers by Tiwari, Sandeep Kumar, Venkatraman, Subbu S.

“…However, the limitation of loading capacity still remains due the prerequisite of using an additional polymer as additive to achieve the minimum viscosity of the core solution required for viscous drag by the shell solution being drawn by the electrostatic force. …”
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15.269 Literature, Ethics and Authority, Fall 2005 by Hafrey, Leigh

“…Readings include work by Robert Bolt, Jane Smiley, Virginia Woolf, Ursula LeGuin, Wole Soyinka, and others; films include "Three Kings," "Crouching Tiger, Hidden Dragon," "Hotel Rwanda," and others. …”
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Enhancing breast cancer treatment: investigating the influence of polymer ratios on Luteolin-loaded TPGS/poloxamer micelles by Mod Razif, Muhammad Redza Fahmi, Liew, Kai Bin, Chan, Siok Yee, Chew, Yik Ling, Hassan, Masriana, Ahmad Hisham, Shairyzah, Abdul Rahman, Shamima, Kee, Phei Er

“…This study aimed to optimize luteolin-loaded TPGS/Pol micelles developed using the film hydration method, followed by lyophilization. …”
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NMR structure and activity relationship of defensin-analogous peptides by Bai, Yang

“…Despite intensive research, detailed bactericidal and cytotoxic mechanisms of AMPs are still largely unknown. In this thesis, molecular template evolution based on the peptide sequence modifications, biophysical studies using fluorescence labeling and NMR spectroscopy, virtual screening utilizing large scale molecular dynamics simulations are exploited for rational antimicrobial drug discovery. …”
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Identification of novel therapeutic candidates to treat autoimmune diseases by Lim, Eugene Hui Kiat

“…However, the mechanism of interactions is still unclear, and is a potential area for future research of this field.…”
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Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…The function of the NPC1 protein still remains poorly understood and how the NPC1 or NPC2 proteins interact, or the functions of the pathways they regulate still remains unknown. …”

The study of radiotherapy resistance of hypoxic tumour for improving survival of cancer patient. by Goh, Yeek Teck.

“…Despite the advent of many new targeted cancer therapies, radiotherapy is still considered an important treatment modality in killing localised cancer cells. …”
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Hybrid, nanoscale phospholipid/block copolymer vesicles by Lim, Seng Koon, Hoog, Hans-Peter de, Nallani, Madhavan, Bo, Liedberg, Parikh, Atul N.

“…In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.…”
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Thermal-disrupting interface mitigates intercellular cohesion loss for accurate topical antibacterial therapy by Hu, Benhui, Berkey, Christopher, Feliciano, Timothy, Chen, Xiaohong, Li, Zhuyun, Chen, Chao, Amini, Shahrouz, Nai, Mui Hoon, Lei, Qun-Li, Ni, Ran, Wang, Juan, Leow, Wan Ru, Pan, Shaowu, Li, Yong-Qiang, Cai, Pingqiang, Miserez, Ali, Li, Shuzhou, Lim, Chwee Teck, Wu, Yun-Long, Odom, Teri W., Dauskardt, Reinhold H., Chen, Xiaodong

“…Bacterial infections remain a leading threat to global health because of the misuse of antibiotics and the rise in drug-resistant pathogens. Although several strategies such as photothermal therapy and magneto-thermal therapy can suppress bacterial infections, excessive heat often damages host cells and lengthens the healing time. …”
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Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers? by Høilund-Carlsen, Poul F., Alavi, Abass, Castellani, Rudolph J., Neve, Rachael L., Perry, George, Revheim, Mona-Elisabeth, Barrio, Jorge R.

“…Two antibodies, aducanumab and lecanemab, have been approved by the U.S. Food and Drug Administration, while a third, donanemab, is under review. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…Prediction of the next pandemic strain is still a major challenge as mechanisms of antigenic shift and the zoonotic nature of influenza viruses are still poorly understood. …”
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Indirect effects of the COVID-19 pandemic: A cause-of-death analysis of life expectancy changes in 24 countries, 2015 to 2022 by Polizzi, A, Zhang, L, Timonin, S, Gupta, A, Dowd, JB, Leon, DA, Aburto, JM

“…By 2022, life expectancy had still not returned to prepandemic levels in several countries. …”