Structural study of ribosome : 1) structural basis of EF-G in translocation. 2) molecular mechanism of ribosome-dependent toxin YoeB in mRNA cleavage by Chen, Yun

“…Binding with the ribosome and the GTP analogue facilitate the stabilization of EF-G switch I region, resulting in an ordered model of the active site. …”
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Supported Lipid Bilayer Platform To Test Inhibitors of the Membrane Attack Complex: Insights into Biomacromolecular Assembly and Regulation by Yorulmaz, Saziye, Jackman, Joshua Alexander, Hunziker, Walter, Cho, Nam-Joon

“…On the other hand, clusterin directly interacts with C5b-7 such that C5b-7 is still able to bind to the lipid bilayer, and clusterin affects the subsequent binding of other complement proteins involved in the MAC assembly. …”
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Engineering modular platforms for rapid vaccine development by Brune, K

“…Successfully decorating VLPs is still a major challenge. Genetic fusion or chemical modification is often time-consuming and can lead to misassembly or misfolding, which obstructs generation of the desired immune response. …”

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…The MS2-MCP system is used to insert into mRNAs of interest special structures to which RNA-binding proteins, fused to a fluorescent protein such as GFP, can then bind. …”

Room-temperature continuous-wave vertical-cavity surface-emitting lasers based on 2D layered organic–inorganic hybrid perovskites by Zhang, Hongbo, Hu, Yuzhong, Wen, Wen, Du, Bowen, Wu, Lishu, Chen, Yu, Feng, Shun, Zou, Chenji, Shang, Jingzhi, Fan, Hong Jin, Yu, Ting

“…Two-dimensional (2D) layered lead halide perovskites with large exciton binding energies, efficient radiative recombination, and outstanding environmental stability are regarded as supreme candidates for realizing highly compact and ultralow threshold lasers. …”
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Synthesis, antimalarial activity, and molecular dynamic approaches of salophen metal complexes by Ali, Amatul Hamizah, Mukhtar, Nur Hafizah, Ling, Ng Yee, Norazmi, Nur Aqilah Zahirah, Agustar, Hani Kartini, Ling, Lau Yee, Abd Karim, Nurul Huda, Yusoff, Siti Fairus Mohd, Borzehandani, Mostafa Yousefzadeh, Hassan, Nurul Izzaty

“…Malaria is still one of the main infectious diseases in tropical climates. …”
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Frame competition and climate change communication by Ong, Adeline Huilin, Neo, Eileen Hui Yan, Lim, Nigel Wen Bin, Loh, Clara Yi Jin

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Genotype-specific expression and NLR repertoire contribute to phenotypic resistance diversity in Plantago lanceolata by Safdari, Pezhman, Höckerstedt, Layla, Brosche, Mikael, Salojärvi, Jarkko, Laine, Anna-Liisa

“…Molecular processes contributing to this variation in nature are still poorly known, although theory predicts resistance to evolve at specific loci driven by pathogen-imposed selection. …”
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Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…Importantly, the mechanisms underlying hepatic insulin signalling are still not completely understood.</p> <p>This project is focused on identifying genes involved in hepatic insulin action and aims at a more detailed molecular understanding of how defects in the signalling pathway may lead to insulin resistance. …”

Interpretable Computational Modeling of pre-mRNA Splicing for Multiple Eukaryotic Species by McCue, Kayla M.

“…Together these RNA elements and factors form an intricately interconnected regulatory system which is still incompletely understood. In this thesis, I describe SMsplice, an interpretable computational model of splicing that seeks to improve the understanding of how sequence elements influence the splicing pattern of pre-mRNA transcripts in a variety of eukaryotic organisms. …”
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Boosting hydrogen evolution reaction via electronic coupling of cerium phosphate with molybdenum phosphide nanobelts by Zhang, Luyao, Hu, Minghao, Li, Huan, Cao, Bo, Jing, Peng, Liu, Baocang, Gao, Rui, Zhang, Jun, Liu, Bin

“…Molybdenum phosphide (MoP) is regarded as one of the most promising alternatives to noble-metal based electrocatalysts for efficient hydrogen evolution reaction (HER) due to its similar d-band electronic structure to noble metals and tunable features associated with phase and composition. However, it still remains a great challenge to construct MoP electrocatalysts with abundant active sites that possess ideal H binding strength to promote catalytic performance. …”
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14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway by Mukherjee, Soumita, Roy, Somesh, Mukherjee, Shruti, Harikishore, Amaravadhi, Bhunia, Anirban, Mandal, Atin K.

“…Conversely, PDE8A activates the MAPK pathway by protecting CRAF/Raf1 kinase from PKA-mediated inhibitory phosphorylation at Ser259 residue, a binding site of scaffold protein 14-3-3. It still remains enigmatic as to how the cross-talk involving PDE8A regulation influences cAMP/PKA and MAPK signaling pathways. …”
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Finding Bukit Brown. by Chee, Janie Alison Hui-Yen., Shiu, Pedro Pui Kar., Siti Nurbaya Rameh.

“…The documentary features Raymond Goh, a volunteer guide who recognises and appreciates the history interred in the hill. Goh explains the historical and cultural features of Bukit Brown. …”
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NMR structure and activity relationship of defensin-analogous peptides by Bai, Yang

“…Despite intensive research, detailed bactericidal and cytotoxic mechanisms of AMPs are still largely unknown. In this thesis, molecular template evolution based on the peptide sequence modifications, biophysical studies using fluorescence labeling and NMR spectroscopy, virtual screening utilizing large scale molecular dynamics simulations are exploited for rational antimicrobial drug discovery. …”
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Enantiomeric separation of racemic mixtures using chiral-selective and organic-solvent-resistant thin-film composite membranes by Ong, Chi Siang, Oor, Jia Zheng, Tan, Jonathan Shiliang, Chew, Jia Wei

“…However, engineering membranes for chiral molecular separation in harsh organic solvent environments is still a big challenge. In this study, we fabricated a novel thin-film composite nanofiltration membrane composed of (2-hydroxypropyl)-beta-cyclodextrin (HP-β-CD) as the chiral selector for the enantiomeric separation of racemic 1-phenylethanol chiral compounds in organic solvents. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…The subsequent study using such clickable MVs as controlled drug/gene delivery vehicles is still in progress.…”
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Kinetic modelling of 70S ribosome and F1-ATPase by Le, Quang Luan

“…It is the state just after ATP binding and before ADP release.…”
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Electrochemical DNA biosensor based on nanoporous alumina membrane by Deng, Jiajia

“…The sputter-coated platinum layer on each side of the membrane was still used as working and counter electrode respectively. …”
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Fusion of cultures plays a part in writing styles & translation by Chen, Lijun

“…Nevertheless, the strategy of domestication is still widely adopted and is the one of the guiding principles in this Capstone project. …”
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Going on from Picasso? Late modernism and the dynamics of history by Nelson, S

“…Each of my chapters analyses a cluster of such framing factors, the legacies of which are still with us today.</p>…”