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binding » finding (Expand Search), findings (Expand Search)
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21
Boosting hydrogen evolution reaction via electronic coupling of cerium phosphate with molybdenum phosphide nanobelts
Published 2022“…Molybdenum phosphide (MoP) is regarded as one of the most promising alternatives to noble-metal based electrocatalysts for efficient hydrogen evolution reaction (HER) due to its similar d-band electronic structure to noble metals and tunable features associated with phase and composition. However, it still remains a great challenge to construct MoP electrocatalysts with abundant active sites that possess ideal H binding strength to promote catalytic performance. …”
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Journal Article -
22
14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway
Published 2024“…Conversely, PDE8A activates the MAPK pathway by protecting CRAF/Raf1 kinase from PKA-mediated inhibitory phosphorylation at Ser259 residue, a binding site of scaffold protein 14-3-3. It still remains enigmatic as to how the cross-talk involving PDE8A regulation influences cAMP/PKA and MAPK signaling pathways. …”
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Journal Article -
23
NMR structure and activity relationship of defensin-analogous peptides
Published 2014“…Despite intensive research, detailed bactericidal and cytotoxic mechanisms of AMPs are still largely unknown. In this thesis, molecular template evolution based on the peptide sequence modifications, biophysical studies using fluorescence labeling and NMR spectroscopy, virtual screening utilizing large scale molecular dynamics simulations are exploited for rational antimicrobial drug discovery. …”
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Thesis -
24
Enantiomeric separation of racemic mixtures using chiral-selective and organic-solvent-resistant thin-film composite membranes
Published 2022“…However, engineering membranes for chiral molecular separation in harsh organic solvent environments is still a big challenge. In this study, we fabricated a novel thin-film composite nanofiltration membrane composed of (2-hydroxypropyl)-beta-cyclodextrin (HP-β-CD) as the chiral selector for the enantiomeric separation of racemic 1-phenylethanol chiral compounds in organic solvents. …”
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Journal Article -
25
Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo...
Published 2014“…The subsequent study using such clickable MVs as controlled drug/gene delivery vehicles is still in progress.…”
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Thesis -
26
Kinetic modelling of 70S ribosome and F1-ATPase
Published 2021“…It is the state just after ATP binding and before ADP release.…”
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Thesis-Doctor of Philosophy -
27
Electrochemical DNA biosensor based on nanoporous alumina membrane
Published 2014“…The sputter-coated platinum layer on each side of the membrane was still used as working and counter electrode respectively. …”
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Thesis -
28
Genetic and molecular characterisation of non-tissue culture adapted influenza B viruses detected in Singapore between 2004-2009
Published 2014“…Even so, the mechanism yielding this peptide is still unknown since caspase and MMP inhibitors did not have an effect in its expression. …”
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Thesis -
29
Biocementation of sand filled geotextile tubes
Published 2019“…The calcite crystals that produced from the reaction of bacteria and cementitious solution are able to bind the aggregates and reduce the pores and thus reduce its water conductivity. …”
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Final Year Project (FYP) -
30
Methodology development and synthesis of a biologically relevant natural product and targeted scaffold discovery for serine hydrolase inhibition
Published 2016“…</p> <p>The exploration of serine hydrolases, an important mammalian enzyme class with a large portion still uncharacterized, requires inhibitors with new chemotypes that can covalently and irreversibly bind. …”
Thesis -
31
Functional metagenomic analysis of quorum sensing signaling in a nitrifying community
Published 2021“…However, the role of QS in such complex communities is still not fully understood, including the QS-proficient taxa and the functional QS genes involved. …”
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Journal Article