A comparative analysis of ENCODE and Cistrome in the context of TF binding signal by Perna, Stefano, Pinoli, Pietro, Ceri, Stefano, Wong, Limsoon

“…Finally, we provide a set of practices and guidelines, based on the signalValue feature, for scientists who wish to compare and merge narrowPeaks from ENCODE and Cistrome. Conclusions: The signalValue feature is an informative feature that can be effectively used to highlight consistent areas of overlap between different sources of TF binding sites that expose it. …”
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Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology by Ferla, MP, Sánchez-García, R, Skyner, RE, Gahbauer, S, Taylor, JC, von Delft, F, Marsden, BD, Deane, CM

“…This approach works under the assumption of conserved binding: when a larger molecule is designed containing the initial fragment hit, the common substructure between the two will adopt the same binding mode. …”