Field relations, petrogenesis and emplacement of the Bhagirathi leucogranite, Garhwal Himalaya by Searle, M, Metcalfe, RP, Rex, AJ, Norry, MJ

“…The roof complex shows numerous stoped blocks, xenoliths and elongate rafts of host rock in the top 100 m together with an extensive zone of layer-parallel leucogranite veining.…”

Homology modeling and expression of recombinant NS5-RDRP based on the Indonesian local strain of dengue virus for anti-dengue drug development by Subroto, Toto, Firdaus, Ade Rizqi Ridwan, Kusumawardani, Shinta, Tohari, Taufik Ramdani, Nababan, Theresia Adventina, Pertiwi, Wulan, Fadhlillah, Muhammad, Kusuma, Sri Agung Fitri, Rukayadi, Yaya

“…The isolated NS5-RdRp gene from the local strain was then inserted into the pET28a(+) plasmid and transformed into E. coli BL21(DE3) as the host cell. Recombinant NS5-RdRp was predominantly found in the insoluble fraction with a molecular weight of 72 kDa. …”
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Intermittent actuation attenuates fibrotic behaviour of myofibroblasts by Ward, Niamh A., Hanley, Shirley, Tarpey, Ruth, Schreiber, Lucien H.J., O'Dwyer, Joanne, Roche, Ellen T., Duffy, Garry P., Dolan, Eimear B.

“…The fibrotic capsule can be deleterious to the function of some medical implants as it can isolate the implant from the host environment. Modulation of fibrotic capsule formation has been achieved using intermittent actuation of drug delivery implants, however the mechanisms underlying this response are not well understood. …”
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Expanding the CRISPR Toolbox for Engineering Lycopene Biosynthesis in Corynebacterium glutamicum by Zhan, Zhimin, Chen, Xiong, Ye, Zhifang, Zhao, Ming, Li, Cheng, Gao, Shipeng, Sinskey, Anthony J., Yao, Lan, Dai, Jun, Jiang, Yiming, Zheng, Xueyun

“…Through the modifications between the host cell and the carotenogenic pathway, the lycopene yield was stepwise improved by 102-fold as compared to the starting strain. …”
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Screening of the PA14NR Transposon Mutant Library Identifies Genes Involved in Resistance to Bacteriophage Infection in Pseudomomas aeruginosa by Ho, Peiying, Dam, Linh Chi, Koh, Wei Ren Ryanna, Nai, Rui Si, Nah, Qian Hui, Rajaie Fizla, Faeqa Binte Muhammad, Chan, Chia Ching, Aung, Thet Tun, Goh, Shin Giek, Fang, You, Lim, Zhining, Koh, Ming Guang, Demott, Michael, Boucher, Yann Felix, Malleret, Benoit, Gin, Karina Yew-Hoong, Dedon, Peter, Moreira, Wilfried

“…This study highlights the potential of transposon mutant libraries and forward-genetic screens in identifying key genes involved in phage-host interactions and resistance mechanisms. These findings support the development of innovative strategies for combating antibiotic-resistant pathogens.…”
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The cyclic AMP-Vfr signaling pathway in Pseudomonas aeruginosa is inhibited by cyclic di-GMP by Almblad, Henrik, Harrison, Joe J., Rybtke, Morten, Groizeleau, Julie, Givskov, Michael, Parsek, Matthew R., Tolker-Nielsen, Tim

“…The opportunistic human pathogen Pseudomonas aeruginosa expresses numerous acute virulence factors in the initial phase of infection, and during long-term colonization it undergoes adaptations that optimize survival in the human host. Adaptive changes that often occur during chronic infection give rise to rugose small colony variants (RSCVs), which are hyper-biofilm-forming mutants that commonly possess mutations that increase production of the biofilm-promoting secondary messenger cyclic di-GMP (c-di-GMP). …”
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Assessing mentoring : a scoping review of mentoring assessment tools in internal medicine between 1990 and 2019 by Ng, Yong Xiang, Koh, Zachary Yong Keat, Yap, Hong Wei, Tay, Kuang Teck, Tan, Xiu Hui, Ong, Yun Ting, Tan, Lorraine Hui En, Chin, Annelissa Mien Chew, Toh, Ying Pin, Shivananda, Sushma, Compton, Scott, Mason, Stephen, Kanesvaran, Ravindran, Krishna, Lalit

“…Background: Mentoring's success in enhancing a mentee's professional and personal development, and a host organisations' reputation has been called into question, amidst a lack of effective tools to evaluate mentoring relationships and guide oversight of mentoring programs. …”
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Controllable broadband multicolour single-mode polarized laser in a dye-assembled homoepitaxial MOF microcrystal by He, Huajun, Cui, Yuanjing, Li, Hongjun, Shao, Kai, Chen, Banglin, Qian, Guodong

“…Here, we demonstrate a single crystal with multiple segments based on the host-guest metal-organic framework ZJU-68 hierarchically hybridized with different dye molecules generating controllable single-mode green, red, and near-infrared lasing, with the lasing mode mechanism revealed by computational simulation. …”
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Vitamin D modulates human macrophage response to Mycobacterium tuberculosis DNA by Cervantes, Jorge L., Oak, Esther, Garcia, John, Liu, Hongfei, Lorenzini, Paolo A., Batra, Deepika, Chhabra, Arvind, Salazar, Juan C., Roca, Xavier

“…Mycobacterium tuberculosis (Mtb) is a facultative intracellular pathogen that infects macrophages where it avoids elimination by interfering with host defense mechanisms, including phago-lysosome fusion. …”
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Probing the influence of tether density on tethered bilayer lipid membrane (tBLM)-peptide interactions by Park, Soohyun, Yorulmaz, Saziye Avsar, Cornell, B., Ferhan, Abdul Rahim, Jeon, W. Y., Chung, M., Cho, Nam-Joon

“…Tethered bilayer lipid membranes (tBLMs) represent a promising model membrane system that can host transmembrane proteins to serve as biosensors with exceptional detection performance. …”
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Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome by Dziekan, Jerzy Michal, Wirjanata, Grennady, Dai, Lingyun, Go, Ka Diam, Yu, Han, Lim, Yan Ting, Chen, Liyan, Wang, Loo Chien, Puspita, Brenda, Prabhu, Nayana, Sobota, Radoslaw M., Nordlund, Pär, Bozdech, Zbynek

“…Methodological optimizations necessary for the analysis of this intracellular parasite are discussed, including enrichment of parasitized cells and hemoglobin depletion strategies to overcome high hemoglobin abundance in the host red blood cells. We outline an effective data processing workflow using the mineCETSA R package, which enables prioritization of drug-target candidates for follow-up studies. …”
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Injectable cell transplantation system for cytokine-based cancer immunotherapy by Gerard Nathanael Adrianus.

“…Immunotherapy is a promising therapy that attempts to use components of the immune system to bolster host immune rejection against tumour tissues. Cytokines, the regulatory peptides that control modulation of cell proliferation, differentiation, and survival, have been widely studied for cancer immunotherapy. …”
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Identification of potential common cyclic-di-GMP regulated biomarkers among three gram negative bacteria via transcriptomic and metabolomic profiling by Cai, Zhao

“…Biofilm infections can evade host immune attack and develop into chronic conditions, which cannot be efficiently eradicated by conventional antimicrobial treatments. …”
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Development of immune-modulatory RNAS to regulate RIG-I-like receptors mediated antiviral immune response for therapy and vaccination by Yong, Hui Yee

“…Retinoic Acid-Inducible Gene I (RIG-I) is a cytosolic pattern recognition receptor (PRR) involved in initiating host defence response against viruses. RIG-I distinguishes between self and foreign nucleic acids by recognising chemical features not found in endogenous cytoplasmic RNA. …”
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Signatures of a time-reversal symmetric Weyl semimetal with only four Weyl points by Belopolski, Ilya, Yu, Peng, Sanchez, Daniel S., Ishida, Yukiaki, Chang, Tay-Rong, Zhang, Songtian S., Xu, Su-Yang, Zheng, Hao, Chang, Guoqing, Bian, Guang, Jeng, Horng-Tay, Kondo, Takeshi, Lin, Hsin, Liu, Zheng, Shin, Shik, Hasan, M. Zahid

“…Through intense research on Weyl semimetals during the past few years, we have come to appreciate that typical Weyl semimetals host many Weyl points. Nonetheless, the minimum nonzero number of Weyl points allowed in a time-reversal invariant Weyl semimetal is four. …”
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Optimising the surveillance and control of communicable diseases: the effects of population heterogeneity on early outbreak transmission dynamics by Lovell-Read, F

“…To overcome this, `sentinel' plants - alternative susceptible host species that display visible symptoms of infection more rapidly - could be introduced to at-risk populations and included in monitoring programmes to act as early warning beacons for infection. …”

Gametocyte carriage in uncomplicated plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual pat... by Abdulla, S, Achan, J, Yeka, A, D'Alessandro, U, Adam, I, Alemayehu, B, Allan, R, Temu, E, Allen, E, Barnes, K, Anvikar, A, Valecha, N, Arinaitwe, E, Ashley, E, Carrara, V, McGready, R, Nosten, F, Lee, S, White, N, Asih, P, Awab, G, Dondorp, A, Fanello, C, Woodrow, C, Dahal, P, Guerin, P, Humphreys, G, Moreira, C, Nsanzabana, C, Price, R, Sibley, C, Stepniewska, K, Bassat, Q, Gonzalez, R, Baudin, E, Checchi, F, Espie, E, Grandesso, F, Nabasumba, C, Schramm, B, Björkman, A, Bompart, F, Lameyre, V, Bonnet, M, Borrmann, S, Bousema, T, Cenci, F, Cot, M, Faucher, J, Kapulu, M, Marsh, K, Mayxay, M, Newton, P, Roper, C, Deloron, P, Djimde, A, Fofana, B, Doumbo, O, Sagara, I, Dorsey, G, Rosenthal, P, Drakeley, C

“…Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. …”

Enhancement of lentiviral vector production through alteration of virus-cell interactions by Gelinas, J

“…The focus then shifted to reducing, or 'knocking-down', inhibitory factors present in the host cells, which could adversely affect viral titres. …”

Efficient and Homogenous Precipitation of Sulfur Within a 3D Electrospun Heterocatalytic Rutile/Anatase TiO2-x Framework in Lithium–Sulfur Batteries by Feng, Ping, Dong, Kang, Xu, Yaolin, Zhang, Xia, Jia, Haojun, Prell, Henrik, Tovar, Michael, Manke, Ingo, Liu, Fuyao, Xiang, Hengxue, Zhu, Meifang, Lu, Yan

“…This study presents an innovative approach to developing free-standing sulfur host materials that are well suited for flexible Li–S batteries as well as for various other energy applications. …”
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Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore by Ivan, Fransiskus Xaverius, Zhou, Xinrui, Lau, Suk Hiang, Rashid, Shamima, Teo, Jasmine S. M., Lee, Hong Kai, Koay, Evelyn S., Chan, Kwai Peng, Leo, Yee Sin, Chen, Mark I. Cheng, Kwoh, Chee Keong, Chow, Vincent T.

“…Furthermore, we observed a trend in which the HA proteins of influenza A/H3N2 and A/H1N1 exhibited enhanced ability to bind both avian and human host cell receptors. In contrast, the binding ability to each receptor was relatively stable for the HA of influenza B. …”
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