Green amorphous nanoplex as a new supersaturating drug delivery system by Cheow, Wean Sin, Hadinoto, Kunn

“…The solubility of curcumin as the least-soluble drug is magnified 9-fold upon its transformation to the nanoplex, and the supersaturated condition is maintained for 5 h.…”
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Efficacy and safety of rapid-acting insulin analogs in special populations with Type 1 Diabetes or Gestational Diabetes: systematic review and meta-analysis by Nørgaard, Kirsten, Sukumar, Nithya, Rafnsson, Snorri Bjorn, Saravanan, Ponnusamy

“…In the pregnancy group, insulin lispro and insulin aspart were safe and effective for both mother and fetus, with glycemic control being at least as good as with RHI. There were no data on insulin glulisine during pregnancy. …”
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Sustainable performance through digital supply chains in industry 4.0 era: amidst the pandemic experience by Joshi, Sudhanshu, Sharma, Manu

“…Confirmatory factor analysis (CFA) confirms the constructs and the mediating effect of the DSCs through partial least squares structural equation modeling (PLS-SEM). …”
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Cloud Spark Cluster to analyse English prescription big data for NHS intelligence by Fernando, Sandra, Sowinski-Mydlarz, Viktor, Virdee, Bal Singh

“…Spark is a large-scale data processing engine that is at least a hundred times faster than the Hadoop big data processing engine. …”
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Exploring machine learning models for age recognition by Dharmarathne, Chathuranga, Ouazzane, Karim, Shrestha, Subeksha, Fernando, Sandra

“…The model built using random forest algorithm was the highest accurate model of 60% and the SVM was recorded least accuracy of 49% compared to other models. On the other hand, CNN without convolution layer has performed 71% accuracy against 54% accuracy.…”
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Young Europeans’ geo-political identities: a poststructural analysis by Ross, Alistair

“…This combination of multiple identities and recognising the importance of human rights values is most commonly found amongst young people who have grown up in multicultural societies, often urban, and the corollary of this is that combination is least likely to be found among the older population in more rural, monocultural settlements.…”
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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Osoti, V, Wamae, K, Ndwiga, L, Gichuki, PM, Okoyo, C, Kepha, S, Keitany, K, Kandie, R, Aricha, S, Kiplagat, R, Mwandawiro, C, Bejon, P, Snow, RW, Ochola-Oyier, LI

“…Conclusion: The genomic surveillance of asymptomatic school children in Kenya provides an early warning signal of at least 1 of the 3 validated artemisinin resistance mutations circulating in all regions in Western Kenya sampled except Homa Bay and Kisii Counties. …”

Symptom flares in women with chronic pelvic pain: questionnaire study within a cohort study (translational research in pelvic pain (TRiPP)) by Coxon, L, Lugt, C, Horne, AW, Evans, E, Abreu- Mendes, P, Arendt-Nielsen, L, Aziz, Q, Becker, CM, Birch, J, Charrua, A, Demetriou, L, Ferreira-Gomes, J, Hoffman, A, Hummelshoj, L, Krassowski, M, Lunde, CE, Meijlink, J, Missmer, SA, Perro, D, Zondervan, KT, Sieberg, CB, Cruz, F, Nagel, J, Vincent, K

“…Seventy-six per cent of women with CPP have ever experienced symptom flares of at least one length (short, medium and/or long). Flares are associated with painful and non-painful symptoms. …”

Clinical and neuroimaging markers of prodromal neurodegeneration in rapid eye movement sleep behaviour disorder by Barber, TR

“…</p> <p>We found that across a range of clinical prodromal features, RBD patients were at least as impaired as those with established Parkinson’s and that neuropsychiatric disorders were particularly prominent in RBD patients. …”

Most of the world's largest flowers (genus Rafflesia) are now on the brink of extinction by Malabrigo Jr, P, Tobias, AB, Witono, J, Mursidawati, S, Susatya, A, Siti-Munirah, MY, Wicaksono, A, Raihandhany, R, Edwards, S, Thorogood, CJ

“…Moreover, we predict that at least 67% of known habitats fall outside protected areas, exacerbating their vulnerability. …”

Adaptation of the WHO AWaRe (Access, Watch, Reserve) antibiotic classification to support national antimicrobial stewardship priorities in the UK: findings from a modified Delphi a... by Bou-Antoun, S, Oettle, RC, Leanord, A, Seaton, RA, Cooper, BS, Muller-Pebody, B, Conlon-Bingham, G, Kerr, F, Hand, KS, Sandoe, JAT, Llewelyn, MJ, Fleming, N, Brown, NM, Reid, N, Howard, P, Mckinstry, S, Malcolm, W, Demirjian, A, Ashiru-Oredope, D

“…Consensus was most easily reached, with least between-expert variation, for Access antibiotics. …”

15th-century printed Italian editions of Aesopian texts by Malaspina, M

“…</p> <p>It highlights how the introduction of the new medium did not correspond, at least within the first decades, to a standardisation in the written circulation of the rich Aesopian corpus; on the contrary, it fostered the composition of new versions, translations and rewritings, contributing to enhance its varied and multiform nature. …”

On the weak convergence of stochastic integrals on Skorokhod space: From general theory to applications within the realm of continuous-time random walks by Wunderlich, F

“…For stochastic integrals driven by strictly M1 convergent CTRWs and moving averages, where weak convergence may fail markedly, we determine natural classes of integrand processes that restore weak continuity. Not least, restricting to these classes yields functional limit theorems for certain stochastic delay differential equations driven by moving averages.…”

Emergency care knowledge, utilization, and barriers in Northern Tanzania: A community-based survey by Shayo, F, Zaccheus, GG, Sakita, F, Hernandes, TR, Vissoci, JRN, Gordee, A, Kuchibhatla, M, Kiremeji, M, Minja, L, Mmbaga, BT, Staton, CA, Keating, EM, Joiner, AP

“…The mean monthly household income was 226,107.6 Tanzanian Shillings. 76 (14.1%) households reported experiencing an emergency condition in the past year and 225 (41.7%) of respondents had an inappropriate response to at least one hypothetical emergency condition. A higher proportion of those with delayed access to healthcare paid with personal cash and a lower proportion had national health insurance. …”

Genotype-phenotype maps for gene networks: from evolution to computation by Camargo, FQ

“…<p>One of the most fundamental and least understood elements of evolution is the mapping between genotype and phenotype. …”

Networks of care for the modern adolescent by White, SR, Soneson, E, OxWell Study Team, Fazel, M

“…Informal sources had high acceptability, with around 80–90% reporting them as helpful, whereas child and adolescent mental health services (CAMHS), helplines, and online supports were perceived to be the least helpful. The networks also identified groups who might not be optimally served by current systems, including gender diverse adolescents and adolescents who found mental health support from their parents unhelpful.…”

A simple approach to improve recording of concerns about child maltreatment in primary care records: developing a quality improvement intervention by Woodman, J, Allister, J, Rafi, I, de Lusignan, S, Belsey, J, Petersen, I, Gilbert, R

“…<p><b>Results</b> The rate of children with at least one maltreatment-related code was 8.4/1000 child years (11 study practices, 2009–2010), and 8.0/1000 child years (THIN, 2009–2010). …”

Omega-3 fatty acid supply in pregnancy for risk reduction of preterm and early preterm birth by Cetin, I, Carlson, SE, Burden, C, da Fonseca, EB, di Renzo, GC, Hadjipanayis, A, Harris, WS, Kumar, KR, Olsen, SF, Mader, MS, McAuliffe, FM, Muhlhausler, B, Oken, E, Poon, LC, Poston, L, Ramakrishnan, U, Roehr, CC, Savona-Ventura, C, Smuts, CM, Sotiriadis, A, Su, K-P, Tribe, RM, Vannice, G, Koletzko, B, Clinical Practice Guideline

“…Women of childbearing age should obtain a supply of at least 250 mg/d of docosahexaenoic+eicosapentaenoic acid from diet or supplements, and in pregnancy an additional intake of ≥100 to 200 mg/d of docosahexaenoic acid. …”

Galaxy bias in the era of LSST: perturbative bias expansions by Nicola, A, Hadzhiyska, B, Findlay, N, García-García, C, Alonso, D, Slosar, A, Guo, Z, Kokron, N, Angulo, R, Aviles, A, Blazek, J, Dunkley, J, Jain, B, Pellejero, M, Sullivan, J, Walter, CW, Zennaro, M

“…We find both HEFT methods as well as LPT and EPT combined with non-perturbative predictions for the matter power spectrum to yield unbiased constraints on cosmological parameters up to at least a maximal scale of&nbsp;<em>k</em>_max&nbsp;=&nbsp;0.4&nbsp;Mpc^-1&nbsp;for all samples considered, even in the presence of assembly bias. …”

Soft law, hard stakes? State commitment to non-binding international instruments and the case of the UN Declaration on the Rights of Indigenous Peoples by Villeneuve, L

“…It is often assumed that its non-binding status upon adoption makes commitment to soft law a relatively inconsequential endeavor, at least in comparison to hard law. In this thesis, incorporating insights from public international law into rationalist IR approaches, I argue that soft law instruments can have important effects over time and bring substantial costs for states to bear. …”