Archaia Phusis: the original nature of the soul in Plato’s Middle Dialogues by Körner, H

“…Do we desire our fully realized state because it ‘belongs’ (is <em>oikeion</em>) to us or because it is good? Last but not least, what do we make of the fact that immortality and the theory of recollection seem to play no role in the <em>Symposium</em>? …”

The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…</p> <p><strong>Methods and analysis:</strong> Patients with newly diagnosed PsA and at least one poor prognostic factor (polyarthritis, C-reactive protein >5 mg/dL, health assessment questionnaire >1, radiographic erosions) were randomized equally and open-label to either standard care with ‘step-up’ csDMARD therapy, initial therapy with combination csDMARDs (methotrexate with either sulfasalazine or leflunomide) or to early biologics induction therapy (adalimumab plus methotrexate). …”

Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19 (COVIC-19): protocol for a randomised, open-label trial by Desmarets, M, Hoffmann, S, Vauchy, C, Rijnders, BJA, Toussirot, E, Durrbach, A, Körper, S, Schrezenmeier, E, van der Schoot, CE, Harvala, H, Brunotte, G, Appl, T, Seifried, E, Tiberghien, P, Bradshaw, D, Roberts, DJ, Estcourt, LJ, Schrezenmeier, H

“…Up to 1020 participants will be enrolled in each cohort (at least 340 with a sample size re-estimation after reaching 102 patients). …”

Canadians' opinions towards COVID-19 data-sharing: a national cross-sectional survey by Savić Kallesøe, SA, Rabbani, T, Gill, EE, Brinkman, F, Griffiths, EJ, Zawati, M, Liu, H, Palmour, N, Joly, Y, Hsiao, WWL

“…Generally supportive Canadians were characterised as being ≥50 years, with higher education, and being vaccinated against COVID-19 at least once. Vaccination status was the most influential predictor of data-sharing opinion, with respondents who were ever vaccinated being 4.20 times more likely (95% CI 3.21 to 5.48, p=0.000) to be generally supportive of data-sharing than those unvaccinated. …”

The fragmented COVID-19 therapeutics research landscape: a living systematic review of clinical trial registrations evaluating priority pharmacological interventions by McLean, ARD, Rashan, S, Tran, L, Arena, L, Lawal, A, Maguire, BJ, Adele, S, Antonio, ES, Brack, M, Caldwell, F, Carrara, VI, Charles, R, Citarella, BW, Epie, TB, Feteh, VF, Kennon, K, Makuka, GJ, Ngu, R, Nwosu, A-P, Obiesie, S, Ogbonnaa-Njoku, C, Paul, P, Richmond, C, Singh-Phulgenda, S, Strudwick, S, Tyrrell, CSB, Stepniewska, K, Strub-Wourgaft, N, White, NJ, Guérin, PJ

“…</p> <p><strong>Results:</strong> We identified 1,314 registered studies that included at least one of the 32 priority pharmacological interventions. …”

The effectiveness of individualized morphosyntactic target identification and explicit intervention using the SHAPE CPDING System for children with developmental language disorder... by Ebbels, SH, Gadd, M, Nicoll, H, Hughes, L, Burke, C, Dawson, N, Calder, SD, Frizelle, P

“…</p> <br> <p><strong>METHOD:</strong> Eight children with developmental language disorder aged 8;0-10;10 (years;months) received 10 hr of explicit individualized intervention for morphosyntax delivered in 30-min individual sessions once per week for 20 weeks. Following at least four baseline probe tests, two grammatical targets per session received explicit instruction until they reached criterion (90%), when the next target was introduced. …”

'The listening series': increasing equity, diversity and inclusion in patient and public involvement and engagement for policy research by listening to and learning from under-repr... by Bevan, C, Alderdice, F, Darby, S, Gilzean-Hughes, S, McLeish, J, Mulla, S, Plachcinski, R, Wilkinson, S, Williams, H, Rowe, R

“…Research funders prioritise equality, diversity and inclusion (EDI) in patient and public involvement and engagement (PPIE), but people who are most likely to experience poor outcomes are also those least likely to be involved in research. This paper describes our experience of setting out to understand how to overcome barriers to EDI in PPIE in the research carried out by the National Institute for Health and Care Research (NIHR) Policy Research Unit in Maternal and Neonatal Health and Care (PRU-MNHC), in a PPIE consultation project we called The Listening Series. …”

Patterns of sub-optimal change following CBT for childhood anxiety by Bertie, L-A, Arendt, K, Coleman, JRI, Cooper, P, Cresswell, C, Eley, TC, Hartman, C, Heiervang, ER, In-Albon, T, Krause, K, Lester, KJ, Marin, CE, Nauta, M, Rapee, RM, Schneider, S, Schniering, C, Silverman, WK, Thastum, M, Thirwall, K, Waite, P, Wergeland, GJ, Hudson, JL

“…</p> <br> <p><strong>Methods:</strong> Data were collected from ten clinical sites with assessments at pre-and post-treatment, and at least once more at 3, 6, or 12-month follow-up. Participants were assigned to one of three groups based on diagnostic status for youths who: i) retained an anxiety diagnosis from post to end point (minimal responders); ii) remitted anxiety diagnoses at post but relapsed by end point (relapsed responders); and iii) retained a diagnosis at post but remitted to be diagnosis free at end point (delayed responders). …”

Multicenter double-blind study evaluating AI-driven detection of proximal deep vein thrombosis by Curry, N, Allen, E, Silsby, L, Goodacre, S, Deane, C, Deary, A, Foster, A, Griffiths, J, Sharma, R, Thomas, H, Mischewitz, S, Al-Noor, F

“…The costs for diagnosing deep vein thrombosis (DVT) in the UK are £175 million, annually. In at least 80% of cases, DVT is excluded. As health care provision becomes increasingly stretched, resource utilization needs to be optimized. …”

A study of human monoclonal antibodies to influenza and ebola viruses by Rijal, P

“…The response was more diverse, employing a wide selection of VH/L genes, and was directed at multiple epitopes in at least three distinct regions on the GP. Despite these features, half of the antibodies neutralised an Ebola surrogate virus <em>in vitro</em>, and many were therapeutic in a murine infection model. …”

Respiratory quality indices for automated monitoring of respiration from sensor data by Birrenkott, D

“…Despite this, RR is often the least monitored and most inaccurately measured vital sign. …”

The impact of natural climate variability on the global distribution of Aedes aegypti: a mathematical modelling study by Kaye, AR, Obolski, U, Sun, L, Hart, WS, Hurrell, JW, Tildesley, MJ, Thompson, RN

“…Each of these scenarios corresponds to a single climate projection, allowing us to explore the difference in Ae aegypti suitability between the most-suitable and the least-suitable projections. <p><b>Findings</b></p> Our key finding was that natural climate variability generates substantial variation in future projections of environmental suitability for Ae aegypti. …”

Effects of particle sizes on total catechin content and antioxidant activity of Musa paradisiaca inflorescence using supercritical carbon dioxide (SFE-CO2)) extraction by Qing, Chong Xiu, Hean, Chong Gun, Nik Hadzir, Noor Hadzuin

“…The results indicated that the smallest particles (450 - 600 µm) exhibited the highest total oil extraction yield (29.40 ± 7.95%) at 60°C; 45 M Pa, while 850 µm - 1600μm particles had the least (9.54 ± 1.60%) at 40°C; 45MPa. Extraction efficacy of SFE-CO2 at 45MPa; 60°C demonstrated a comparable effect (p &amp;gt; 0.05) to the 10-hour Sox let extraction. …”
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Leptospirosis modelling using hydrometeorological indices and random forest machine learning by Jayaramu, Veianthan, Zulkafli, Zed, De Stercke, Simon, Buytaert, Wouter, Rahmat, Fariq, Abdul Rahman, Ribhan Zafira, Ishak, Asnor Juraiza, Tahir, Wardah, Ab Rahman, Jamalludin, Mohd Fuzi, Nik Mohd Hafiz

“…The rainfall variable (extreme) was the most important in classifying the leptospirosis occurrence while streamflow was the least important despite showing higher correlations with leptospirosis.…”

Studies of seed-borne fungi of tropical pasture legume species by Nik, WZ, Parbery, DG

“…P. sorghina was also found in embryo and cotyledonary tissue and survived in infected seed for at least 5 years. One storage fungus, Aspergillus ruber, was a seed (embryo) pathogen. …”

Modelling and experimental analysis of aero-engine performance and exhaust emission characteristics fueled with green fuel blends by Abu Talib, Abd Rahim, S. M. Altarazi, Yazan, Yu, Jianglong, Gires, Ezanee, Fahmi Abdul Ghafir, Mohd, Tahmasebi, Arash, Yusaf, Talal, Alsultan, Abdulkareem G., Yunus, Robiah

“…GD10PME10 produced the lowest NOx (12.5 ppm) at maximum speed, while Jet-A1 emitted the least NOx (7.5 ppm) at 120 k RPM. Overall, the data suggested that green fuel might increase the physiochemical properties of biodiesel blends, hence improving the fuel's capacity to burn more effectively in aero-engines.…”
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Influence of knowledge, organisation culture and perceived characteristics of brand support behaviour policy mediated by social media adoption among microenterprise employees in Ma... by Halil, Nur Afni

“…SPSS and SmartPLS (Partial Least Squares-Structural Equation Modelling) were used in performing the analysis. …”
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Enhancing indoor positioning accuracy with WLAN and WSN: a QPSO hybrid algorithm with Surface tessellation by Scavino, Edgar, Abd Rahman, Mohd Amiruddin, Farid, Zahid, Ahmad, Sadique, Asim, Muhammad

“…For these reasons, a hybrid approach that employs at least two different signal typologies proved to be more effective, resilient, robust, and accurate in determining localization in indoor environments. …”
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Treatment of acute sore throat in Malaysia: a consensus of multidisciplinary recommendations using modified Delphi methodology by Abdullah, Baharudin, Koh, Kar Chai, Mohamed, Mohazmi, Tan, Vincent Eng Soon, Mohammad, Nurashikin, Sekawi, Zamberi, Periyasamy, Petrick, Ramadas, Anitha, Duerden, Martin

“…A consensus was reached if at least 70% of the group agreed with the statement. …”
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Preparation, antifungal potentiality, and mechanisms of action of agronanofungicides in controlling rice blast disease and enhancing yield of rice by Kutawa, Abdulaziz Bashir, Ahmad, Khairulmazmi, Hussein, Mohd Zobir, Ali, Asgar, Abdul Wahab, Mohd Aswad, Rafi, Amara, Gunasena, Mahesh Tiran, Mohd Zobir, Syazwan Afif, Berahim, Zulkarami

“…The results for the efficacy under glasshouse conditions showed that CHDEN was the most promising agronanofungicide in managing rice blast with disease severity index (19.80%), lesion length (1.63 cm), AUDPC (390.60 unit2), disease reduction (80.20%), and a protection index of 82.26%. The least effective fungicide was commercial ANV with a disease severity index of 45.60%, lesion length (3.83 cm), AUDPC (1205.75 unit2), disease reduction (54.40%), and a protection index (45.24%). …”