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    Fibrinogen, chronic obstructive pulmonary disease (COPD) and outcomes in two United States cohorts by Mannino DM, Müellerova H, Valvi D, Tal-Singer R

    Published 2012-03-01
    “…Deepa Valvi1, David M Mannino1,2, Hana Müllerova3, Ruth Tal-Singer41Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY, USA; 2Department of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky College of Medicine, Lexington, KY, USA; 3GlaxoSmithKline Research and Development, Worldwide Epidemiology, Stockley Park, Middlesex, UK; 4GlaxoSmithKline Research and Development, Respiratory Therapy Area Unit, King of Prussia, PA, USABackground: Fibrinogen is a marker of systemic inflammation and may be important in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD).Methods: We used baseline data from Atherosclerosis Risk in Communities and Cardiovascular Health Studies to determine the relation between fibrinogen levels and COPD and to examine how fibrinogen levels at baseline affected outcomes of death, development of COPD, lung function decline, and COPD-hospitalizations.Results: Our study sample included 20,192 subjects, of whom 2995 died during the follow-up period. …”
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