The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial by Kasturiratne, Anuradhani, Khawaja, Khadija I., Ahmad, Sajjad, Siddiqui, Samreen, Shahzad, Khurram, Athauda, Lathika K., Jayawardena, Ranil, Mahmood, Sara, Muilwijk, Mirthe, Batool, Tayyaba, Burney, Saira, Glover, Matthew, Palaniswamy, Saranya, Bamunuarachchi, Vodathi, Panda, Manju, Madawanarachchi, Suren, Rai, Baldeesh, Sattar, Iqra, Silva, Wnurinham, Waghdhare, Swati, Jarvelin, Marjo-Riitta, Rannan-Eliya, Ravindra P., Gage, Heather M., van Valkengoed, Irene G. M., Valabhji, Jonathan, Frost, Gary S., Loh, Marie, Wickremasinghe, Ananda R., Kooner, Jaspal S., Katulanda, Prasad, Jha, Sujeet, Chambers, John C.

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Forecasting annual maximum water level for the Negro River at Manaus using dynamical seasonal predictions by Amulya Chevuturi, Nicholas P. Klingaman, Steven J. Woolnough, Conrado M. Rudorff, Caio A.S. Coelho, Jochen Schöngart

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Recent advances in addressing the market failure of new antimicrobials: Learnings from NICE's subscription-style payment model by Marieke Schurer, Renu Patel, Marjolijn van Keep, Jake Horgan, Suzette Matthijsse, Matthew Madin-Warburton

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Advancing a Human Rights-Based Approach to Access to Medicines: Lessons Learned from the Constitutional Court of Peru by Lowri Davies

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Integrative Mendelian randomization reveals the soluble receptor for advanced glycation end products as protective in relation to rheumatoid arthritis by Gha Young Lee, Chen Yao, Shih-Jen Hwang, Jiantao Ma, Roby Joehanes, Dong Heon Lee, R. Curtis Ellison, Lynn L. Moore, Chunyu Liu, Daniel Levy

“…Genetic variants from three sources were obtained: those associated with 71 CVD-related proteins measured in nearly 7000 Framingham Heart Study participants, a published genome-wide association study (GWAS) of RA (19 234 cases, 61 565 controls), and GWAS of rheumatoid factor (RF) levels from the UK Biobank (n = 30 565). We identified the soluble receptor for advanced glycation end products (sRAGE), a critical inflammatory pathway protein, as putatively causal and protective for both RA (odds ratio per 1-standard deviation increment in inverse-rank normalized sRAGE level = 0.364; 95% confidence interval 0.342–0.385; P = 6.40 × 10–241) and RF levels (β [change in RF level per sRAGE increment] = − 1.318; SE = 0.434; P = 0.002). …”
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Treatment patterns for advanced non-small cell lung cancer in the US: A systematic review of observational studies by Adam Lee, Yong Yuan, Laura Eccles, Anushri Chitkara, Johan Dalén, Nebibe Varol

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Assessing Fracture Toughness and Impact Strength of PMMA Reinforced with Nano-Particles and Fibre as Advanced Denture Base Materials by Abdulaziz Alhotan, Julian Yates, Saleh Zidan, Julfikar Haider, Nikolaos Silikas

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Use of implementation science to advance family planning programs in low- and middle-income countries: A systematic review by Colin Baynes, Petrus Steyn, Caroline Soi, Aneth Dinis, Aneth Dinis, Stelio Tembe, Hedieh Mehrtash, Manjulaa Narasimhan, James Kiarie, Kenneth Sherr, Kenneth Sherr, Kenneth Sherr

“…Most studies used quantitative methods only and evaluated user-level outcomes over implementation outcomes. Thirty percent measured processes and outcomes of strategies, 15 percent measured changes in implementation outcomes, and 31 percent report on the effect of contextual factors. …”
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Harnessing the power of AI: Advanced deep learning models optimization for accurate SARS-CoV-2 forecasting. by Muhammad Usman Tariq, Shuhaida Binti Ismail, Muhammad Babar, Ashir Ahmad

“…The pandemic has significantly affected many countries including the USA, UK, Asia, the Middle East and Africa region, and many other countries. …”
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Evaluation of gene expression of transcription factors involved in salinity tolerance in Barley (Hordeum vulgare L.) advanced genotypes by Soraya Ghorbani, Alireza Etminan, Varahram Rashidi, Alireza Pour-Aboughadareh, Lia Shooshtari

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Level structures of 56,58Ca cast doubt on a doubly magic 60Ca by S. Chen, F. Browne, P. Doornenbal, J. Lee, A. Obertelli, Y. Tsunoda, T. Otsuka, Y. Chazono, G. Hagen, J.D. Holt, G.R. Jansen, K. Ogata, N. Shimizu, Y. Utsuno, K. Yoshida, N.L. Achouri, H. Baba, D. Calvet, F. Château, N. Chiga, A. Corsi, M.L. Cortés, A. Delbart, J.-M. Gheller, A. Giganon, A. Gillibert, C. Hilaire, T. Isobe, T. Kobayashi, Y. Kubota, V. Lapoux, H.N. Liu, T. Motobayashi, I. Murray, H. Otsu, V. Panin, N. Paul, W. Rodriguez, H. Sakurai, M. Sasano, D. Steppenbeck, L. Stuhl, Y.L. Sun, Y. Togano, T. Uesaka, K. Wimmer, K. Yoneda, O. Aktas, T. Aumann, L.X. Chung, F. Flavigny, S. Franchoo, I. Gasparic, R.-B. Gerst, J. Gibelin, K.I. Hahn, D. Kim, T. Koiwai, Y. Kondo, P. Koseoglou, C. Lehr, B.D. Linh, T. Lokotko, M. MacCormick, K. Moschner, T. Nakamura, S.Y. Park, D. Rossi, E. Sahin, P.-A. Söderström, D. Sohler, S. Takeuchi, H. Törnqvist, V. Vaquero, V. Wagner, S. Wang, V. Werner, X. Xu, H. Yamada, D. Yan, Z. Yang, M. Yasuda, L. Zanetti

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Numerical investigation of dam break flow over erodible beds with diverse substrate level variations by Khoshkonesh Alireza, Nsom Blaise, Okhravi Saeid, Dehrashid Fariba Ahmadi, Heidarian Payam, DiFrancesco Silvia

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Wastewater-based proteomics: A proof-of-concept for advancing early warning system for infectious diseases and immune response monitoring by Kishore Kumar Jagadeesan, Harry Elliss, Richard Standerwick, Megan Robertson, Ruth Barden, Barbara Kasprzyk-Hordern

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Efficacy and safety of frontline systemic therapy for advanced HCC: A network meta-analysis of landmark phase III trials by Claudia Angela Maria Fulgenzi, Bernhard Scheiner, James Korolewicz, Charalampos-Vlasios Stikas, Alessandra Gennari, Bruno Vincenzi, Mark R. Openshaw, Marianna Silletta, Matthias Pinter, Alessio Cortellini, Lorenza Scotti, Antonio D’Alessio, David J. Pinato

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Predicting progression-free survival after systemic therapy in advanced head and neck cancer: Bayesian regression and model development by Paul R Barber, Rami Mustapha, Fabian Flores-Borja, Giovanna Alfano, Kenrick Ng, Gregory Weitsman, Luigi Dolcetti, Ali Abdulnabi Suwaidan, Felix Wong, Jose M Vicencio, Myria Galazi, James W Opzoomer, James N Arnold, Selvam Thavaraj, Shahram Kordasti, Jana Doyle, Jon Greenberg, Magnus T Dillon, Kevin J Harrington, Martin Forster, Anthony CC Coolen, Tony Ng

“…Funding: Daiichi Sankyo Inc, Cancer Research UK, EU IMI2 IMMUCAN, UK Medical Research Council, European Research Council (335326), Merck Serono. …”
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Efficacy and safety of trastuzumab deruxtecan in the treatment of HER2-low/positive advanced breast cancer: a single-arm meta-analysis by Zongyu Li, Zongyu Li, Shangwen Guo, Shangwen Guo, Haoyi Xue, Luying Li, Yuyuan Guo, Sinuo Duan, He Zhu

“…Nevertheless, there are some variations in the efficacy of trial results, with potential risks at the safety level. Most DS-8201 trials in HER2 advanced breast cancer (ABC) have been conducted in the form of small-sample nonrandomized controlled studies, resulting in a lack of validated indicators to evaluate the efficacy and safety of DS-8201. …”
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Experiences of pain and pain management in advanced disease and serious illness for people from South Asian communities in Leeds and Bradford: a qualitative interview study by Gemma Clarke, Jodie Crooks, Michael I. Bennett, Zarina Mirza, Ruby Bhatti OBE, Wali Nazar, Rahila Mughal, Shenaz Ahmed

“…However, there is limited research in South Asian communities in the UK on their experiences of pain. The aim of this study is to explore the experiences and attitudes of patients and family carers from South Asian communities about pain and its management within advanced disease or serious illness. …”
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Factors Affecting Emotional Intelligence Levels in Medical Trainees: Should All Trainees Undertake a Gap Year? [Letter] by Moussa R, Moussa E

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Causality between urate levels with sarcopenia-related traits: a bi-directional Mendelian randomization study by Yanze Lin, Yanze Lin, Xun Wang, Wenchao Yao, Yuanting Sun, Jinlei Zhou, Fabo Feng

“…Sensitivity analysis demonstrated the robustness of findings.ConclusionOur MR study revealed the absence of the bidirectional causal relationship between serum urate levels and sarcopenia. It is imperative to acknowledge that advanced age and an individual’s health status are pivotal determinants influencing urate level and the initiation and advancement of sarcopenia. …”
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Analytical Study of the Level of Attention to Some Selected Economic Components in Selected Primary School Textbooks in Iran by Morteza Afgheh, Leili Nouralizadeh, Seyyed Jalal Hashemi

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