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  1. 241
    Multiparametric MRI to quantify disease and treatment response in mice with myeloproliferative neoplasms

    Multiparametric MRI to quantify disease and treatment response in mice with myeloproliferative neoplasms by Tanner H. Robison, Manisha Solipuram, Kevin Heist, Ghoncheh Amouzandeh, Winston Y. Lee, Brock A. Humphries, Johanna M. Buschhaus, Avinash Bevoor, Anne Zhang, Kathryn E. Luker, Kristen Pettit, Moshe Talpaz, Dariya Malyarenko, Thomas L. Chenevert, Brian D. Ross, Gary D. Luker

    Published 2022-10-01
    “…American Society for Clinical investigation…”
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  2. 242
    Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment

    Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment by Silvia Squillace, Michael L. Niehoff, Timothy M. Doyle, Michael Green, Emanuela Esposito, Salvatore Cuzzocrea, Christopher K. Arnatt, Sarah Spiegel, Susan A. Farr, Daniela Salvemini

    Published 2022-09-01
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  3. 243
    Type II alveolar epithelial cell–specific loss of RhoA exacerbates allergic airway inflammation through SLC26A4

    Type II alveolar epithelial cell–specific loss of RhoA exacerbates allergic airway inflammation through SLC26A4 by Danh C. Do, Yan Zhang, Wei Tu, Xinyue Hu, Xiaojun Xiao, Jingsi Chen, Haiping Hao, Zhigang Liu, Jing Li, Shau-Ku Huang, Mei Wan, Peisong Gao

    Published 2021-07-01
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  4. 244
    Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation

    Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation by Yvonne L. Latour, Johanna C. Sierra, Jordan L. Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Thaddeus M. Smith, Kara M. McNamara, Paula B. Luis, Claus Schneider, Justin Jacobse, Jeremy A. Goettel, M. Wade Calcutt, Kristie L. Rose, Kevin L. Schey, Ginger L. Milne, Alberto G. Delgado, M. Blanca Piazuelo, Bindu D. Paul, Solomon H. Snyder, Alain P. Gobert, Keith T. Wilson

    Published 2022-06-01
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  5. 245
    Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins

    Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins by Hui-Hua Li, Monte S. Willis, Pamela Lockyer, Nathaniel Miller, Holly McDonough, David J. Glass, Cam Patterson

    Published 2022-01-01
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  6. 246
    Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity

    Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity by Thao N.D. Pham, Christina Spaulding, Mario A. Shields, Anastasia E. Metropulos, Dhavan N. Shah, Mahmoud G. Khalafalla, Daniel R. Principe, David J. Bentrem, Hidayatullah G. Munshi

    Published 2022-05-01
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  7. 247
    Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma

    Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma by Katsuyoshi Takata, Lauren C. Chong, Daisuke Ennishi, Tomohiro Aoki, Michael Yu Li, Avinash Thakur, Shannon Healy, Elena Viganò, Tao Dao, Daniel Kwon, Gerben Duns, Julie S. Nielsen, Susana Ben-Neriah, Ethan Tse, Stacy S. Hung, Merrill Boyle, Sung Soo Mun, Christopher M. Bourne, Bruce Woolcock, Adèle Telenius, Makoto Kishida, Shinya Rai, Allen W. Zhang, Ali Bashashati, Saeed Saberi, Gianluca D’Antonio, Brad H. Nelson, Sohrab P. Shah, Pamela A. Hoodless, Ari M. Melnick, Randy D. Gascoyne, Joseph M. Connors, David A. Scheinberg, Wendy Béguelin, David W. Scott, Christian Steidl

    Published 2022-05-01
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  8. 248
    Sensing of RNA stress by mTORC1 drives autoinflammation

    Sensing of RNA stress by mTORC1 drives autoinflammation by Min Ae Lee-Kirsch

    Published 2022-01-01
    “…American Society for Clinical Investigation…”
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  9. 249
    The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response

    The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response by Yi-Rong Zeng, Jun-Bin Song, Dezheng Wang, Zi-Xuan Huang, Cheng Zhang, Yi-Ping Sun, Gang Shu, Yue Xiong, Kun-Liang Guan, Dan Ye, Pu Wang

    Published 2023-03-01
    “…American Society for Clinical Investigation…”
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  10. 250
    NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

    NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22 by Marianne R. Spalinger, Stephanie Kasper, Claudia Gottier, Silvia Lang, Kirstin Atrott, Stephan R. Vavricka, Sylvie Scharl, Petrus M. Gutte, Markus G. Grütter, Hans-Dietmar Beer, Emmanuel Contassot, Andrew C. Chan, Xuezhi Dai, David J. Rawlings, Florian Mair, Burkhard Becher, Werner Falk, Michael Fried, Gerhard Rogler, Michael Scharl

    Published 2023-02-01
    “…American Society for Clinical Investigation…”
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  11. 251
    Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment

    Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment by Sydney Stern, Dongdong Liang, Linhao Li, Ritika Kurian, Caitlin Lynch, Srilatha Sakamuru, Scott Heyward, Junran Zhang, Kafayat Ajoke Kareem, Young Wook Chun, Ruili Huang, Menghang Xia, Charles C. Hong, Fengtian Xue, Hongbing Wang

    Published 2022-06-01
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  12. 252
    SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8

    SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8 by Valentina Salvi, Hoang Oanh Nguyen, Francesca Sozio, Tiziana Schioppa, Carolina Gaudenzi, Mattia Laffranchi, Patrizia Scapini, Mauro Passari, Ilaria Barbazza, Laura Tiberio, Nicola Tamassia, Cecilia Garlanda, Annalisa Del Prete, Marco A. Cassatella, Alberto Mantovani, Silvano Sozzani, Daniela Bosisio

    Published 2021-09-01
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  13. 253
    An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis

    An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis by Azadeh Reyahi, Marie Studahl, Morten K. Skouboe, Stefanie Fruhwürth, Ryo Narita, Fanghui Ren, Moa Bjerhem Viklund, Marie B. Iversen, Mette Christiansen, Alexandra Svensson, Trine H. Mogensen, Kristina Eriksson, Søren R. Paludan

    Published 2023-11-01
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  14. 254
    Fetal and maternal NLRP3 signaling is required for preterm labor and birth

    Fetal and maternal NLRP3 signaling is required for preterm labor and birth by Kenichiro Motomura, Roberto Romero, Jose Galaz, Li Tao, Valeria Garcia-Flores, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Derek Miller, Pedro Gutierrez-Contreras, Marcelo Farias-Jofre, Siddhesh Aras, Lawrence I. Grossman, Adi L. Tarca, Nardhy Gomez-Lopez

    Published 2022-08-01
    “…American Society for Clinical investigation…”
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  15. 255
    IL-18–secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models

    IL-18–secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models by Janneke E. Jaspers, Jonathan F. Khan, William D. Godfrey, Andrea V. Lopez, Metamia Ciampricotti, Charles M. Rudin, Renier J. Brentjens

    Published 2023-05-01
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  16. 256
    Linking erythropoietin to Treg-dependent allograft survival through myeloid cells

    Linking erythropoietin to Treg-dependent allograft survival through myeloid cells by Julian K. Horwitz, Sofia Bin, Robert L. Fairchild, Karen S. Keslar, Zhengzi Yi, Weijia Zhang, Vasile I. Pavlov, Yansui Li, Joren C. Madsen, Paolo Cravedi, Peter S. Heeger

    Published 2022-05-01
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  17. 257
    Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis

    Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis by Wojciech Francuzik, Kristijan Pažur, Magdalena Dalke, Sabine Dölle-Bierke, Magda Babina, Margitta Worm

    Published 2022-04-01
    “…American Society for Clinical investigation…”
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  18. 258
    Determinants of brain swelling in pediatric and adult cerebral malaria

    Determinants of brain swelling in pediatric and adult cerebral malaria by Praveen K. Sahu, Fergal J. Duffy, Selasi Dankwa, Maria Vishnyakova, Megharay Majhi, Lukas Pirpamer, Vladimir Vigdorovich, Jabamani Bage, Sameer Maharana, Wilson Mandala, Stephen J. Rogerson, Karl B. Seydel, Terrie E. Taylor, Kami Kim, D. Noah Sather, Akshaya Mohanty, Rashmi R. Mohanty, Anita Mohanty, Rajyabardhan Pattnaik, John D. Aitchison, Angelika Hoffmann, Sanjib Mohanty, Joseph D. Smith, Maria Bernabeu, Samuel C. Wassmer

    Published 2022-01-01
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  19. 259
    Combined heterozygosity of FLT3ITD, TET2, and DNMT3A results in aggressive leukemia

    Combined heterozygosity of FLT3ITD, TET2, and DNMT3A results in aggressive leukemia by Baskar Ramdas, Palam Lakshmi Reddy, Raghuveer Singh Mali, Santhosh Kumar Pasupuleti, Ji Zhang, Mark R. Kelley, Sophie Paczesny, Chi Zhang, Reuben Kapur

    Published 2022-09-01
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  20. 260
    Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

    Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets by Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K. Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L. Lyons, Jens O. Lagerstedt, Mohammad Barghouth, Jonathan L.S. Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Rashmi B. Prasad, Luis Rodrigo Cataldo, Charlotte Ling

    Published 2023-02-01
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