Quisinostat is a brain-penetrant radiosensitizer in glioblastoma by Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna-Melendez, James B. McNamara, Connor I. White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Claudia Cantoni, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, Shwetal Mehta

“…American Society for Clinical investigation…”
Get full text

Nociception and pain in humans lacking a functional TRPV1 channel by Ben Katz, Rachel Zaguri, Simon Edvardson, Channa Maayan, Orly Elpeleg, Shaya Lev, Elyad Davidson, Maximilian Peters, Shlomit Kfir-Erenfeld, Esther Berger, Shifa Ghazalin, Alexander M. Binshtok, Baruch Minke

“…American Society for Clinical Investigation…”
Get full text

Aflibercept more effectively weans patients with neovascular age-related macular degeneration off therapy compared with bevacizumab by Xuan Cao, Jaron Castillo Sanchez, Tapan P. Patel, Zhiyong Yang, Chuanyu Guo, Danyal Malik, Anuoluwapo Sopeyin, Silvia Montaner, Akrit Sodhi

“…American Society for Clinical Investigation…”
Get full text

Transplanted human cones incorporate into the retina and function in a murine cone degeneration model by Sylvia J. Gasparini, Karen Tessmer, Miriam Reh, Stephanie Wieneke, Madalena Carido, Manuela Völkner, Oliver Borsch, Anka Swiersy, Marta Zuzic, Olivier Goureau, Thomas Kurth, Volker Busskamp, Günther Zeck, Mike O. Karl, Marius Ader

“…American Society for Clinical Investigation…”
Get full text

iPSC-derived reactive astrocytes from patients with multiple sclerosis protect cocultured neurons in inflammatory conditions by Janis Kerkering, Bakhrom Muinjonov, Kamil S. Rosiewicz, Sebastian Diecke, Charlotte Biese, Juliane Schiweck, Claudia Chien, Dario Zocholl, Thomas Conrad, Friedemann Paul, Marlen Alisch, Volker Siffrin

“…American Society for Clinical Investigation…”
Get full text

Chronic pain and premature mortality in men and women, using data from UK Biobank. Reply. by Marc Parisien, Audrey V. Grant, Arjun Muralidharan, Luda Diatchenko, Jeffrey S. Mogil

“…American Society for Clinical Investigation…”
Get full text

Cardiovascular complications of COVID-19 by Farnaz Farshidfar, Navid Koleini, Hossein Ardehali

“…American Society for Clinical investigation…”
Get full text

A randomized controlled experimental medicine study of ghrelin in value-based decision making by Michal Pietrzak, Adam Yngve, J. Paul Hamilton, Robin Kämpe, Rebecca Boehme, Anna Asratian, Emelie Gauffin, Andreas Löfberg, Sarah Gustavson, Emil Persson, Andrea J. Capusan, Lorenzo Leggio, Irene Perini, Gustav Tinghög, Markus Heilig

“…American Society for Clinical Investigation…”
Get full text

An immune-based biomarker signature is associated with mortality in COVID-19 patients by Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle L. Fink, Adriana A. Almeida de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory, Kerry Dobbs, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Francesco Castelli, Camillo Rossi, Duilio Brugnoni, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angio’, Paolo Bonfanti, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Emily F. Gliniewicz, Elana Shaw, Dana E. Kahle, Andre T. Rastegar, Michael Stack, Katherine Myint-Hpu, Susan L. Levinson, Mark J. DiNubile, Daniel W. Chertow, Peter D. Burbelo, Jeffrey I. Cohen, Katherine R. Calvo, John S. Tsang, NIAID COVID-19 Consortium, Helen C. Su, John I. Gallin, Douglas B. Kuhns, Raphaela Goldbach-Mansky, Michail S. Lionakis, Luigi D. Notarangelo

“…American Society for Clinical investigation…”
Get full text

Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation by Keigo Kawashima, Masanori Isogawa, Masaya Onishi, Ian Baudi, Satoru Saito, Atsushi Nakajima, Takashi Fujita, Yasuhito Tanaka

“…American Society for Clinical investigation…”
Get full text

Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease by Chenyang Lu, Shasha Li, Pingying Qing, Qiuping Zhang, Xing Ji, Zhigang Tang, Chunyan Chen, Tong Wu, Yidan Hu, Yi Zhao, Xiaohui Zhang, Qi He, David A. Fox, Chunyu Tan, Yubin Luo, Yi Liu

“…American Society for Clinical investigation…”
Get full text

Cryptic lncRNA-encoded ORFs: A hidden source of regulatory proteins by Anindya Dutta, Hui Li, Roger Abounader

“…American Society for Clinical Investigation…”
Get full text

Computational estimates of annular diameter reveal genetic determinants of mitral valve function and disease by Mengyao Yu, Catherine Tcheandjieu, Adrien Georges, Ke Xiao, Helio Tejeda, Christian Dina, Thierry Le Tourneau, Madalina Fiterau, Renae Judy, Noah L. Tsao, Dulguun Amgalan, Chad J. Munger, Jesse M. Engreitz, Scott M. Damrauer, Nabila Bouatia-Naji, James R. Priest

“…American Society for Clinical investigation…”
Get full text

Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene by Jie Xu, Alessandra Livraghi-Butrico, Xia Hou, Carthic Rajagopalan, Jifeng Zhang, Jun Song, Hong Jiang, Hong-Guang Wei, Hui Wang, Mohamad Bouhamdan, Jinxue Ruan, Dongshan Yang, Yining Qiu, Youming Xie, Ronald Barrett, Sharon McClellan, Hongmei Mou, Qingtian Wu, Xuequn Chen, Troy D. Rogers, Kristen J. Wilkinson, Rodney C. Gilmore, Charles R. Esther Jr., Khalequz Zaman, Xiubin Liang, Michael Sobolic, Linda Hazlett, Kezhong Zhang, Raymond A. Frizzell, Martina Gentzsch, Wanda K. O’Neal, Barbara R. Grubb, Y. Eugene Chen, Richard C. Boucher, Fei Sun

“…American Society for Clinical investigation…”
Get full text

Neutrophil extracellular traps in cardiac hypertrophy: a KLF2 perspective by Dario F. Riascos-Bernal, Nicholas E.S. Sibinga

“…American Society for Clinical Investigation…”
Get full text

Connecting aging biology and inflammation in the omics era by Keenan A. Walker, Nathan Basisty, David M. Wilson III, Luigi Ferrucci

“…American Society for Clinical Investigation…”
Get full text

CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3β axis by Pallavi Mohapatra, Omprakash Shriwas, Sibasish Mohanty, Arup Ghosh, Shuchi Smita, Sandeep Rai Kaushik, Rakesh Arya, Rachna Rath, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Sunil K. Raghav, Ranjan K. Nanda, Rupesh Dash

“…American Society for Clinical investigation…”
Get full text

Amelioration of muscle and nerve pathology of Lama2-related dystrophy by AAV9-laminin-αLN linker protein by Karen K. McKee, Peter D. Yurchenco

“…American Society for Clinical investigation…”
Get full text

LRH-1 induces hepatoprotective nonessential amino acids in response to acute liver injury by Kevin C. Klatt, Elizabeth J. Petviashvili, David D. Moore

“…American Society for Clinical Investigation…”
Get full text

The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis by Carlos de la Calle-Fabregat, Javier Rodríguez-Ubreva, Laura Ciudad, Julio Ramírez, Raquel Celis, Ana Belén Azuaga, Andrea Cuervo, Eduard Graell, Carolina Pérez-García, César Díaz-Torné, Georgina Salvador, José A. Gómez-Puerta, Isabel Haro, Raimon Sanmartí, Juan D. Cañete, Esteban Ballestar

“…American Society for Clinical investigation…”
Get full text