Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function by Wild, PS, Felix, JF, Schillert, A, Teumer, A, Chen, M-H, Leening, MJG, Völker, U, Großmann, V, Brody, JA, Irvin, MR, Shah, SJ, Pramana, S, Lieb, W, Schmidt, R, Stanton, AV, Malzahn, D, Smith, AV, Sundström, J, Minelli, C, Ruggiero, D, Lyytikäinen, L-P, Tiller, D, Smith, JG, Monnereau, C, Di Tullio, MR, Musani, SK, Morrison, AC, Pers, TH, Morley, M, Kleber, ME, Aragam, J, Benjamin, EJ, Bis, JC, Bisping, E, Broeckel, U, Cheng, S, Deckers, JW, Del Greco M, F, Edelmann, F, Fornage, M, Franke, L, Friedrich, N, Harris, TB, Hofer, E, Hofman, A, Huang, J, Hughes, AD, Kähönen, M, investigators, KNHI, Kruppa, J, Lackner, KJ, Lannfelt, L, Laskowski, R, Launer, LJ, Leosdottir, M, Lin, H, Lindgren, CM, Loley, C, MacRae, CA, Mascalzoni, D, Mayet, J, Medenwald, D, Morris, AP, Müller, C, Müller-Nurasyid, M, Nappo, S, Nilsson, PM, Nuding, S, Nutile, T, Peters, A, Pfeufer, A, Pietzner, D, Pramstaller, PP, Raitakari, OT, Rice, KM, Rivadeneira, F, Rotter, JI, Ruohonen, ST, Sacco, RL, Samdarshi, TE, Schmidt, H, Sharp, ASP, Shields, DC, Sorice, R, Sotoodehnia, N, Stricker, BH, Surendran, P, Thom, S, Töglhofer, AM, Uitterlinden, AG, Wachter, R, Völzke, H, Ziegler, A, Münzel, T, März, W, Cappola, TP, Hirschhorn, JN, Mitchell, GF, Smith, NL, Fox, ER, Dueker, ND, Jaddoe, VWV, Melander, O, Russ, M, Lehtimäki, T, Ciullo, M, Hicks, AA, Lind, L, Gudnason, V, Pieske, B, Barron, AJ, Zweiker, R, Schunkert, H, Ingelsson, E, Liu, K, Arnett, DK, Psaty, BM, Blankenberg, S, Larson, MG, Felix, SB, Franco, OH, Zeller, T, Vasan, RS, Dörr, M

“…American Society for Clinical Investigation…”

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2 by Lucotti, S, Cerutti, C, Soyer, M, Gil-Bernabé, A, Gomes, A, Allen, P, Smart, S, Markelc, B, Watson, K, Armstrong, P, Mitchell, J, Warner, T, Ridley, A, Muschel, R

“…American Society for Clinical Investigation…”

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity by Ackerman, M, Crispin, M, Yu, X, Baruah, K, Boesch, A, Harvey, D, Dugast, A, Heizen, E, Ercan, A, Choi, I, Streeck, H, Nigrovic, P, Bailey-Kellogg, C, Scanlan, C, Alter, G

“…American Society for Clinical Investigation…”

Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes by Gandasi, NR, Yin, P, Riz, M, Chibalina, MV, Cortese, G, Lund, PE, Matveev, V, Rorsman, P, Sherman, A, Pedersen, MG, Barg, S

“…American Society for Clinical Investigation…”

Foxp3 drives oxidative phosphorylation and protection from lipotoxicity. by Howie, D, Cobbold, S, Adams, E, Ten Bokum, A, Necula, A, Zhang, W, Huang, H, Roberts, D, Thomas, B, Hester, S, Vaux, D, Betz, A, Waldmann, H

“…American Society for Clinical Investigation…”

Vimentin restrains regulatory T-cell suppression of graft-versus-host disease by McDonal-Hyman, C, Muller, J, Loschi, M, Thangavelu, G, Saha, A, Kumari, S, Reichenbach, D, Smith, M, Zhang, G, Loschi, M, Koehn, BH, Lin, J, Mitchell, JS, Fife, BT, Panoskaltsis-Mortari, A, Feser, C, Kirchmeier, AK, Osborn, MJ, Hippen, KL, Kelekar, A, Serody, JS, Turka, LA, Munn, DH, Chi, H, Neubert, TA, Dustin, ML, Blazar, BR, Dustin, M

“…American Society for Clinical Investigation…”

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. by Saha, A, O'Connor, R, Thangavelu, G, Lovitch, S, Dandamudi, D, Wilson, C, Vincent, B, Tkachev, V, Pawlicki, J, Furlan, S, Kean, L, Aoyama, K, Taylor, P, Panoskaltsis-Mortari, A, Foncea, R, Ranganathan, P, Devine, S, Burrill, J, Guo, L, Sacristan, C, Snyder, N, Blair, I, Milone, M, Dustin, M, Riley, J, Bernlohr, D, Murphy, W, Fife, B, Munn, D, Miller, J, Serody, J, Freeman, G, Sharpe, A, Turka, L, Blazar, B

“…American Society for Clinical Investigation…”

Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy by Willoughby, CE, Jiang, Y, Thomas, HD, Willmore, E, Kyle, S, Wittner, A, Phillips, N, Zhao, Y, Tudhope, SJ, Prendergast, L, Junge, G, Lourenco, LM, Finlay, MRV, Turner, P, Munck, JM, Griffin, RJ, Rennison, T, Pickles, J, Cano, C, Newell, DR, Reeves, HL, Ryan, AJ, Wedge, SR

“…American Society for Clinical Investigation…”

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload by Schwartz, A, Das, N, Ramakrishnan, S, Jain, C, Jurkovic, M, Wu, J, Nemeth, E, Lakhal-Littleton, S, Colacino, J, Shah, Y

“…American Society for Clinical Investigation…”

Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation by Chen, J, Cao, Y, Markelc, B, Kaeppler, J, Vermeer, JAF, Muschel, RJ

“…American Society for Clinical Investigation…”

Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity by Chung, Y, Antao, L, Park, K, Loonat, A, Lakhal-Littleton, S, Robbins, P, Swietach, P

“…American Society for Clinical Investigation…”

Heterologous prime-boost vaccination protects against EBV antigen-expressing lymphomas. by Rühl, J, Citterio, C, Engelmann, C, Haigh, T, Dzionek, A, Dreyer, J, Khanna, R, Taylor, G, Wilson, J, Leung, C, Münz, C

“…American Society for Clinical Investigation…”

Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling by Munshaw, S, Bruche, S, Redpath, A, Jones, A, Patel, J, Dube, K, Lee, R, Hester, S, Davies, R, Neal, G, Handa, A, Sattler, M, Fischer, R, Channon, K, Smart, N

“…American Society for Clinical Investigation…”

Molecular correlates of vaccine-induced protection against typhoid fever by Zhu, H, Chelysheva, I, Cross, DL, Blackwell, L, Jin, C, Gibani, MM, Jones, E, Hill, J, Trück, J, Kelly, DF, Blohmke, C, Pollard, AJ, O'Connor, D

“…American Society for Clinical Investigation…”

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals by Lee, L, Ha, D, Simmons, C, Jong, D, Chau, N, Schumacher, R, Peng, Y, McMichael, A, Farrar, J, Smith, G, Townsend, A, Askonas, B, Rowland-Jones, S, Dong, T

“…American Society for Clinical Investigation…”

Safety and PCR monitoring in 161 semi-immune Kenyan adults following controlled human malaria infection by Kapulu, MC, Njuguna, P, Hamaluba, M, Kimani, D, Ngoi, JM, Musembi, J, Ngoto, O, Otieno, E, Billingsley, PF

“…American Society for Clinical Investigation…”

Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness by Ando, T, Tai-Nagara, I, Sugiura, Y, Kusumoto, D, Okabayashi, K, Kido, Y, Sato, K, Saya, H, Navankasattusas, S, Li, DY, Suematsu, M, Kitagawa, Y, Seiradake, E, Yamagishi, S, Kubota, Y

“…American Society for Clinical Investigation…”

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction. by Meakin, PJ, Coull, BM, Tuharska, Z, McCaffery, C, Akoumianakis, I, Antoniades, C, Brown, J, Griffin, KJ, Platt, F, Ozber, CH, Yuldasheva, NY, Makava, N, Skromna, A, Prescott, AR, McNeilly, AD, Siddiqui, MK, Palmer, CNA, Khan, F, Ashford, MLJ

“…American Society for Clinical Investigation…”

Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis by Song, J, Schwenzer, A, Midwood, KIM

“…American Society for Clinical Investigation…”

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control by Cheng, X, Prange-Barczynska, M, Fielding, J, Zhang, M, Burrell, A, Lima, J, Eckardt, L, Argles, I, Pugh, C, Buckler, K, Robbins, P, Hodson, E, Bruick, R, Collinson, L, Rastinejad, F, Bishop, T, Ratcliffe, P

“…American Society for Clinical Investigation…”