Extracts from The Cochrane Library: Antibiotics for acute maxillary sinusitis. অনুযায়ী Burton, M, Kuppersmith, R, Rosenfeld, R

“…This installment features a Cochrane Review entitled "Antibiotics for acute maxillary sinusitis," which concludes a small treatment effect in patients with uncomplicated acute sinusitis in a primary care setting with symptoms for more than seven days.…”

Minimizing treatment-induced emergence of antibiotic resistance in bacterial infections অনুযায়ী Stracy, M, Snitser, O, Yelin, I, Amer, Y, Parizade, M, Katz, R, Rimler, G, Wolf, T, Herzel, E, Koren, G, Kuint, J, Foxman, B, Chodick, G, Shalev, V, Kishony, R

“…Treatment of bacterial infections currently focuses on choosing an antibiotic that matches a pathogen’s susceptibility, with less attention paid to the risk that even susceptibility-matched treatments can fail as a result of resistance emerging in response to treatment. …”

Oligomerisation of pneumolysin on cholesterol crystals: similarities to the behaviour of polyene antibiotics. অনুযায়ী Sonnen, A, Rowe, A, Andrew, P, Gilbert, R

“…Here we provide further insights into the pneumolysin oligomer by studying the interaction of pneumolysin with cholesterol crystals, comparing the results to those obtained for polyene antibiotics, which also bind cholesterol.…”

Toxin import through the antibiotic efflux channel TolC অনুযায়ী Housden, NG, Webby, MN, Lowe, ED, El-Baba, TJ, Kaminska, R, Robinson, CV, Kleanthous, C, Redfield, C

“…Our results indicate that TolC, in addition to its known role in antibiotic export, can function as a protein import channel for bacteriocins.…”

Taxing meat: Taking responsibility for one's contribution to antibiotic resistance অনুযায়ী Giubilini, A, Birkl, P, Douglas, T, Savulescu, J, Maslen, H

“…Antibiotic use in animal farming is one of the main drivers of antibiotic resistance both in animals and in humans. …”

Contemporary outcomes of debridement, antibiotics and implant retention in knee arthroplasty অনুযায়ী Middleton, R, Price, A, Alvand, A

“…Surgical options include debridement, antibiotics and implant retention (DAIR), single-stage revision, two-stage revision and salvage procedures. …”

Explaining variation in antibiotic prescribing between general practices in the UK অনুযায়ী Pouwels, K, Dolk, F, Smith, D, Smieszek, T, Robotham, J

“…Objectives:Primary care practices in England differ in antibiotic prescribing rates, and, anecdotally, prescribers justify high prescribing rates based on their individual case mix. …”

Molecular biology of antibiotic resistance elements in human haemophilus SPP অনুযায়ী Zain, Z

“…<p>Antibiotic resistance in <em>Haemophilus influenzae</em> emerged in the 1970s and rapidly rose in prevalence worldwide. …”

Antibiotic duration for common bacterial infections—a systematic review অনুযায়ী Mo, Y, Tan, WC, Cooper, BS

“…Background: Reducing antibiotic duration is a key stewardship intervention to mitigate antimicrobial resistance (AMR). …”

Oligomerisation of pneumolysin on cholesterol crystals: Similarities to the behaviour of polyene antibiotics অনুযায়ী Sonnen, A, Rowe, A, Andrew, P, Gilbert, R

The social evolutionary dynamics of antibiotic resistance in Pseudomonas aeruginosa infections অনুযায়ী Crosse, DJM

“…One such potential public good is the resistance enzyme beta-lactamase, which degrades beta-lactam antibiotics. Public good producers are vulnerable to exploitation by non-producing cheats, which in this case would be antibiotic-sensitive cells. …”

Optimising trial designs to identify appropriate antibiotic treatment durations অনুযায়ী Pouwels, K, Yin, M, Butler, C, Cooper, B, Wordsworth, S, Walker, A, Robotham, J

“…<p><strong>Background</strong></p> <p>For many infectious conditions, the optimal antibiotic course length remains unclear. The estimation of course length must consider the important trade-off between maximising short- and long-term efficacy and minimising antibiotic resistance and toxicity.…”

Investigation of prevalence of MRSA in referrals to neurosurgery: implications for antibiotic prophylaxis. অনুযায়ী Hammond, C, Gill, J, Peto, T, Cadoux-Hudson, T, Bowler, I

“…In order to establish the appropriateness of our current prophylactic antibiotic regimen we analysed the prevalence of MRSA in emergency referrals to our unit. …”

Antibiotic management and early discharge from hospital: an economic analysis. অনুযায়ী Gray, A, Dryden, M, Charos, A

“… OBJECTIVES: To evaluate potential costs and savings from implementing an evaluation tool that uses bedside review of antibiotic use and infection management to assess whether patients with infections in acute medical and surgical wards could have their antibiotic regimen changed and be safely managed out of hospital. …”

Antibiotics versus topical antiseptics for chronic suppurative otitis media অনুযায়ী Head, K, Chong, L-Y, Bhutta, MF, Morris, PS, Vijayasekaran, S, Burton, MJ, Schilder, AGM, Brennan-Jones, CG

“…</p> <p>Two comparisons were topical antiseptics compared to: a) topical antibiotics or b) systemic antibiotics. Within each comparison we separated where both groups of patients had received topical antibiotic a) alone or with aural toilet and b) on top of background treatment (such as systemic antibiotics).…”

Topical versus systemic antibiotics for chronic suppurative otitis media অনুযায়ী Chong, L, Head, K, Richmond, P, Snelling, T, Schilder, A, Burton, M, Brennan-Jones, C

“…The objectives are as follows: To assess the relative effectiveness of topical versus systemic antibiotics for people with chronic suppurative otitis media (CSOM).…”

Antibiotic use in poultry: a survey of eight farms in Thailand অনুযায়ী Wongsuvan, G, Wuthiekanun, V, Hinjoy, S, Day, N, Limmathurotsakul, D

“…To investigate antibiotic use in poultry farms in Thailand and estimate the total amount of antibiotics used annually in Thai production of chicken meat.In a single province, we surveyed eight farms in which chickens were raised for meat and interviewed the farms' owners in 2016. …”

Engineering carboxymethylproline synthases towards the biosynthetic productions of carbapenem antibiotics অনুযায়ী Gómez Castellanos, J

Addition of macrolide antibiotics for hospital treatment of community-acquired pneumonia অনুযায়ী Wei, J, Walker, S, Eyre, D

“…<p><strong>Background:</strong> Current guidelines recommend combining a macrolide with a β-lactam antibiotic for the empirical treatment of moderate-to-high severity community-acquired pneumonia (CAP); however macrolide use is associated with potential adverse events and antimicrobial resistance.…”

Association of long term antibiotic use and diagnosis of chronic disease অনুযায়ী Wachtel, S, Hoang, U, Sherlock, J, McGee, C, Byford, R, De Lusignan, S

“…<p><strong>Background:</strong> There has recently been increasing interest in the role of the human microbiome in disease. Antibiotic use is known to disrupt the intestinal microbial environment and cause acute disease, for example pseudomembranous colitis. …”