Dual predation by bacteriophage and Bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot by Hobley, L, Summers, JK, Till, R, Milner, DS, Atterbury, RJ, Stroud, A, Capeness, MJ, Gray, S, Leidenroth, A, Lambert, C, Connerton, I, Twycross, J, Baker, M, Tyson, J, Kreft, JU, Sockett, RE

“…This suggests that combinatorial predator therapy could overcome problems of phage resistance.IMPORTANCE With increasing levels of antibiotic resistance, the development of alternative antibacterial therapies is urgently needed. …”

Intravenous doxycycline, azithromycin, or both for severe scrub typhus by Varghese, GM, Dayanand, D, Gunasekaran, K, Kundu, D, Wyawahare, M, Sharma, N, Chaudhry, D, Mahajan, SK, Saravu, K, Aruldhas, BW, Mathew, BS, Nair, RG, Newbigging, N, Mathew, A, Abhilash, KPP, Biswal, M, Prasad, AH, Zachariah, A, Iyadurai, R, Hansdak, SG, Sathyendra, S, Sudarsanam, TD, Prakash, JAJ, Manesh, A, Mohan, A, Tarning, J, Blacksell, SD, Peerawaranun, P, Waithira, N, Mukaka, M, Cheah, PY, Peter, JV, Abraham, OC, Day, NPJ

“…<p><strong>BACKGROUND:</strong> The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear.…”

Studies on the Bacterial Potassium efflux system Kef in Shewanella denitrificans SdKef by Grayer, S

“…<p>The glutathione-gated potassium efflux system (Kef) is a K⁺/H⁺ antiporter found in the majority of Gram negative pathogens, which shows potential as a novel antibiotic target. Kef plays a vital role in the protection of bacteria against toxic electrophiles through the regulation of cytoplasmic pH. …”

Cost-effectiveness of screening, decolonisation and isolation strategies for carbapenem-resistant Enterobacterales and methicillin-resistant Staphylococcus aureus infections in hos... by Allel, K, Garcia, P, Peters, A, Munita, J, Undurraga, EA, Yakob, L

“…Evidence for sex differences among antibiotic resistant bacterial infections is increasing but a focus on policy implications is needed. …”

Characterization and genomic analysis of the lytic bacteriophage vB_EclM_HK6 as a potential approach to biocontrol the spread of Enterobacter cloacae contaminating food by Temsaah, HR, Azmy, AF, Ahmed, AE, Elshebrawy, HA, Kasem, NG, El-Gohary, FA, Lood, C, Lavigne, R, Abdelkader, K

“…Background: Increased prevalence of Enterobacter cloacae within food products underscores food as an underexplored reservoir for antibiotic resistance, thus requiring particular intervention. …”

Whole-genome sequencing to determine transmission of Neisseria gonorrhoeae: an observational study by De Silva, D, Peters, J, Cole, K, Cole, M, Cresswell, F, Dean, G, Dave, J, Thomas, D, Foster, K, Waldram, A, Wilson, D, Didelot, X, Grad, Y, Crook, D, Peto, T, Walker, A, Paul, J, Eyre, D

“…New approaches are urgently required to address increasing rates of gonorrhoea and the emergence and global spread of antibiotic-resistant Neisseria gonorrhoeae. We used whole-genome sequencing to study transmission and track resistance in N gonorrhoeae isolates.We did whole-genome sequencing of isolates obtained from samples collected from patients attending sexual health services in Brighton, UK, between Jan 1, 2011, and March 9, 2015. …”

Distinguishing bacterial versus non-bacterial causes of febrile illness - A systematic review of host biomarkers by Leticia Fernandez-Carballo, B, Escadafal, C, MacLean, E, Kapasi, AJ, Dittrich, S

“…A simple tool for distinguishing bacterial versus non-bacterial infections would radically improve patient management and reduce indiscriminate antibiotic use. Diagnostic tests based on host biomarkers can play an important role here, and a target product profile (TPP) was developed to guide development. …”

Population-level faecal metagenomic profiling as a tool to predict antimicrobial resistance in Enterobacterales isolates causing invasive infections: An exploratory study across Ca... by Auguet, OT, Niehus, R, Gweon, HS, Berkley, JA, Waichungo, J, Njim, T, Edgeworth, JD, Batra, R, Chau, K, Swann, J, Walker, SA, Peto, TEA, Crook, DW, Lamble, S, Turner, P, Cooper, BS, Stoesser, N

“…Capacity for individual-level surveillance remains limited in many countries, whilst population-level surveillance approaches could inform empiric antibiotic treatment guidelines. Methods In this exploratory study, a novel approach to population-level prediction of AMR in Enterobacterales clinical isolates using metagenomic (Illumina) profiling of pooled DNA extracts from human faecal samples was developed and tested. …”

Barriers and enablers to blood culture sampling in Indonesia, Thailand and Viet Nam: a Theoretical Domains Framework-based survey by Suntornsut, P, Asadinia, KS, Limato, R, Tamara, A, Rotty, LWA, Bramanti, R, Nusantara, DU, Nelwan, EJ, Khusuwan, S, Suphamongkholchaikul, W, Chamnan, P, Piyaphanee, W, Vu, HTL, Nguyen, YH, Nguyen, KH, Pham, TN, Le, QM, Vu, VH, Chau, DM, Vo, DETH, Harriss, EK, van Doorn, HR, Hamers, RL, Lorencatto, F, Atkins, L, Limmathurotsakul, D

“…<p><strong>Objective</strong> Blood culture (BC) sampling is recommended for all suspected sepsis patients prior to antibiotic administration. We examine barriers and enablers to BC sampling in three Southeast Asian countries.…”

Individual and collective behaviour of bacteria under oxidative stress by Choudhary, D

“…Bacteria frequently experience oxidative stress during aerobic growth, host immune attack, microbiome interactions, and under antibiotic treatment. Here, we study bacteria under hydrogen peroxide (H2O2) and observe that individual cells exhibit variability in their oxidative stress response. …”

Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease – associations with disease phenotype, treatment, and outcome by Olbjørn, C, Småstuen, MC, Thiis-Evensen, E, Nakstad, B, Vatn, MH, Jahnsen, J, Ricanek, P, Vatn, S, Moen, AEF, Tannæs, TM, Lindstrøm, JC, Söderholm, JD, Halfvarson, J, Gomollón, F, Casén, C, Karlsson, MK, Kalla, R, Adams, AT, Satsangi, J, Perminow, G

“…Low Faecalibacterium prausnitzii abundance was associated with prior antibiotic therapy (P=0.001), surgery (P=0.02), and nonmucosal healing (P&lt;0.03). …”

Effect of local medicinal herbs as feed additives on production performance and faecal parameters in laying hens by Ooi, P. S., Rohaida, A. R., Nur Hardy Abu Daud, Devina David, Borhan A. R., Kartini S., Jupikely James Silip, Abdul Rahman Mohammad, Alimon, A.R.

“…To concord with the banning of antibiotic growth promoters in animal nutrition, research was carried out to utilize phytogenic feed additives in poultry nutrition as the alternative to improve their overall performance. …”
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Antibacterial effect of postbiotics from gut bacteria of whiteleg shrimp litopeaneus vannamei against aquaculture bacterial pathogens by Ang, Chun Yao

“…Various disease control strategies such as specific pathogen free postlarvae, tighter disease and effluent management, phage therapy, antibiotic, vaccination, passive immunization, phytobiotic, probiotic, prebiotic, synbiotic and parabiotic have been introduced but each has its own shortcomings. …”
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Effects of phage cocktail, probiotics and their combinations on growth performance and gut microbiota of broiler chickens by Shaufi, Mohd Asrore Mohd, Sieo, Chin Chin, Chong, Chun Wie, Geok Hun, Tan, Omar, Abdul Rahman, Han Ming, Gan, Wan Ho, Yin

“…Phages, which are often used therapeutically, have begun to receive interest as alternatives to antibiotic growth promoters (AGPs) for enhancing chicken growth. …”
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Innovative nanodelivery systems transform tuberculosis treatment with Pyrazinamide-loaded Chitosan nanoparticles by Kia, Pooneh, Hussein, Mohd Zobir, Ruman, Umme, Pratiwi, Ariyati Retno, Saad, Norazalina, Izadi, Zahra, Shameli, Kamyar

“…This study focalizes on the synthesis of chitosan nanoparticles (CSNP) as a nanocarrier for the concurrent delivery of Pyrazinamide (PYR), a pivotal antibiotic in the first-line treatment of TB. The primary objective is to overcome challenges related to the limited solubility and bioavailability of these drugs, which hinder their effectiveness and pose toxicity risks. …”
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Characterization and antimicrobial activities of two Streptomyces isolates from soil in the periphery of Universiti Putra Malaysia. by Mohamad Zin, Nurul Zarith, Tasrip, Nor Asmara, Mohd Desa, Mohd Nasir, Cheah, Yoke Kqueen, Zakaria, Zainul Amiruddin, Awang Hamat, Rukman, Shamsudin, Mariana Nor

“…The observed variation in cultural traits and growth yield indicate unique properties between the two antibiotic-producing isolates.…”
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Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody. by Ab Latif, Nurzila

“…Cells were cultured in both basal medium supplemented with different concentration of fetal bovine serum (FBS) (1, 3, 5, 7, 10 (v/v)), 4mM of L-glutamine and 10 μg/ml of antibiotic. The cell concentration and viability of the NS0 cells were determined using tryphan blue exclusion method and ELISA was used to determine the mAb titers of the cultures. …”
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Influence of postbiotic RG14 and inulin combination on cecal microbiota, organic acid concentration, and cytokine expression in broiler chickens by Kareem, Karwan Yaseen, Loh, Teck Chwen, Foo, Hooi Ling, Samsudin, Anjas Asmara @ Ab Hadi, Akit, Henny

“…Postbiotic and inulin combinations are potential replacements for antibiotic growth promoters in the poultry industry.…”
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Genotypic and phenotypic characterization of methicillin resistance determinants and β-lactamase in Staphylococcus species by Abdul Rachman, Abdul Rahim, Mat Azis, Norhidayah, Pung, Hui Ping, Suhaili, Zarizal, Amin Nordin, Syafinaz, Othman, Zulkefley, Mohd Desa, Mohd Nasir

“…Sixteen MRSA and nineteen MRCoNS were identified by biochemical tests followed by 30 µg cefoxitin antibiotic disc susceptibility test and mecA gene screening. …”
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Antibacterial Activity of Seaweed Extract and its Effects on the DNA Sequence of Selected Essential Genes of Staphylococcus Aureus by Mashan, Nurmas Idayu

“…One of the common causes contributing to the death is the increasing number of antibiotic resistance pathogens including Methicillin Resistant Staphylococcus aureus (MRSA), Extended Spectrum Beta Lactamase (ESBL) organisms, and Multiple Drug Resistant Organism (MDRO). …”
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