Rationale and protocol of the LAQUA-HF trial: a factorial randomised controlled trial evaluating the effects of neurohormonal and diuretic agents on health-status reported outcomes... by Yohei Numasawa, Ikuko Ueda, Shun Kohsaka, Yasuyuki Shiraishi, Takashi Kohno, Toshikazu Tanaka, Nobuhiro Ikemura, Makoto Takei, Mitsuyoshi Urashima, Shintaro Nakano, Yuji Nagatomo, Takenori Ikoma, Tomohiko Ono, Munehisa Sakamoto, Kei Nishikawa, Daihiko Hakuno, Ryo Nakamaru

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Serum N-terminal pro-B-type natriuretic peptide and cystatin C for acute kidney injury detection in critically ill adults in China: a prospective, observational study by Jia Deng, Ying Li, Jing Xu, Linling He, Yufan Liang, Linhui Hu, Heng Fang, Chunbo Chen

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579-A Targeting the NANOG-CRY1 axis sensitizes immunotherapy-refractory tumors and enhances efficacy of T cell-based immunotherapy by reinvigorating the anti-tumor immunity cycle by Tae Woo Kim, Min Kyu Son, Se Jin Oh

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Interventions to prevent hypothermia in extremely preterm low-weight infants undergoing cardiac catheterisation by Daisuke Kobayashi, Eliane Alhalabi, Maria Zestos, George M Mckelvey, Rachel A Taylor

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Mental health support to staff in a major hospital in Milan (Italy) during the COVID-19 pandemic: a framework of actions by Giovambattista Presti, Barbara Dal Lago, Alice Fattori, Giuliana Mioli, Paolo Moderato, Lucia Sciaretta, Maria Antonella Costantino

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Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis by Ahmed Nasr, Manvinder Kaur, Viviane Grandpierre, Irina Oltean, Vid Bijelić, Lamia Hayawi, Victoria Larocca, Emily Beveridge, Jane Kanyinda

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Predictive models for musculoskeletal injury risk: why statistical approach makes all the difference by Gary S Collins, Deydre S Teyhen, Daniel I Rhon, Garrett S Bullock

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Depression, violence and socioeconomic outcomes among refugees in East Africa: evidence from a multicountry representative survey by Julia R Pozuelo, Raphael Bradenbrink, Maria Flinder Stierna, Olivier Sterck

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Systematic review of the effectiveness of non-pharmacological interventions used to treat adults with inducible laryngeal obstruction by Janelle Yorke, Stephen J Fowler, Jemma Haines, Jenny King, Jacklyn Ann Smith, James Wingfield-Digby

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P71 Treatment patterns, healthcare resource utilization and related costs of patients with discoid lupus erythematosus (DLE) or subacute cutaneous lupus erythematosus (SCLE) in the... by Ying Sun, Benjamin F Chong, Caroline Foch, Sanjeev Roy, Dominika Weinelt, Sabrina de Souza, Xiaoxue Chen, Jeffrey M Muir

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Cardiac magnetic resonance systematically overestimates mitral regurgitations by the indirect method by Jesper Hastrup Svendsen, Morten Salling Olesen, Litten Bertelsen, Niels Vejlstrup, Laura Andreasen

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The impact of drug error reduction software on preventing harmful adverse drug events in England: a retrospective database study by Adam Sutherland, Michelle Randall, Emma Weston, William S Gerrard, Arif Patel

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Multicomponent processes to identify and prioritise low-value care in hospital settings: a scoping review by Sameera Senanayake, Zephanie Tyack, Michelle Allen, Steven M McPhail, Bridget Abell, Hannah Carter, Kym Warhurst, Sundresan Naicker

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Study protocol for the Multiple Symptoms Study 3: a pragmatic, randomised controlled trial of a clinic for patients with persistent (medically unexplained) physical symptoms by Tom Sanders, Waquas Waheed, Monica Greco, Cara Mooney, Christopher D Burton, Gillian Rowlands, Steve Thomas, Jeremy Dawson, Vincent Deary, Ruth E Thomas, David Alexander White, Kate Fryer, Michelle Horspool, Aileen Neilson

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281 Development of syngeneic mouse models to study the therapeutic efficacy of chimeric antigen receptor T cells against solid tumors by Gordon Moody, Letizia Giardino, Allison Barrett, Ping-Hsien Lee, Shannon Breen, Ashley Merlino, Lorenzo Ortiz, Rosa Carrasco

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Study protocol of REpeat versus SIngle ShoT Antibiotic prophylaxis in major Abdominal Surgery (RESISTAAS I): a prospective observational study of antibiotic prophylaxis practice fo... by Pascal Probst, Katrin Hoffmann, Markus A Weigand, Adrian Billeter, Rosa Klotz, Jan Larmann, Anastasia Murtha-Lemekhova, Juri Fuchs, Miriam Teroerde, Heike Rau, Otto R Frey, Daniel Hornuss, Ute Chiriac

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Emergency department and urgent care clinician perspectives on digital access to past medical histories by Enrico Coiera, David Lyell, Thomas Campbell Bowden

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199 Quantitative and spatial characteristics of TIL in inflammatory neighborhoods of advanced melanoma tumors by Adi Diab, Suhendan Ekmekcioglu, Noha Abdel-Wahab, Michael A Davies, Julie M Simon, Alexander J Lazar, Jared K Burks, Salah-Eddine Bentebibel, Sungnam Cho, Javier A Gomez, Reham Abdel-Wahab, Jeffrey E Gershenwald

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Public health emergency archetypes: a framework to guide efforts to ensure equitable access to medical countermeasures by Paul A Wilson, Ian Thornton, Gian Gandhi

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Excess mortality during the COVID-19 pandemic in low-income and lower middle-income countries: protocol for a systematic review and meta-analysis by John Amuasi, Wilm Quentin, Jonathan Mawutor Gmanyami, Andrzej Jarynowski, Vitaly Belik, Oscar Lambert

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