Bacterial cellulose production, functionalization, and development of hybrid materials using synthetic biology by Vadanan, Sundaravadanam Vishnu, Basu, Anindya, Lim, Sierin

“…Finally, we consider the opportunities and future prospects of synthetic biology in bioengineered materials.…”
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What's in a loop? by Feller, S, Lewitzky, M

“…It is also expected to provide critical information for synthetic biologists and bioengineers.…”

Mechanistic modelling to determine the limits of clinical and pre-clinical cancer immunotherapies by Brown, L

“…This could explain why pre-clinical success of bioengineered T-cells in solid tumours has not translated to the clinic as it has for haematological cancers. …”

Molecular dynamics approach in designing Thermostable Bacillus circulans Xylanase by Noorbatcha, Ibrahim Ali, Mohd. Salleh, Hamzah

“…As RMSD represents structural fluctuation at a particular temperature, a better understanding of this factor will suggest approaches to bioengineer these enzymes to enhance their thermostability. …”
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Can We Build Artificial Stem Cell Compartments? by Semino, Carlos E.

“…The main factors required to regulate the maintenance and differentiation of some types of stem cells are known. In addition, new bioengineered synthetic materials that mimic extracellular matrix components can be used as initial scaffolding for building stem cell microenvironments.…”
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Toward stable gene expression in CHO cells Preventing promoter silencing with core CpG island elements by Mariati, Koh, Esther YC, Yeo, Jessna HM, Ho, Steven CL, Yang, Yuansheng

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Photosynthetic electron partitioning between [FeFe]-hydrogenase and ferredoxin:NADP+-oxidoreductase (FNR) enzymes in vitro by Yacoby, Iftach, Pochekailov, Sergii, Zhang, Shuguang, Toporik, Hila, Ghirardi, Maria L., King, Paul W.

“…To elucidate the basis for competition, we bioengineered a ferredoxin-hydrogenase fusion and characterized hydrogen production kinetics in the presence of Fd, ferredoxin:NADP+-oxidoreductase (FNR), and NADP+. …”
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Study of two G-protein coupled receptor variants of human trace amine-associated receptor 5 by Wang, Xiaoqiang, Corin, Karolina A., Rich, Cyrus, Zhang, Shuguang

“…Here we report the study of two bioengineered variants of human trace amine-associated receptor 5 (hTAAR5) that were expressed in stable tetracycline-inducible HEK293S cell lines. …”
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Engineering scalable biological systems by Lu, Timothy K.

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Continuous-Flow Bioseparation Using Microfabricated Anisotropic Nanofluidic Sieving Structures by Fu, Jianping, Mao, Pan, Han, Jongyoon

“…This protocol is most useful for bioengineers who are interested in developing automated multistep chip-based bioanalysis systems and assumes previous cleanroom microfabrication knowledge. …”
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Biomolecular control over local gating in bilayer graphene induced by ferritin by Karuppannan, Senthil Kumar, Martin, Jens, Xu, Wentao, Pasula, Rupali Reddy, Lim, Sierin, Nijhuis, Christian A.

“…We demonstrate local gating of BLG in the nanometer range by adsorption of AfFtnAA (which is a bioengineered ferritin, an iron-storing globular protein with ∅ = 12 nm). …”
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A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease by Cairns, Dana M, Rouleau, Nicolas, Parker, Rachael N, Walsh, Katherine G, Gehrke, Lee, Kaplan, David L

“…Here, we describe a multidisciplinary approach to produce physiologically relevant human tissues to study AD using human-induced neural stem cells (hiNSCs) and HSV-1 infection in a 3D bioengineered brain model. We report a herpes-induced tissue model of AD that mimics human disease with multicellular amyloid plaque–like formations, gliosis, neuroinflammation, and decreased functionality, completely in the absence of any exogenous mediators of AD. …”
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A single-cell liver atlas of Plasmodium vivax infection by Mancio-Silva, Liliana, Gural, Nil, Real, Eliana, Wadsworth, Marc H, Butty, Vincent L, March, Sandra, Nerurkar, Niketa, Hughes, Travis K, Roobsoong, Wanlapa, Fleming, Heather E, Whittaker, Charlie A, Levine, Stuart S, Sattabongkot, Jetsumon, Shalek, Alex K, Bhatia, Sangeeta N

“…Here, we leverage a bioengineered human microliver platform to culture patient-derived P. vivax parasites for transcriptional profiling. …”
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Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo by Camacho, Noelia, Tor, Anna, Wilkinson, Barrie, Moss, Steven, Mirando, Adam C., Francklyn, Christopher S., Royo, Miriam, Novoa Pardo, Eva Maria, Marin-Garcia, Patricia, Axcarate, Isabel G., Bautista, Jose M., Varon, Sonia, Cortes, Alfred, Ribas de Pouplana, Lluis

“…To circumvent this problem, we tested a library of bioengineered and semisynthetic borrelidin analogs for their antimalarial activity and toxicity. …”
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Regenerative medicine as applied to solid organ transplantation: current status and future challenges. by Orlando, G, Baptista, P, Birchall, M, De Coppi, P, Farney, A, Guimaraes-Souza, N, Opara, E, Rogers, J, Seliktar, D, Shapira-Schweitzer, K, Stratta, R, Atala, A, Wood, K, Soker, S

“…Creation of custom-made bioengineered organs, where the cellular component is exquisitely autologous and have an internal vascular network, will theoretically overcome the two major hurdles in transplantation, namely the shortage of organs and the toxicity deriving from lifelong immunosuppression. …”

Biomanufacturing process for the production of bacteriocins from Bacillaceae family by Lajis, Ahmad Firdaus

“…It also highlights recent advance in the production of bioengineered and recombinant bacteriocins in bioreactors system which are rarely disclosed in literature.…”
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Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers by Mancio Silva, Liliana, Fleming, Heather, Miller, Alex B, Milstein, Stuart, Liebow, Abigail, Haslett, Patrick, Sepp-Lorenzino, Laura, Bhatia, Sangeeta N

“…Here, we apply a new modality to a previously established, functionally stable, multi-well bioengineered microliver—fabricated from primary human hepatocytes and supportive stromal cells—in order to advance both small molecule and nucleic acid therapeutic pipelines. …”
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Synthetic biomarkers: a twenty-first century path to early cancer detection by Kwong, Gabriel A, Ghosh, Sharmistha, Gamboa, Lena, Patriotis, Christos, Srivastava, Sudhir, Bhatia, Sangeeta N

“…These represent an emerging class of diagnostics that deploy bioengineered sensors inside the body to query early-stage tumours and amplify disease signals to levels that could potentially exceed those of shed biomarkers. …”
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Synthetic biomarkers: a twenty-first century path to early cancer detection by Kwong, Gabriel A., Ghosh, Sharmistha, Gamboa, Lena, Patriotis, Christos, Srivastava, Sudhir, Bhatia, Sangeeta N.

“…These represent an emerging class of diagnostics that deploy bioengineered sensors inside the body to query early-stage tumours and amplify disease signals to levels that could potentially exceed those of shed biomarkers. …”
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High relaxivity biomolecule based contrast agents engineered for molecular functional magnetic resonance imaging by Hsieh, Vivian, Ph. D. Massachusetts Institute of Technology

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