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2381
Molecular imaging of bacterial outer membrane vesicles based on bacterial surface display
Published 2024“…This novel method can serve as a basis for a general OMV radiolabeling scheme and could be used in vaccine- and drug-carrier development based on bioengineered OMVs.…”
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Journal Article -
2382
A comparative evaluation of the effect of polymer chemistry and fiber orientation on mesenchymal stem cell differentiation.
Published 2016“…Bioengineered tissue scaffolds in combination with cells hold great promise for tissue regeneration. …”
Journal article -
2383
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2384
Switching of the mechanism of charge transport induced by phase transitions in tunnel junctions with large biomolecular cages
Published 2022“…This paper describes a temperature-induced change in the CT mechanism across junctions with large globular (similar to 25 nm in diameter) E2-proteins bioengineered with Fe-binding peptides from ferritin (E2-LFtn) to mineralise Fe ions in the form of iron oxide nanoparticles (NPs) inside the protein's cavity. …”
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Journal Article -
2385
Computational physiology and the Physiome Project.
Published 2004“…Bioengineering analyses of physiological systems use the computational solution of physical conservation laws on anatomically detailed geometric models to understand the physiological function of intact organs in terms of the properties and behaviour of the cells and tissues within the organ. …”
Journal article -
2386
Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach.
Published 2013“…The objectives of this study were to apply bioengineered three-dimensional (3D) microenvironments for culturing ovarian cancer spheroids in vitro and simultaneously to build on a mathematical model describing the growth of multicellular spheroids in these biomimetic matrices. …”
Journal article -
2387
Computational physiology and the Physiome Project
Published 2004“…Bioengineering analyses of physiological systems use the computational solution of physical conservation laws on anatomically detailed geometric models to understand the physiological function of intact organs in terms of the properties and behaviour of the cells and tissues within the organ. …”
Journal article -
2388
On the flow behavior of confined vortex-rings
Published 2021“…Overall, the results of the current project have important implications on the design of stents and valves for bioengineers as well as for those investigating flow in constricted arteries and aneurisms.…”
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Final Year Project (FYP) -
2389
Regenerative capacity of the corneal transition zone for endothelial cell therapy
Published 2021“…Transplanting these bioengineered constructs into in vivo models of corneal endothelial degeneration will prove the efficacy and viability, and the long-term maintenance of functional endothelium. …”
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Journal Article -
2390
The Effects of DEAD-box Helicase Activity on Biomolecular Condensate Structure and Dynamics
Published 2023“…Enzymatic processes which control condensate properties are of particular interest to biologists attempting to understand the function of biomolecular condensates, bioengineers looking for control points in manipulating condensates, and physicists interested in active materials. …”
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Thesis -
2391
3D-printed membrane for guided tissue regeneration
Published 2017“…Three-dimensional (3D) printing is currently being intensely studied for a diverse set of applications, including the development of bioengineered tissues, as well as the production of functional biomedical materials and devices for dental and orthopedic applications. …”
Journal article -
2392
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2393
Structural analysis of the cattle antibody repertoire
Published 2022“…The limited impact of light chain selection on antibody function provides little insight to bovine B cell development. Bioengineers of the ultralong CDR3H may wish to consider the light chain sequence should their targeted epitope lie within deep groves of known geometry, however at present, light chain selection is only a minor consideration in the development of bovine ultralong CDR3H antibodies as diagnostic, therapeutic or research tools.…”
Thesis -
2394
Stem and progenitor cells in wound healing
Published 2014“…<p>As more patients with large body surface area burns are surviving and requiring reconstructive surgery, there is a necessity for advances in the provision of bioengineered alternatives to autologous skin cover. …”
Thesis -
2395
Towards extracellular vesicle based gene therapy for Huntington's disease
Published 2016“…In examining EVs as a carrier for therapeutics for neurological diseases including HD, it was found that targeting can increase brain accumulation of EVs but that the physiological characteristics of EVs which make them susceptible to clearance by the reticuloendothelial system (RES) must be further evaluated to bioengineer modified EVs to avoid fast clearance. Lastly, loading by electroporation was found to induce siRNA aggregation which can lead to overestimation of loading by increasing siRNA content in an ultracentrifugation pellet, but cholesterol-conjugated siRNA mixed with EVs was capable of generating silencing <em>in vitro</em>.…”
Thesis -
2396
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2397
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2398
Cardiac stem cell therapy for heart failure
Published 2012“…The objective of this project was to test the following hypotheses: that a bioengineered heart extracellular matrix (ECM) with preserved intact geometric structure could be generated using decellularization by coronary perfusion; and that autologous CSCs, to repopulate this ECM, could be isolated and expanded from the adult heart, with the caveat that autologous CSCs are depleted and impaired by both aging and chronic dilated cardiomyopathy. …”
Thesis -
2399
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2400