Cosmetic outcomes of simple facial laceration suturing in the pediatric emergency department by Eyal Reiss, Yoav Gronovich, Eyal Heiman, Elad Sela, Giora Weiser

“…Cosmetic outcomes of simple facial lacerations sutured within 1 year of the study were reviewed using digital photographs taken by legal guardians of children sutured in the department. The photographs were reviewed and rated blindly using the Stony Brook scar score as measures of cosmetic outcomes by 2 plastic surgeons and 1 PEP, as well as the general numeric score (GNS) rated by the guardians and the 3 doctors. …”
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Use of Virtual Reality in the Reduction of Pain After the Administration of Vaccines Among Children in Primary Care Centers: Protocol for a Randomized Clinical Trial by Mercedes de la Cruz Herrera, Aïna Fuster-Casanovas, Queralt Miró Catalina, Mireia Cigarrán Mensa, Pablo Alcántara Pinillos, Isabel Vilanova Guitart, Sergi Grau Carrión, Josep Vidal-Alaball

“…Due to the nature of the VR intervention, it will be impossible to blind the patients, caregivers, or observers. However, a blind third-party assessment will be carried out. …”
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The Amagugu intervention to increase disclosure of maternal HIV to HIV-uninfected primary-school aged children in Southern Africa: A randomised controlled trial by Rochat, T, Stein, A, Cortina-Borja, M, Tanser, F, Bland, R

“…We used computer-generated simple random sampling with blinded assessment. The Amagugu intervention included six home-based counselling sessions; the enhanced standard of care included one clinic-based counselling session. …”

Public engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learnt by Dahal, A, Shakya, M, Pant, D, Adhikari, A, Colin-Jones, R, Theiss-Nyland, K, Pollard, AJ, Basnyat, B, Shrestha, S

“…To generate evidence on the impact of Typhoid Conjugate Vaccine (TCV), a phase 3, double-blind, randomized controlled trial was conducted in Lalitpur, Nepal. 20,000 children aged between 9 months and ≤16 years were vaccinated with a new TCV, or control vaccine. …”

Brief internet-delivered cognitive-behavioural intervention for children and adolescents with symptoms of anxiety and depression during the COVID-19 pandemic: a randomised controll... by Caio Borba Casella, Pedro Fonseca Zuccolo, Luisa Sugaya, Aline Santana de Souza, Luara Otoch, Fernanda Alarcão, Wagner Gurgel, Daniel Fatori, Guilherme V. Polanczyk

“…A blinded assessor will collect data on symptoms of anxiety, depression and irritability, at baseline, at the end of the intervention and 30 days thereafter. …”
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Public engagement during a typhoid conjugate vaccine trial in Lalitpur, Nepal- experience, challenges and lessons learnt by Ashata Dahal, Mila Shakya, Dikshya Pant, Anup Adhikari, Rachel Colin-Jones, Katherine Theiss-Nyland, Andrew J. Pollard, Buddha Basnyat, Shrijana Shrestha

“…To generate evidence on the impact of Typhoid Conjugate Vaccine (TCV), a phase 3, double-blind, randomized controlled trial was conducted in Lalitpur, Nepal. 20,000 children aged between 9 months and ≤16 years were vaccinated with a new TCV, or control vaccine. …”
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Effects of a home-based exercise combined yoga and resistance training in enthesitis-related arthritis in China: study protocol for a randomised controlled trial by Mei Zhang, Nan Chen, Jiaoyu Li, Yue Su, Guimei Guo

“…This study will require informed consent from all subjects and guardians of children under 18 years of age. The findings will be published in a peer-reviewed journal and international conferences.Trial registration number ChiCTR2300073446.…”
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Protocol for the safety and efficacy of fecal microbiota transplantation liquid in children with autism spectrum disorder: a randomized controlled study by Jinying Wei, Jiayi Chen, Xiaohui Fang, Tianyu Liu, Yanhan Yuan, Jinping Zhang

“…Nonetheless, there is still no agreement regarding the optimal dosage or duration of FMT treatment for individuals with ASD.MethodsThis clinical study is a double-blind, randomized, interventional trial conducted at a single center. …”
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Play brick therapy to aid the social skills of children and young people with autism spectrum disorder: the I-SOCIALISE cluster RCT by Barry Wright, Ellen Kingsley, Cindy Cooper, Katie Biggs, Matthew Bursnall, Han-I Wang, Tim Chater, Elizabeth Coates, M Dawn Teare, Kirsty McKendrick, Gina Gomez de la Cuesta, Amy Barr, Kiera Solaiman, Anna Packham, David Marshall, Danielle Varley, Roshanak Nekooi, Steve Parrott, Shehzad Ali, Simon Gilbody, Ann Le Couteur

“…Questionnaires completed by children and young people, their parents/guardians and teachers were used to look at the intervention’s effects. …”
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Cognitive behavior therapy for autistic adolescents, awareness and care for my autistic traits program: a multicenter randomized controlled trial by Fumiyo Oshima, William Mandy, Mikuko Seto, Minako Hongo, Aki Tsuchiyagaito, Yoshiyuki Hirano, Chihiro Sutoh, Siqing Guan, Yusuke Nitta, Yoshihito Ozawa, Yohei Kawasaki, Toshiyuki Ohtani, Jiro Masuya, Noriko Takahashi, Noriyuki Sato, Shizuka Nakamura, Akiko Nakagawa, Eiji Shimizu

“…The secondary outcomes included the change in Autism Knowledge Quiz-Parent, reduced treatment stigma, and improved mental health and social adaptation among autistic adolescents and their parents/guardians. A primary outcome measure scale was scored by assessors who were blind to the group assignment. …”
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Effects of high-intensity interval training, moderate-intensity continuous training, and guideline-based physical activity on cardiovascular metabolic markers, cognitive and motor... by Peng Yu, Peng Yu, Zicheng Zhu, Jiahui He, Bohua Gao, Qi Chen, Yifan Wu, Jing Zhou, Yixuan Cheng, Jitao Ling, Jing Zhang, Ao Shi, Ao Shi, Huijing Huang, Runlu Sun, Runlu Sun, Yan Gao, Weiguang Li, Xiao Liu, Xiao Liu, Zhiwei Yan, Zhiwei Yan

“…Informed consent will be obtained from all participants or their guardians. Upon completion, the authors will submit their findings to a peer-reviewed journal or academic conference for publication.Clinical trial registrationChinese Clinical Trial Registry, identifier ChiCTR2200061573.…”
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The early use of Antibiotics for At-risk children with InfluEnza in Primary Care (the ARCHIE programme) by Wang Kay, Tonner Sharon, Semple Malcolm G, Wolstenholme Jane, Perera Rafael, Harnden Anthony

“…Participants General practitioners and parents/guardians of at-risk children who previously had influenza-like illness participated in work package B. …”
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One-session treatment compared with multisession CBT in children aged 7–16 years with specific phobias: the ASPECT non-inferiority RCT by Barry Wright, Lucy Tindall, Alexander J Scott, Ellen Lee, Katie Biggs, Cindy Cooper, Penny Bee, Han-I Wang, Lina Gega, Emily Hayward, Kiera Solaiman, M Dawn Teare, Thompson Davis, Karina Lovell, Jon Wilson, Dean McMillan, Amy Barr, Hannah Edwards, Jennifer Lomas, Chris Turtle, Steve Parrott, Catarina Teige, Tim Chater, Rebecca Hargate, Shehzad Ali, Sarah Parkinson, Simon Gilbody, David Marshall

“…Outcome assessors remained blind to treatment allocation. Main outcome measures: The primary outcome measure was the Behavioural Avoidance Task at 6 months’ follow-up. …”
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Reliability of pain assessment by parents and attending emergency medical officers of pediatric patients presenting with acute pain at emergency department Hospital Universiti... by Sarah, Shaikh Abdul Karim

“…Their accompanying parents or guardians and attending Emergency Medical Officers (EDMO) blinded to one another were given Visual Analog Scale to assess respective childpatients pain. …”
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Evaluation of efficacy, outcomes and safety of infant haemodialysis and ultrafiltration in clinical use: I-KID a stepped wedge cluster RCT by Heather Lambert, Shaun Hiu, Malcolm Coulthard, John N S Matthews, Ruth Wood, Jean Crosier, Rachel Agbeko, Thomas Brick, Heather Duncan, David Grant, Quen Mok, Andrew Gustaf Nyman, John Pappachan, Paul Wellman, Chris Boucher, Joe Bulmer, Denise Chisholm, Kirsten Cromie, Victoria Emmet, Richard Feltbower, Michael Grayling, Rebecca Harrison, Eva-Maria Holstein, Ciara A Kennedy, Elaine McColl, Kevin Morris, Lee Norman, Julie Office, Roger Parslow, Christine Pattinson, Shriya Sharma, Jonathan Smith, Alison Steel, Rachel Steel, Jayne Straker, Lamprini Vrana, Jenn Walker, Mike Whitaker, Jim Wightman, Nina Wilson, Lucy Wirz

“…Design A clinical investigation using a non-blinded cluster stepped wedge design with paediatric intensive care units randomised to sequences. …”
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Exploring the knowledge, attitudes, and practice towards child eye health: A qualitative analysis of parent experience focus groups. by Sadik Taju Sherief, Samson Tesfaye, Zelalem Eshetu, Asim Ali, Helen Dimaras

“…<h4>Background</h4>The majority of childhood blindness causes in low-income countries are treatable or avoidable. …”
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Amblyopic patient adherence under patching treatment by Mayo Kayann Guerra Silva Tavares, Cassiano Rodrigues Isaac, Rodrigo Machado Cruz, Adriana Sobral Lourenço, Lorenna Cristina de Oliveira Éckeli, Núbia Vanessa A. Lima

“…Methods: This is a prospective, randomized, blinded clinical trial. The patients’ parents or legal guardians in the intervention group received text messages reminding them of the importance of patching. …”
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Comparison of S-ketamine and midazolam for intravenous preoperative sedative and anxiolytic effects in preschool children: study protocol for a randomized controlled clinical trial by Meng-Qiu Zhang, Ming-Zhe Xu, Yi He, Yong-Wei Su, Jun Ma, Yun-Xia Zuo

“…Methods This is a patient- and assessor-blinded randomized controlled clinical trial. Participants (n = 110) will receive S-ketamine (0.5 mg/kg) or midazolam (0.08 mg/kg) intravenously administrated at a ratio of 1:1 in the anaesthesia holding area. …”
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Safety and Immunogenicity of a <i>Shigella</i> Bivalent Conjugate Vaccine (ZF0901) in 3-Month- to 5-Year-Old Children in China by Yi Mo, Wenjian Fang, Hong Li, Junji Chen, Xiaohua Hu, Bin Wang, Zhengli Feng, Honghua Shi, Ying He, Dong Huang, Zhaojun Mo, Qiang Ye, Lin Du

“…No licensed <i>Shigella</i> vaccine is presently available globally. A double-blinded, randomized, placebo-controlled, age descending phase II clinical trial of a bivalent conjugate vaccine was studied in China. …”
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A Brief Digital Screening and Intervention Tool for Parental and Adolescent Tobacco and Electronic Cigarette Use in Pediatric Medical Care in Canada: Protocol for a Pilot Randomize... by Nicholas Chadi, Emile Diamant, Tamara Perez, Afnan Al-Saleh, Marie-Pierre Sylvestre, Jennifer O’Loughlin, Jonathan P Winickoff, Olivier Drouin

“…MethodsWe will approach parents or guardians of children aged between 0 and 17 years, as well as adolescent patients aged between 14 and 17 years, from a tertiary care pediatric hospital in Montreal, Quebec, Canada, for participation in this single-blinded, pilot randomized controlled trial. …”
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