The Influence of Physicality and Remote Collaboration in Moments of Design Convergence by Gowen, Jordan H.

“…The COVD-19 pandemic forced the world into a natural experiment, one that brings into sharp relief the potential and the limitations of our economy’s capacity to support remote collaboration. …”
Get full text

Can Batch Reverse Osmosis Make Desalination More Affordable and Sustainable? by Wei, Quantum J.

“…Incomplete flushing of brine from cycle-to-cycle leads to an elevated feed salinity relative to the feed intake, boosting energy consumption by about ∼10%. …”
Get full text

The Integrated State: Architecture, Planning, and Politics in Mexico, 1938-1958 by López, Albert José-Antonio

“…An important faction of Mexican Architects argued their indispensability to political society and appealed to popular support via print journalism, but also public speeches, and use of other mass forms of media, in a broad and long-term collective mobility project. …”
Get full text

Implementing CAST and Designing the STAMP-Enhanced Learning And Reporting System by Wong, Lawrence Man Kit

“…The proposed safety interventions had broad system coverage, the potential for hazard elimination and could prevent dissimilar incidents. …”
Get full text
Get full text

Kinetic and Thermodynamic Aspects of Voltage as a Driving Force for Ammonia Activation by Schiffer, Zachary J

“…In this thesis, I first propose a paradigm where electrochemical systems enable bond-formation steps in the chemical industry, leveraging voltage as an alternative driving force to enable operation at mild temperatures and pressures. …”
Get full text

Interfaces and Models for Improved Understanding of Real-World Communicative and Affective Nonverbal Vocalizations by Minimally Speaking Individuals by Narain, Jaya

“…While this work was motivated by impact for a small, specialized population, the results can inform the design of real-world data collection and modeling approaches more broadly.…”
Get full text

The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope by Yoon, Jimin, Nekongo, Emmanuel E, Patrick, Jessica E, Hui, Tiffani, Phillips, Angela M, Ponomarenko, Anna I, Hendel, Samuel J, Sebastian, Rebecca M, Zhang, Yu Meng, Butty, Vincent L, Ogbunugafor, C Brandon, Lin, Yu-Shan, Shoulders, Matthew D

“…Intriguingly, and in contrast, specific regions of Env, including regions targeted by broadly neutralizing antibodies, display enhanced mutational tolerance when XBP1s is induced, hinting at a role for host proteostasis network hijacking in potentiating antibody escape. …”
Get full text

Supermassive black holes in cosmological simulations – II: the AGN population and predictions for upcoming X-ray missions by Habouzit, Mélanie, Somerville, Rachel S, Li, Yuan, Genel, Shy, Aird, James, Anglés-Alcázar, Daniel, Davé, Romeel, Georgiev, Iskren Y, McAlpine, Stuart, Rosas-Guevara, Yetli, Dubois, Yohan, Nelson, Dylan, Banados, Eduardo, Hernquist, Lars, Peirani, Sébastien, Vogelsberger, Mark

“…Athena, AXIS, and LynX) will bring faint AGNs to light and new powerful constraints. …”
Get full text

Supermassive black holes in cosmological simulations – II: the AGN population and predictions for upcoming X-ray missions by Habouzit, Mélanie, Somerville, Rachel S, Li, Yuan, Genel, Shy, Aird, James, Anglés-Alcázar, Daniel, Davé, Romeel, Georgiev, Iskren Y, McAlpine, Stuart, Rosas-Guevara, Yetli, Dubois, Yohan, Nelson, Dylan, Banados, Eduardo, Hernquist, Lars, Peirani, Sébastien, Vogelsberger, Mark

“…Athena, AXIS, and LynX) will bring faint AGNs to light and new powerful constraints. …”
Get full text

Full-field stress computation from measured deformation fields: A hyperbolic formulation by Cameron, Benjamin C, Tasan, CCem

“…The solution of this class of problems is well established and hence the equations can be solved to give the solution for any geometry and loading condition, enabling broad applicability to a variety of problems. We provide a numerical proof-of-principle study of the plastic deformation of a two-dimensional bar with spatially varying yield stress and strain hardening coefficient. …”
Get full text

Discrete Continuum Robotic Structures by Rubio, Alfonso Parra

“…That enables generating continuum macroscopic foams with controlled deformation that could pre- serve some properties and help bring simplicity to overcome tasks that, with classic rigid-joint mechanical systems, would require a very complex system. …”
Get full text
Get full text

Mapping Genotype to Phenotype with High-Throughput Empirical Approaches by Lawrence, Katherine

“…At the scale of a single protein, we considered the binding landscape of broadly neutralizing antibodies (bnAbs) that confer protection against diverse influenza strains. …”
Get full text

Theory-constrained Data-driven Model Selection, Specification, and Estimation: Applications in Discrete Choice Models by Aboutaleb, Youssef Medhat

“…This thesis provides a framework, along with demonstrated applications, for carefully bringing data-driven flexibility to the specification and model selection of discrete choice models; while, at the same time, maintaining usability for analysis. …”
Get full text
Get full text

What's at stake in political messaging? by Hewitt, Luke

“…These findings suggest two broad lessons for future research. First, ‘what works’ in persuasion is context/issue-dependent. …”
Get full text

Language learning at scale: Data‐driven and model‐motivated analyses of lexical and morphological development by Braginsky, Mika

“…This work establishes a framework for conducting analyses of large‐scale language learning data in a way that brings together disparate data sources, generalizes across languages, and tracks change over development. …”
Get full text

A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis by Wang, Ruoxi Wendy

“…Second, we study the role of frequent chromosome 8 (chr8) gain in Ewing sarcoma, a pediatric bone and soft tissue tumor that is mainly driven by the EWS-FLI1 fusion oncogene. …”
Get full text

Differential analysis of scRNA-Seq data to characterize epithelial cells in health and disease by Nyquist, Sarah Kate

“…Studies of these tissues and the cells of which they are composed can allow us to better understand how epithelia respond to diverse perturbations, leading to broad insights in how to mitigate dysfunction and promote health. …”
Get full text

The Institutionalization of the American Dream by Geoghegan, James G.

“…This thesis introduces a more flexible housing offering for consumers looking to enter more established single-family communities, particularly in the Northeast region of the United States where the recent Single-Family Rent (“SFR”) and Build to Rent (“BTR”) models have yet to become broadly institutionalized. Due to the binary own vs rent decision tree that consumers in these established markets face, there are limited options to align investment with occupancy decisions. …”
Get full text

A Predictive Model for Pancreatic Cancer Diagnosis by Xiong, Thomas

“…In this scenario, we envision that our model would be integrated into hospital EHR systems and routinely and automatically run over broad patient populations as EHR data is collected over time to produce a history of patient risk scores as patient data becomes available. …”
Get full text

Imaging through optical multimode fiber: towards ultra-thin endoscopy by Lee, Szu-Yu

“…The focus of this dissertation research is therefore to study waveguide physics of MMF and to innovate powerful computational methods as compensatory strategies that enable high fidelity imaging and sensing through the fiber: We developed numerical simulation toolboxes and experimental measurement systems to characterize bi-directional light transport through MMF; By modeling the light transmission through MMF and sample interaction with matrix operations, we demonstrated three-dimensional (3D) label-free multi-modal imaging based on computational reconstruction; To facilitate multi-spectral and broadband operations with MMF, we established a parametric dispersion model for efficient fiber calibration across a broad spectrum; The spatio-temporal modes within the MMF can be conveniently leveraged for depth sensing, where we created a high-resolution and long-range axial profiling system using MMF; Finally, we showed a proximal MMF calibration method for implementing flexible MMF-based endoscopes by exploiting the waveguide physics and numerical optimization.…”
Get full text
Get full text