Regulation of presynaptic Ca2+ channel abundance at active zones through a balance of delivery and turnover by Cunningham, Karen L, Sauvola, Chad W, Tavana, Sara, Littleton, J Troy

“…To probe mechanisms that determine AZ Cac abundance, intravital FRAP and Cac photoconversion were used to separately measure delivery and turnover at individual AZs over a multi-day period. Cac delivery occurs broadly across the AZ population, correlates with AZ size, and is rate-limited by α2δ. …”
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Query-Driven Adaptive Sampling by Ayton, Benjamin James

“…In this thesis, we develop a single approach for a broad range of adaptive sampling missions with risk and limited prior knowledge. …”
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Integration of amino acid signals by the mTORC1 pathway by Valenstein, Max L.

“…To regulate growth, cells must integrate a broad array of environmental cues to coordinate anabolic and catabolic processes. …”
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Dolomite as a paleoenvironmental archive by Wilcots, Julia

“…The questions of how ancient dolomite formed — the longstanding “dolomite problem” — therefore has broad implications for our ability to use carbonate rocks to reconstruct surface environments throughout time. …”
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Template-directed Assembly of Silk in Advanced Materials for Food Security by Sun, Hui

“…Motivated by the pressing need to ensure food security for the fast-growing population, this thesis is dedicated to bringing biomaterials-based innovation in agriculture and food production, by developing new ways of nanofabrication with structural biopolymers (e.g. silk proteins) to generate macroscopic yet nanostructured functional materials that can be interfaced with food and plants. …”
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Structural and biochemical investigations into the Neisseria gonorrhoeae ribonucleotide reductase by Levitz, Talya S.

“…This work will open the door for future research on the N. gonorrhoeae RNR as a potential antibiotic target and for use of the chameleon for generation of high resolution reconstruction for a broad range of difficult cryo-EM samples.…”
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Evaluation of Introducing Technologies to Bridge Inspection and Maintenance in Japan by Nakajima, Kosuke

“…The literature reviews and interviews with bridge owners identify the potential problems and needs of the bridge owners in chapter 2. Chapter 3 broadly explains the technologies, such as data collection devices, and introduces the digital twin concept as a potential solution in the future to approach the identified problems. …”
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Analytical Modeling of a Heaving Wave Energy Converter by Tyshchenko, Valeriia

“…A broad review of wave power is offered, covering its history as well as the gaps and barriers in its development. …”
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Foundations of Cognitive, Affective, and Communicative Systems for Neurodiverse Individuals by Johnson, Kristina T.

“…In many respects, these individuals possess some of the greatest need and potential for scientific inquiry and advancement; yet they are difficult to bring into clinics, almost impossible to assess using a single modality, and often cannot provide accurate verbal indicators of how they are feeling or what they are thinking. …”
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Mechanical integration between cytoplasmic networks during cytokinesis by Pelletier, James F.

“…This thesis addresses force generation and cytoplasmic organization during cytokinesis at two levels: how do the emergent mechanics of cells facilitate cytokinesis, and how do these mechanics emerge from their molecular composition and interactions? These broad questions were addressed in two systems: eggs of the frog Xenopus laevis, and JCVI-syn3.0, a genomically minimized bacterium derived from Mycoplasma mycoides. …”
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Identifying functional groups in microbial communities based on ecological patterns by Shan, Xiaoyu

“…Guided by the computational prediction, I successfully isolate a member of this group that is a novel species with a broad spectrum of interaction against various Vibrio pathogens. …”
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Materials At Extremes: Shock-induced Fracture and Phase Transitions by Lem, Jet

“…Owing to the high-pressures and strain-rates associated with shock waves, their study is of great interest to a host of different fields including, but not limited to, planetary sciences, medical applications, sports science, aerospace engineering, chemistry, and materials science. Most broadly, the study of shock wave can be broken into two categories; the destructive and the constructive. …”
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Computational Study of Vaccination Strategies to Change B Cell Immunodominance by Yang, Leerang

“…Moreover, as the immune system preferentially targets immunodominant epitopes, functionally important and conserved epitopes are less targeted, which poses a barrier to the generation of broadly neutralizing antibodies. Computational modeling offers a valuable tool for understanding how immunodominance arises from the stochastic and dynamic processes of immune response. …”
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Expanding the CRISPR Toolbox for Engineering Lycopene Biosynthesis in Corynebacterium glutamicum by Zhan, Zhimin, Chen, Xiong, Ye, Zhifang, Zhao, Ming, Li, Cheng, Gao, Shipeng, Sinskey, Anthony J., Yao, Lan, Dai, Jun, Jiang, Yiming, Zheng, Xueyun

“…By optimizing the promoter, ORI and PAM sequences, the CRISPR/MAD7 system facilitated highly efficient gene deletion and exhibited a broad spectrum of PAM sites. Notably, 25 kb of DNA from the genome was successfully deleted. …”
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An Approach to Fault Management Design for the Proposed Mars Sample Return EDL and Ascent Phase Architectures by Mao, Cici

“…The Mars Sample Return (MSR) campaign aims to bring Martian regolith samples back to Earth. JPL is currently developing the Sample Retrieval Lander (SRL) to receive the samples collected by the Perseverance rover and launch them into Mars orbit using a Mars Ascent Vehicle (MAV) for future Earth return. …”
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Designing Electricity Distribution Network Tariffs for Beneficial Electrification by Turk, Graham

“…Decarbonizing the transportation and residential building sectors will require rapid electrification through the uptake of electric vehicles (EVs) and cold climate heat pumps (CCHPs), respectively. There is broad consensus that the flat volumetric electricity tariffs currently in place for residential customers in most of the US discourage electrification and do not reflect the underlying marginal costs of electricity delivery. …”
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From Words to Worlds: Bridging Language and Thought by Wong, Lionel Catherine

“…Human language offers a broad window into the landscape of our thoughts. …”
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Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging – A Symposium Review by Marchant, Joshua K., Ferris, Natalie G., Grass, Diana, Allen, Magdelena S., Gopalakrishnan, Vivek, Olchanyi, Mark, Sehgal, Devang, Sheft, Maxina, Strom, Amelia, Bilgic, Berkin, Edlow, Brian, Hillman, Elizabeth M. C., Juttukonda, Meher R., Lewis, Laura

“…“Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging” brought together researchers who use a broad range of imaging techniques to study brain structure and function at the convergence of the microscopic and macroscopic scales. …”
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Artificial Intelligence and the US-China Balance of Power by Chang, Benjamin Angel

“…Finally, the third essay exploits supply chain datasets to assess each side’s ability to bring AI-enabled autonomous weapons to bear in future conventional conflicts. …”
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Oblivious routing of highly variable traffic in service overlays and IP backbones by Sengupta, Sudipta, Lakshman, T. V., Kodialam, Murali, Orlin, James B.

“…For our evaluations, we use actual Internet Service Provider topologies collected for the Rocketfuel project. We also bring out the versatility of the scheme in not only handling widely fluctuating traffic but also accommodating applicability to several widely differing networking scenarios, including i) economical Virtual Private Networks (VPNs); ii) supporting indirection in specialized service overlay models like Internet Indirection Infrastructure (i3); iii) adding QoS guarantees to services that require routing through a netwo- - rk-based middlebox; and iv) reducing IP layer transit traffic and handling extreme traffic variability in IP-over-optical networks without dynamic reconfiguration of the optical layer. …”
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