The Evolution of Pd by Sather, Aaron C., Buchwald, Stephen Leffler

“…The use of transition metals to affect C-F bond formation has provided some useful alternatives, but a broadly applicable method remains elusive. …”
Get full text
Get full text
Get full text

Double/debiased machine learning for treatment and structural parameters by Chetverikov, Denis, Hansen, Christian, Robins, James, Chernozhukov, Victor V, Demirer, Mert, Duflo, Esther, Newey, Whitney K

“…The generic statistical theory of DML is elementary and simultaneously relies on only weak theoretical requirements, which will admit the use of a broad array of modern ML methods for estimating the nuisance parameters, such as random forests, lasso, ridge, deep neural nets, boosted trees, and various hybrids and ensembles of these methods. …”
Get full text
Get full text
Get full text
Get full text
Get full text

Maximizing ozone signals among chemical, meteorological, and climatological variability by Tilmes, Simone, Emmons, Louisa, Garcia-Menendez, Fernando, Brown-Steiner, Benjamin E, Selin, Noelle E, Prinn, Ronald G, Monier, Erwan

“…The strategies selected in this study are not limited to surface ozone data and could potentially maximize signal detection capabilities within a broad array of climate and chemical observations or model output.…”
Get full text
Get full text
Get full text
Get full text

Association of hypokalemia with an increased risk for medically treated arrhythmias by Phillips, Colin T., Wang, Junmei, Celi, Leo Anthony G., Zhang, Zhengbo, Feng, Mengling

“…Background Potassium replenishment protocols are often employed across broad patient populations to prevent cardiac arrhythmias. …”
Get full text

The Social Impact of STEM, Experienced: Studies With an Engineering Design Concept for Smart Devices by Nietner, Larissa Franciska, Wallace, David

“…This paper provides a broad review of relevant literature. It is proposed that creative, innovative engineering activities with perceived social impact may motivate middle and high school girls and build their confidence in the ability to impact people’s lives with technology they create. …”
Get full text

Two-stage reverse osmosis: optimal element configuration and energy savings by Wei, Quantum J., McGovern, Ronan Killian, Lienhard, John H

“…While innovations in membrane and pump technology are not likely to substantially decrease the energy consumption of the RO process, improved system designs have real potential to bring RO closer to its thermodynamic performance limit. …”
Get full text

An evaluation of global organic aerosol schemes using airborne observations by Pai, Sidhant J., Heald, Colette L., Pierce, Jeffrey R., Farina, Salvatore C., Marais, Eloise A., Jimenez, Jose L., Campuzano-Jost, Pedro, Nault, Benjamin A., Middlebrook, Ann M., Coe, Hugh, Shilling, John E., Bahreini, Roya, Dingle, Justin H., Vu, Kennedy

“…These include the ATom, KORUS-AQ, GoAmazon, FRAPPE, SEAC4RS, SENEX, DC3, CalNex, OP3, EUCAARI, ARCTAS and ARCPAC campaigns and provide broad coverage over a diverse set of atmospheric composition regimes - anthropogenic, biogenic, pyrogenic and remote. …”
Get full text

Advancing Fusion with Machine Learning Research Needs Workshop Report by Humphreys, David, Kupresanin, A., Boyer, M. D, Canik, J., Chang, C. S, Cyr, E. C, Granetz, R., Hittinger, J., Kolemen, E., Lawrence, E., Pascucci, V., Patra, A., Schissel, D.

“…This paper describes the results of a joint FES/ASCR DOE-sponsored Research Needs Workshop on Advancing Fusion with Machine Learning, held April 30–May 2, 2019, in Gaithersburg, MD (full report available at https://science.osti.gov/-/media/fes/pdf/workshop-reports/FES_ASCR_Machine_Learning_Report.pdf ). The workshop drew on broad representation from both FES and ASCR scientific communities, and identified seven Priority Research Opportunities (PRO’s) with high potential for advancing fusion energy. …”
Get full text

Autistic traits and individual brain differences: functional network efficiency reflects attentional and social impairments, structural nodal efficiencies index systemising and the... by Paul, Subhadip, Arora, Aditi, Midha, Rashi, Vu, Dinh, Roy, Prasun K, Belmonte, Matthew K

“…Conclusions Functional connectivities highlight distributed networks associated with domain-general properties such as attentional orienting and social cognition broadly, associating more impaired behaviour with more efficient brain networks that may reflect heightened feedforward information flow subserving autistic strengths and deficits alike. …”
Get full text

Circulating Factors in Trauma Plasma Activate Specific Human Immune Cell Subsets by Cahill, Laura A, Guo, Fei, Nguyen, Jennifer, Zhang, Fan, Seshadri, Anupamaa, Keegan, Joshua, Hauser, Carl J, Otterbein, Leo E, Robson, Simon, Shaefi, Shahzad, Yaffe, Michael B, Lederer, James A

“…Samples were stained with a broad immunophenotyping CyTOF antibody panel. Multiplex (Luminex) cytokine assays were used to measure differences in multiple cytokine levels in healthy and trauma plasma samples. …”
Get full text

How to subvert backdoored encryption: Security against adversaries that decrypt all ciphertexts

“…Our topics may be thought to fall broadly within the realm of steganography. However, we deal with the non-standard setting of an adversarially chosen distribution of cover objects (i.e., a stronger-than-usual adversary), and we take advantage of the fact that our cover objects are ciphertexts of a semantically secure encryption scheme to bypass impossibility results which we show for broader classes of steganographic schemes. …”
Get full text

How to subvert backdoored encryption: Security against adversaries that decrypt all ciphertexts by Horel, Thibaut, Park, Sunoo, Richelson, Silas, Vaikuntanathan, Vinod

“…Our topics may be thought to fall broadly within the realm of steganography. However, we deal with the non-standard setting of an adversarially chosen distribution of cover objects (i.e., a stronger-than-usual adversary), and we take advantage of the fact that our cover objects are ciphertexts of a semantically secure encryption scheme to bypass impossibility results which we show for broader classes of steganographic schemes. …”
Get full text

Planning for Anti-Displacement Development: An Affordable Housing Study in Central Falls by Cafferky, Patricia

“…These two forces – improved public transportation and an undervalued building stock ripe for redevelopment – have the potential to bring new sources of economic growth to a city which sorely needs it, to catalyze gentrification, and, by extension, to cause cultural and residential displacement. …”
Get full text

Integrating Machine Learning into Data Analysis and Plant Performance by Morey, Zachariah Keith

“…This thesis argues that while our project focused on a small benchmarking data set, machine learning and its benefits can be applied more broadly to data from the manufacturing facilities. …”
Get full text

Guiding principles for universal energy access: integrated distribution frameworks and their implementation by Jacquot, Grégoire

“…The primary contributions from this work include establishing the strong connection between the concept of integrated approaches to energy access and past and ongoing experiences in Sub- Saharan Africa; the identification of the key high-level institutional, regulatory, economic, and financial challenges facing the implementation of the Integrated Distribution Framework; a review of the potential of territorial utility concessions for the implementation of IDF and outlining possible guidelines to design IDF-like utility concessions for universal energy access; a brief analysis of the limitations of current mini-grid concessions in energy access and the need for further reforms to bring mini-grid concessions into the realm of IDF; an assessment of the role of solar concessions in harnessing the full potential of solar in universal energy access, and the challenges facing planners in the integration of off-grid solar into IDF; finally, a framework for the design and implementation of solar concessions. …”
Get full text

CuH-Catalyzed Olefin Functionalization: From Hydroamination to Carbonyl Addition by Liu, Richard Y., Buchwald, Stephen L.

“…This Account chronicles the development of this concept in our research group, highlighting its origin in the context of asymmetric hydroamination, evolution to more general C-X bond-forming reactions, and applications in the addition of olefin-derived nucleophiles to carbonyl derivatives.Hydroamination, the formal insertion of an olefin into the N-H bond of an amine, is a process of significant academic and industrial interest, due to its potential to transform widely available alkenes and alkynes into valuable complex amines. …”
Get full text

Tumors carrying BRAF-mutations over-express NAMPT that is genetically amplified and possesses oncogenic properties by Audrito, Valentina, Moiso, Enrico, Ugolini, Filippo, Messana, Vincenzo G., Brandimarte, Lorenzo, Manfredonia, Ilaria, Bianchi, Simonetta, De Logu, Francesco, Nassini, Romina, Szumera-Ciećkiewicz, Anna, Taverna, Daniela, Massi, Daniela, Deaglio, Silvia

“…Lastly, the over-expression of NAMPT in several tumors could be a key and broad event in tumorigenesis, substantiated by the finding of NAMPT gene amplification.…”
Get full text

Sparsity in Machine Learning: Theory and Applications by Lahlou Kitane, Driss

“…Indeed, on one hand interpretability can be key in a practice such as in healthcare, in which black box models cannot be used for the prescription of a treatment for a patient. …”
Get full text

Exploration of Disruption from Digital Transformation through the ARIES Framework Enterprise Element Model by Lucioli, Alessandro

“…Whilst a global pandemic is inherently a disruptive event, catalysing and bringing to the fore other disruption, change as a result of digital transformation has been present in business for at least the last decade manifesting in such things as change in business ecosystems and stakeholder landscapes (amongst others). …”
Get full text

Estimation and Optimization in Online Marketplaces by Li, Hanwei

“…The emergence of e-commerce business models (such as Airbnb and Amazon) brings opportunities and challenges to their operations. …”
Get full text