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    Identification of Early-Onset Metastasis in SF3B1 Mutated Uveal Melanoma by Wojtek Drabarek, Job van Riet, Josephine Q. N. Nguyen, Kyra N. Smit, Natasha M. van Poppelen, Rick Jansen, Eva Medico-Salsench, Jolanda Vaarwater, Frank J. Magielsen, Tom Brands, Bert Eussen, Thierry. P. P. van den Bosch, Robert M. Verdijk, Nicole C. Naus, Dion Paridaens, Annelies de Klein, Erwin Brosens, Harmen J. G. van de Werken, Emine Kilic, on behalf of the Rotterdam Ocular Melanoma Study Group

    Published 2022-02-01
    “…After stratification of all <i>SF3B1</i><sup>mut</sup> UM using short PFS vs. long PFS, only largest tumor diameter (LTD) was significantly larger (mean: 17.7 mm (±2.8 SD) in the short PFS <i>SF3B1</i><sup>mut</sup> group vs. the long PFS group (mean: 14.7 (±3.7 SD, <i>p</i> = 0.001). …”
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    Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding by Kardon, Julia R, Moroco, Jamie A, Engen, John R, Baker, Tania A

    Published 2021
    “…© 2020, eLife Sciences Publications Ltd. All rights reserved. Mitochondria control the activity, quality, and lifetime of their proteins with an autonomous system of chaperones, but the signals that direct substrate-chaperone interactions and outcomes are poorly understood. …”
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