Reaching supercritical field strengths with intense lasers by T G Blackburn, A Ilderton, M Marklund, C P Ridgers

“…We show that a collision between an electron beam with energy in the tens of GeV and a laser pulse of intensity ${10}^{24}\,{\rm{W}}\,{\mathrm{cm}}^{-2}$ at oblique, or even normal, incidence is a viable platform for studying the breakdown of perturbative strong-field QED. Our results have implications for the design of near-term experiments as they predict that certain quantum effects are enhanced at oblique incidence.…”
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Understanding the value and impacts of informal care for people living with poor mental health by J. Saunders

“…In short informal carers are fundamental to the functioning of any health and social care system; it is critical to therefore to invest in measures to support these caregivers and identify potential risk factors that might lead to a breakdown in caregiving support. …”
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The Rumen Epithelial Microbiota: Possible Gatekeepers of the Rumen Epithelium and Its Potential Contributions to Epithelial Barrier Function and Animal Health and Performance by Stephan Schmitz-Esser

“…The rumen epithelium fulfills critical physiological functions for the ruminant host in energy absorption, metabolism, and nutrient transport. …”
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Reproductive Immunology and Embryo Acceptance by Sarah Robertson

“…Advances over recent decades show that implantation and placental development depend on an active state of maternal immune tolerance, and breakdown of tolerance is a key contributor to infertility and recurrent pregnancy loss. …”
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Utilizing Lean Six Sigma and Waste Assessment Model to Reduce Waste in the Hot Rolled Coil Production by Kusumawardani Rindi, Supriyanto Hari, Suryanto Muhammad Rinaldi

“…Notably, the production process recorded defect ratios of 15.85%, 15.65%, and 15.56% from 2020 to 2022, with waste waiting accounting for a breakdown time and operating time ratio of ±40%. The study employs Lean Six Sigma to analyze and mitigate waste during HRC production, aiming to augment product value, production efficiency, and cost reduction. …”
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Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance by Sébastien This, Stefanie F. Valbon, Marie-Ève Lebel, Heather J. Melichar

“…The ability of T cells to identify foreign antigens and mount an efficient immune response while limiting activation upon recognition of self and self-associated peptides is critical. Multiple tolerance mechanisms work in concert to prevent the generation and activation of self-reactive T cells. …”
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Supersaturation-Dependent Formation of Amyloid Fibrils by Yuji Goto, Masahiro Noji, Kichitaro Nakajima, Keiichi Yamaguchi

“…On the other hand, there is increasing evidence that supersaturation plays a critical role in the formation of amyloid fibrils and the onset of amyloidosis. …”
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Parameter Optimization Design of the Commutation Circuit of a Hybrid DC-Current-Limiting Circuit Breaker by Zhiyong Lv, Jinwu Zhuang, Jin Wu, Luhui Liu, Zhifang Yuan, Zhuangxian Jiang, Xiangjun Wang

“…In order to further optimize the parameters of the commutation circuit, a mathematical model for optimization design was established. Taking the maximum critical breakdown voltage under unit capacitance energy as the objective function, the arcing time before commutating and the current-limiting inductance and capacitance are enumerated to obtain the optimized commutation circuit parameters. …”
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Dysfunctional problem-based learning curricula: resolving the problem by Lim William K

“…This paper describes the signs of a dysfunctional PBL curriculum to aid hybrid PBL schools in recognising curricular breakdown. Next it discusses alternative curricular strategies and costs associated with PBL. …”
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Adducin is involved in endothelial barrier stabilization. by Daniela Kugelmann, Jens Waschke, Mariya Y Radeva

“…Finally, we report that inflammatory mediator-induced endothelial barrier breakdown is associated with loss of α-adducin from the cell membrane. …”
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Autoimmune Neuroinflammatory Diseases: Role of Interleukins by Abdul Waheed Khan, Mariya Farooq, Moon-Jung Hwang, Muhammad Haseeb, Sangdun Choi

“…The interleukin (IL) family of cytokines, especially IL-1, IL-6, and IL-17, plays a critical role in the pathogenesis of these diseases. …”
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Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells by Guoqing Qian, Oluwaseun Adeyanju, Ayobami Olajuyin, Xia Guo

“…Diverse pathological processes are involved in the development of AAA, including aortic wall inflammation, elastin breakdown, oxidative stress, smooth muscle cell (SMC) phenotypic switching and dysfunction, and extracellular matrix degradation. …”
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Bidirectional Synchronous H6 Inverter for Hybrid AC/DC Distribution System With Improved Light Load Efficiency by Meshari Alshammari, Maeve Duffy

“…Existing topologies are evaluated for obtaining optimal efficiency as well as an investigation of loss breakdown at light-load using analytic models and PSIM simulation. …”
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Dopamine and beta-band oscillations differentially link to striatal value and motor control by Schwerdt, HN, Amemori, K, Gibson, DJ, Stanwicks, LL, Yoshida, T, Bichot, NP, Amemori, S, Desimone, R, Langer, R, Cima, MJ, Graybiel, AM

“…Coordinate dopamine-beta opposition is considered a normative rule for basal ganglia function. We report a breakdown of this rule. We developed multimodal systems allowing the first simultaneous, chronic recordings of dopamine release and beta-band activity in the striatum of nonhuman primates during behavioral performance. …”
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Analysis of the impact of automaker strategies on lithium price elasticity using a novel bottom-up demand model by Sullivan, Luke Robert

“…To reduce possible disruptions to the electric vehicle transition, an understanding of the demand and supply of key critical materials, materials with a high risk of supply chain disruption, is essential. …”
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An investigation of the numerical treatment of condensation by Sasson, Joseph, Schor, Andrei L.

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Electronic transport and device prospects of monolayer molybdenum disulphide grown by chemical vapour deposition by Zhu, Wenjuan, Low, Tony, Lee, Yi-Hsien, Wang, Han, Farmer, Damon B., Kong, Jing, Xia, Fengnian, Avouris, Phaedon, Yi-Hsien Lee

“…We show that these devices have the potential to suppress short channel effects and have high critical breakdown electric field. However, our study reveals that the electronic properties of these devices are at present severely limited by the presence of a significant amount of band tail trapping states. …”
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Modeling in microelectronics at microwave/millimeter-wave frequencies and innovative circuit design by Lim, Hong Yi

“…The active current which represents a major non-linearity of the HEMT is modeled with a proposed new current model to more accurately capture the characteristics at critical regions of the device characterization. The forward diode current model is also described and a similar equation form is adopted for the breakdown current model.…”
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Repair and maintenance cost of combine harvester in rice harvesting at Kedah / Mohammad Izwan Ismail by Ismail, Mohammad Izwan

“…The owner or farmer need to repair and maintained the combine harvester to reduce the factor that enhance combine harvester breakdown. This problem needs to overcome to reduce the losses to owner of combine harvester. …”
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Bisphosphonates: from bench to bedside. by Russell, R

“…Bisphosphonates are chemically stable analogues of inorganic pyrophosphate, and are resistant to breakdown by enzymatic hydrolysis. Bisphosphonates inhibit bone resorption by being selectively taken up and adsorbed to mineral surfaces in bone, where they interfere with the action of the bone-resorbing osteoclasts. …”