IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis by Qian Wang, Christin M Lepus, Harini Raghu, Laurent L Reber, Mindy M Tsai, Heidi H Wong, Ericka von Kaeppler, Nithya Lingampalli, Michelle S Bloom, Nick Hu, Eileen E Elliott, Francesca Oliviero, Leonardo Punzi, Nicholas J Giori, Stuart B Goodman, Constance R Chu, Jeremy Sokolove, Yoshihiro Fukuoka, Lawrence B Schwartz, Stephen J Galli, William H Robinson

“…Using genetic and pharmacologic approaches, we show that the IgE/FcεRI/Syk signaling axis is critical for the development of osteoarthritis. We find that mast cell-derived tryptase induces inflammation, chondrocyte apoptosis, and cartilage breakdown. …”
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Real-time adaptive algorithms for dial-a-ride problems by Pandi, Ramesh Ramasamy

“…Second, regardless of the technological advancements, vehicle breakdowns lead to major disruption of transportation services across the globe. …”
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Noninvasive Low-Intensity Focused Ultrasound Mediates Tissue Protection following Ischemic Stroke by Alexandra M. Kaloss, Lauren N. Arnold, Eman Soliman, Maya Langman, Nathalie Groot, Eli Vlaisavljevich, Michelle H. Theus

“…These findings correlated with a reduced area of IgG deposition in the cerebral cortex, suggesting attenuation of BBB breakdown under LIFU conditions. We also observed increased diameter of CD31-postive microvessels in the ischemic cortex. …”
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Welfare for Elites: The Student Health Center at Tokyo Imperial University and the Paradox of Medicare in Japanese Meritocracy by Jamyung CHOI

“…This university, I contend, was a critical locus in the birth of medical welfare in Japan. …”
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Nutrient Management Impacts on HLB-affected ‘Valencia’ Citrus Tree Growth, Fruit Yield, and Postharvest Fruit Quality by Alisheikh A. Atta, Kelly T. Morgan, Mark A. Ritenour, Davie M. Kadyampakeni

“…Although micronutrients exacerbated stem-end rind breakdown (SERB), these nutrients significantly improved fruit storage when the fruits were stored for extended periods (8–11 weeks). …”
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Perilipin 1 Deficiency Prompts Lipolysis in Lipid Droplets and Aggravates the Pathogenesis of Persistent Immune Activation in Drosophila by Lei Wang, Jiaxin Lin, Kaiyan Yang, Weina Wang, Yan Lv, Xiangkang Zeng, Yaya Zhao, Junjing Yu, Lei Pan

“…We find that deficiency of Plin1, a key regulator of LDs’ reconfiguration, blocks LDs minimization at the initial stage of immune hyperactivation but enhances LDs breakdown at the later stage of sustained immune activation via recruiting the lipase Brummer (Bmm, homologous to human ATGL). …”
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The Integration of Tools for the Techno-Economic Evaluation of Fixed and Floating Tidal Energy Deployment in the Irish Sea by Ross O’Connell, Mitra Kamidelivand, Ioannis Polydoros, Christopher Wright, Paul Bonar, Alison J. Williams, Jimmy Murphy

“…Four recently developed open-access software tools are used in this study to investigate the critical and expensive elements of potential demonstration and commercial scale tidal projects. …”
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Investigating and Modeling Ageing Effects on Polymeric Insulator Electrical Properties by Ali Ahmed Salem, Ahmed Allawy Alawady, Kwan Yiew Lau, Wan Rahiman, Zulkurnain Abdul-Malek, Samir Ahmed Al-Gailani, Salem Mgammal Al-Ameri, Enas Ali, Sherif S. M. Ghoneim

“…In addition, the aged polymeric insulator model based on an equivalent circuit model was developed to determine the leakage current and breakdown voltage of aged insulators. Moreover, an artificial neural network model is carried out to predict the critical leakage current and flashover voltage of the insulator under the ageing effect. …”
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Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia by Anders Lund Selli, Adrina Kalasho Kuzmiszyn, Natalia Smaglyukova, Timofey Kondratiev, Ole-Martin Fuskevåg, Georg Sager, Erik Sveberg Dietrichs

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The Use of Human Amniotic Membrane (hAM) as a Treatment Strategy of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Systematic Review and Meta-Analysis of the Literature by Roberto Sacco, Oladapo Akintola, Nicola Sacco, Alessandro Acocella, Monica Diuana Calasans-Maia, Massimo Maranzano, Sergio Olate

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Experimental Evaluation of Industrial Mushroom Waste Substrate Using Hybrid Mechanism of Vermicomposting and Effective Microorganisms by Khalid Ansari, Shantanu Khandeshwar, Charuta Waghmare, Hassan Mehboob, Tripti Gupta, Avinash N. Shrikhande, Mohamed Abbas

“…Based on the experimental analysis, [RWM+V+EM] accelerated the breakdown of organic matter and showed improvement compared with other composts in compostable materials, thus, emphasizing the critical nature of long-term mushroom waste management and treatment.…”
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Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits by Karen Krukowski, Austin Chou, Xi Feng, Brice Tiret, Maria-Serena Paladini, Lara-Kirstie Riparip, Myriam M. Chaumeil, Cynthia Lemere, Susanna Rosi

“…In addition, TBI is the strongest environmental risk factor for development of Alzheimer’s disease and other dementia-related neurodegenerative disorders. Critical changes that affect cognition take place over time following the initial insult. …”
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Agent Based Model of Anti-Vaccination Movements: Simulations and Comparison with Empirical Data by Pawel Sobkowicz, Antoni Sobkowicz

“…For a range of parameters, the simulations result in a relatively small fraction of people refusing vaccination, but a slight change in critical parameters (such as willingness to post anti-vaccination information) may lead to a catastrophic breakdown of vaccination support in the model society, due to nonlinear feedback effects. …”
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On the verge of a nervous breakthrough: Neoliberal subjectivities and precarious resistance in the contemporary South African university by Desmond Painter, Liezl Dick

“…The neoliberal machine hence operates with and through precarity (Pérez & Montoya, 2018), creating non-relational subjectivities always on the verge of a collective nervous-breakdown. Against this background we argue that the task of critical theory today is to think beyond diagnostic terms, towards possible forms of resistance that don’t only exist outside of the neoliberal context, but that are made possible by the neoliberal ethos itself. …”
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An exploration of health workers’ experiences in providing bereavement care to mothers following a stillbirth: results from a subnational level health system in Uganda by Eric Ssegujja, Isaac Ddumba, Michelle Andipatin

“…Reflection of unpreparedness to handle the tasks demonstrates a deficit in the required skills. It is a critical gap missing hence calling for dedicated efforts to address it. …”
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Synthesis of a New Molecularly Imprinted Polymer and Optimisation of Phenylglyoxylic Acid Extraction from Human Urine Samples Using a Central Composite Design within the Response S... by Murad. M. Qronfla, Bassem Jamoussi, Radhouane Chakroun, Bandar A. Al-Mur, Riyadh F. Halawani, Fahed A. Aloufi

“…Styrene, a chemical widely used in various industries, undergoes metabolic breakdown in the human body, resulting in the production of phenylglyoxylic acid (PGA). …”
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The Effect of Hybridisation on Mechanical Properties and Water Absorption Behaviour of Woven Jute/Ramie Reinforced Epoxy Composites by Cionita Tezara, Agung Efriyo Hadi, Januar Parlaungan Siregar, Zalinawati Muhamad, Mohammad Hazim Mohamad Hamdan, Ahmed Nurye Oumer, Jamiluddin Jaafar, Agustinus Purna Irawan, Teuku Rihayat, Deni Fajar Fitriyana

“…Recently, the most critical issue related to the use of natural fibre-reinforced polymer composites (NFRPC) is the degradation properties of composites exposed to the environment. …”
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Control of chilled meat of broiler chickens by bacterioscopic method by Alona Bohatko, Nadiia Bohatko, Svitlana Tkachuk

“…Rod-shaped gram-positive microorganisms dominated stale meat, in some places single cocci were recorded, including a considerable breakdown of muscle tissue. The content of volatile fatty acids in the chilled meat of broiler chickens and the acid value of fat increased significantly (Р<0.001) on the 8th day of sale at a temperature of 0-4°C, respectively – 11.05±0.37 − 10.97±0.33 and 2.83±0.33 mg of NaOH. …”
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Genome-Resolved Metagenomics Informs the Functional Ecology of Uncultured Acidobacteria in Redox Oscillated Sphagnum Peat by Linta Reji, Xinning Zhang

“…ABSTRACT Understanding microbial niche differentiation along ecological and geochemical gradients is critical for assessing the mechanisms of ecosystem response to hydrologic variation and other aspects of global change. …”
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Del LaZarillo al Occupy zombi: zombificaciones literarias y sociales para un nuevo siglo by Alvaro Llosa Sanz

“…Accordingly to this, the present paper focuses on how a classic picaresque novel –La vida de Lazarillo de Tormes y de sus fortunas y adversidades (1554)– has been transformed into a zombified story –LaZarillo: matar zombis nunca fue pan comido (2010)–, and how this literary transformation implies a critical rewriting of a canonical text in order to be able to link their historical concerns to a contemporary world devastated by a social breakdown mainly derived from the 2008 global financial crisis. …”
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