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821
Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner
Published 2022-05-01“…Mechanistically, we observed that NS1 treatment of cells triggered internalization of VE-cadherin, likely via clathrin-mediated endocytosis, and phosphorylation of β-catenin, part of a canonical IJC remodeling pathway during breakdown of endothelial barriers that activates glycogen synthase kinase-3β (GSK-3β). …”
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822
Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease
Published 2022-01-01“…Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. …”
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823
Protection of lipopolysaccharide-induced otic injury by a single dose administration of a novel dexamethasone formulation
Published 2023-10-01“…Abstract Background The blood-labyrinth barrier (BLB) separates the inner ear from the circulation and is critical for maintaining ionic homeostasis and limiting the entry of deleterious agents. …”
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824
Quantitative comparison of the spreading and invasion of radial growth phase and metastatic melanoma cells in a three-dimensional human skin equivalent model
Published 2017-09-01“…Interestingly, both the WM35 and SK-MEL-28 melanoma cells lead to a breakdown of the basement membrane and eventually enter the dermis. …”
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825
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826
Development of Materials for Extreme Environment Applications by Laser Powder Bed Fusion
Published 2023“…Microstructural analysis reveals breakdown of SiC and in-situ formation of silicides and carbides, which result in decreased porosity and grain size. …”
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Thesis -
827
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828
Thin-Capped Atheromata With Reduced Collagen Content in Pigs Develop in Coronary Arterial Regions Exposed to Persistently Low Endothelial Shear Stress
Published 2015“…By promoting an imbalance of attenuated synthesis and augmented collagen breakdown, low ESS favors the focal evolution of early lesions toward plaques with reduced collagen content and thin fibrous caps—2 critical determinants of coronary plaque vulnerability.…”
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829
Diffusive and drift halide perovskite memristive barristors as nociceptive and synaptic emulators for neuromorphic computing
Published 2021“…With the current research impetus on neuromorphic computing hardware, realizing efficient drift and diffusive memristors are considered critical milestones for the implementation of readout layers, selectors, and frameworks in deep learning and reservoir computing networks. …”
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Journal Article -
830
5-HT and depression: is the glass half-full?
Published 2011“…A long-standing theory is that a breakdown in brain serotonin (5-hydroxytryptamine; 5-HT) signalling is critically involved in the symptoms and drug treatment of clinical depression. …”
Journal article -
831
Enhancement and civic virtue
Published 2014“…We thus directly confront critics of biomedical enhancement who argue that it will lead to a loss of social cohesion and a breakdown in political life.…”
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832
The ogbanje who wanted to stay: The occult, belonging, family and therapy in Sierra Leone
Published 2016“…It argues that ogbanjes have to be understood as avengers who, in the name of society, penalize those deeds of women which meet with the disapproval of the community. Ogbanjes embody a breakdown of accepted social concepts as they are able to openly articulate criticism towards their parents and elders and thus serve as a way to negotiate the coming of age. …”
Journal article -
833
Disrupted Parenthood in Caryl Phillips’s The Final Passage
Published 2021-07-01“…By applying a postcolonial framework and including both canonical and recent texts produced in the field, this paper analyses how racial labels and assumptions weaken fragile bonds and further displace the characters as it also attempts to fill a gap since aspects of distress and breakdown are often neglected in literary criticism. …”
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834
Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel Disease-specific Transcriptomic Signatures
Published 2023-01-01“…Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and colonoids are a critical bench-to-bedside tool for studying the epithelium in inflammatory bowel disease. …”
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Article -
835
Through-silicon-via (TSV) design, fabrication and characterization for 3D IC applications
Published 2014“…In addition, TSV can also be designed and embedded in a 3D integrated circuit (IC) stack to assist in heat removal, which is a critical challenge facing 3D IC. Moreover, thermo-mechanical stress due to the mismatch of the coefficient of thermal expansion (CTE) between Si and TSV Cu core has critical effects on the active device performances in the vicinity of the TSV. …”
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Thesis -
836
Rutile and Chlorite Geochemistry Constraints on the Formation of the Tuwu Porphyry Cu Deposit, Eastern Tianshan and Its Exploration Significance
Published 2021-09-01“…These distinctive signatures can be used as critical indicators of porphyry-style Cu mineralization and may serve as a valuable tool in mineral exploration.…”
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837
Overexpression of the <i>Rubus idaeus</i> Polygalacturonases Gene <i>RiPG2</i> Accelerates Fruit Softening in <i>Solanum lycopersicum</i>
Published 2024-01-01“…The primary causes of fruit softening are the breakdown of components linked to the cell wall and the destruction of the cell wall structure itself. …”
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838
Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus
Published 2022-10-01“…Here, we show the linkage of the LD-associated lipase activation to the breakdown of LDs for the generation of free fatty acids (FFAs) at the late stage of diverse RNA viral infections, which represents a broad-spectrum antiviral target. …”
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839
Detection of Corona Faults in Switchgear by Using 1D-CNN, LSTM, and 1D-CNN-LSTM Methods
Published 2023-03-01“…The root cause of this issue is an electrical breakdown of the air due to electrical stress and poor air quality within the switchgear. …”
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840