Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner by Henry Puerta-Guardo, Scott B. Biering, Francielle Tramontini Gomes de Sousa, Jeffrey Shu, Dustin R. Glasner, Jeffrey Li, Sophie F. Blanc, P. Robert Beatty, Eva Harris

“…Mechanistically, we observed that NS1 treatment of cells triggered internalization of VE-cadherin, likely via clathrin-mediated endocytosis, and phosphorylation of β-catenin, part of a canonical IJC remodeling pathway during breakdown of endothelial barriers that activates glycogen synthase kinase-3β (GSK-3β). …”
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Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease by Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul R Heath, Stephen B Wharton, Sheila E Francis, Jason Berwick

“…Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. …”
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Protection of lipopolysaccharide-induced otic injury by a single dose administration of a novel dexamethasone formulation by Silvia Murillo-Cuesta, Ester Lara, Jose M. Bermúdez-Muñoz, Elena Torres-Campos, Lourdes Rodríguez-de la Rosa, Pilar López-Larrubia, Signe R. Erickson, Isabel Varela-Nieto

“…Abstract Background The blood-labyrinth barrier (BLB) separates the inner ear from the circulation and is critical for maintaining ionic homeostasis and limiting the entry of deleterious agents. …”
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Quantitative comparison of the spreading and invasion of radial growth phase and metastatic melanoma cells in a three-dimensional human skin equivalent model by Parvathi Haridas, Jacqui A. McGovern, Sean D.L. McElwain, Matthew J. Simpson

“…Interestingly, both the WM35 and SK-MEL-28 melanoma cells lead to a breakdown of the basement membrane and eventually enter the dermis. …”
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Experimental and modelling studies of pit-to-crack transition under corrosion fatigue conditions by Huang, Xuejun, Ph. D. Massachusetts Institute of Technology

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Development of Materials for Extreme Environment Applications by Laser Powder Bed Fusion by O'Brien, Alexander D.

“…Microstructural analysis reveals breakdown of SiC and in-situ formation of silicides and carbides, which result in decreased porosity and grain size. …”
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Methodology development for imaging histone modifications and for site-specific protein labeling in vitro and on the surface of living cells by Lin, Chi-Wang

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Thin-Capped Atheromata With Reduced Collagen Content in Pigs Develop in Coronary Arterial Regions Exposed to Persistently Low Endothelial Shear Stress by Koskinas, Konstantinos C., Baker, Aaron B., Papafaklis, Michail, Chatzizisis, Yiannis S., Jonas, Michael, Sukhova, Galina K., Coskun, Ahmet U., Quillard, Thibaut, Maynard, Charles, Antoniadis, Antonios P., Shi, Guo-Ping, Libby, Peter, Feldman, Charles L., Stone, Peter H., Edelman, Elazer R

“…By promoting an imbalance of attenuated synthesis and augmented collagen breakdown, low ESS favors the focal evolution of early lesions toward plaques with reduced collagen content and thin fibrous caps—2 critical determinants of coronary plaque vulnerability.…”
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Diffusive and drift halide perovskite memristive barristors as nociceptive and synaptic emulators for neuromorphic computing by John, Rohit Abraham, Yantara, Natalia, Ng, Si En, Muhammad Iszaki Bin Patdillah, Kulkarni, Mohit Rameshchandra, Nur Fadilah Jamaludin, Basu, Joydeep, Ankit, Mhaisalkar, Subodh Gautam, Basu, Arindam, Mathews, Nripan

“…With the current research impetus on neuromorphic computing hardware, realizing efficient drift and diffusive memristors are considered critical milestones for the implementation of readout layers, selectors, and frameworks in deep learning and reservoir computing networks. …”
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5-HT and depression: is the glass half-full? by Sharp, T, Cowen, P

“…A long-standing theory is that a breakdown in brain serotonin (5-hydroxytryptamine; 5-HT) signalling is critically involved in the symptoms and drug treatment of clinical depression. …”

Enhancement and civic virtue by Jefferson, W, Douglas, T, Kahane, G, Savulescu, J

“…We thus directly confront critics of biomedical enhancement who argue that it will lead to a loss of social cohesion and a breakdown in political life.…”

The ogbanje who wanted to stay: The occult, belonging, family and therapy in Sierra Leone by Schneider, L

“…It argues that ogbanjes have to be understood as avengers who, in the name of society, penalize those deeds of women which meet with the disapproval of the community. Ogbanjes embody a breakdown of accepted social concepts as they are able to openly articulate criticism towards their parents and elders and thus serve as a way to negotiate the coming of age. …”

Disrupted Parenthood in Caryl Phillips’s The Final Passage by Fediakova Anastasiia

“…By applying a postcolonial framework and including both canonical and recent texts produced in the field, this paper analyses how racial labels and assumptions weaken fragile bonds and further displace the characters as it also attempts to fill a gap since aspects of distress and breakdown are often neglected in literary criticism. …”
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Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel Disease-specific Transcriptomic Signatures by Tatiana A. Karakasheva, Yusen Zhou, Hongbo M. Xie, Gloria E. Soto, Tiana D. Johnson, Madison A. Stoltz, Daana M. Roach, Noor Nema, Chizoba N. Umeweni, Kaitlyn Naughton, Lauren Dolinsky, James A. Pippin, Andrew D. Wells, Struan F.A. Grant, Louis Ghanem, Natalie Terry, Amanda B. Muir, Kathryn E. Hamilton

“…Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and colonoids are a critical bench-to-bedside tool for studying the epithelium in inflammatory bowel disease. …”
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Through-silicon-via (TSV) design, fabrication and characterization for 3D IC applications by Zhang, Lin

“…In addition, TSV can also be designed and embedded in a 3D integrated circuit (IC) stack to assist in heat removal, which is a critical challenge facing 3D IC. Moreover, thermo-mechanical stress due to the mismatch of the coefficient of thermal expansion (CTE) between Si and TSV Cu core has critical effects on the active device performances in the vicinity of the TSV. …”
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Rutile and Chlorite Geochemistry Constraints on the Formation of the Tuwu Porphyry Cu Deposit, Eastern Tianshan and Its Exploration Significance by Xingying Wen, Fangfang Zhang, Yinhong Wang, Min Sun, Wei Zhang, Yanyan Li, Hang Zhou, Yiming Chen

“…These distinctive signatures can be used as critical indicators of porphyry-style Cu mineralization and may serve as a valuable tool in mineral exploration.…”
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Overexpression of the <i>Rubus idaeus</i> Polygalacturonases Gene <i>RiPG2</i> Accelerates Fruit Softening in <i>Solanum lycopersicum</i> by Tiemei Li, Xiao Guo, Yuxiao Chen, Jing Li, Caihong Yu, Zhifeng Guo, Guohui Yang

“…The primary causes of fruit softening are the breakdown of components linked to the cell wall and the destruction of the cell wall structure itself. …”
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Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus by Yeong-Bin Baek, Hyung-Jun Kwon, Muhammad Sharif, Jeongah Lim, In-Chul Lee, Young Bae Ryu, Jae-In Lee, Ji-Sun Kim, Young-Seung Lee, Dong-Hoon Kim, Sang-Ik Park, Don-Kyu Kim, Jeong-Sun Kim, Hyon E. Choy, Sunwoo Lee, Hueng-Sik Choi, Timothy F. Osborne, Tae-Il Jeon, Kyoung-Oh Cho

“…Here, we show the linkage of the LD-associated lipase activation to the breakdown of LDs for the generation of free fatty acids (FFAs) at the late stage of diverse RNA viral infections, which represents a broad-spectrum antiviral target. …”
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Detection of Corona Faults in Switchgear by Using 1D-CNN, LSTM, and 1D-CNN-LSTM Methods by Yaseen Ahmed Mohammed Alsumaidaee, Chong Tak Yaw, Siaw Paw Koh, Sieh Kiong Tiong, Chai Phing Chen, Talal Yusaf, Ahmed N Abdalla, Kharudin Ali, Avinash Ashwin Raj

“…The root cause of this issue is an electrical breakdown of the air due to electrical stress and poor air quality within the switchgear. …”
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Reward Deficiency Syndrome (RDS) Surprisingly Is Evolutionary and Found Everywhere: Is It “Blowin’ in the Wind”? by Kenneth Blum, Thomas McLaughlin, Abdalla Bowirrat, Edward J. Modestino, David Baron, Luis Llanos Gomez, Mauro Ceccanti, Eric R. Braverman, Panayotis K. Thanos, Jean Lud Cadet, Igor Elman, Rajendra D. Badgaiyan, Rehan Jalali, Richard Green, Thomas A. Simpatico, Ashim Gupta, Mark S. Gold

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