Cytomegalovirus (CMV)-Specific Perforin and Granzyme B ELISPOT Assays Detect Reactivation of CMV Infection in Inflammatory Bowel Disease by Paul V. Lehmann, Jan Heidemann, Matthias Ross, Dominik Bettenworth, Tobias M. Nowacki, Andreas Lügering

“…Typically, the CMV genome remains dormant in infected cells, but a breakdown of immune surveillance can lead to re-activation of viral replication in the gut mucosa, which is not necessarily associated with viremia or changes in antibody titers. …”
Get full text

Theoretical advances toward understanding recent experiments in biophysical chemistry by Zimanyi, Eric Norman

Get full text

Tumour catabolism independent of malnutrition and inflammation in upper GI cancer patients revealed by longitudinal metabolomics by Janusz vonRenesse, Felix vonBechtolsheim, Sophie Jonas, Lena Seifert, Tiago C. Alves, Adrian M. Seifert, Filip Komorek, Guergana Tritchkova, Mario Menschikowski, Ulrich Bork, Ronny Meisterfeld, Marius Distler, Triantafyllos Chavakis, Jürgen Weitz, Alexander M. Funk, Christoph Kahlert, Peter Mirtschink

“…Increased glycerol levels (P < 0.0001), increased concentration of the ketogenic amino acid lysine (P = 0.03) and a significant correlation of 3‐hydroxybutyrate levels with branched‐chained amino acids (leucine, P = 0.02; isoleucine, P = 0.04 [FDR adjusted]) suggested that ketone body synthesis was driven by lipolysis and amino acid breakdown. Interestingly, the catabolic signature was independent of the body mass index, clinically assessed malnutrition using the nutritional risk screening score, and systemic inflammation assessed by CRP and leukocyte count. …”
Get full text

Studies of traps in AlGaN/GaN high electron mobility transistors on silicon by Anand Mulagumoottil Jesudas

“…Subsequently, we have enhanced the device breakdown voltage by at least two times as compared to the non BCB encapsulated HEMTs. …”
Get full text

Methods of analyzing and assessing economic and financial risks by Valentin SAVA, Manuela-Violeta TUREATCA, Daniela Ludmila MANEA

“…The third section presents the ways to analyze and evaluate risks, emphasizes the role of the critical matrix, and reviews the most commonly used risk assessment methods: Osborn Brainstorming, Delphi, Abaque de Régnier, BISF method (breakdowns, the importance of the equipment, the state of the process and its function, RCM (reliability centered maintenance), Ishikiwa. …”
Get full text

Energy Autonomous Wireless Sensor Nodes for Freight Train Braking Systems Monitoring by Federico Zanelli, Marco Mauri, Francesco Castelli-Dezza, Edoardo Sabbioni, Davide Tarsitano, Nicola Debattisti

“…Implementing a real time monitoring of the main components and a predictive maintenance approach, it would be possible to avoid unexpected breakdowns and consequently unavailability of wagons for unscheduled repair activities. …”
Get full text

Characterisation and modelling of pedestrian flows in hospital and academic environments by Alhassan, Hashim Mohammed, Mashros, Nordiana

“…The modelling effort showed that the free walking speed in the university environment was 68.052 m/min with a critical density of 3.15 ped/m2. That of the hospital environment was 75.099 m/min and a critical density of 4.36 ped/m2. …”
Get full text

Prophets Without Honor: From Galileo to Looney by Bob Meyers

“…He was ridiculed for going against received medical practice and committed to an asylum by colleagues after supposedly suffering a nervous breakdown. There he was beaten by guards and died from an untreated gangrenous wound. …”
Get full text

Gendered impacts of the war in Ukraine: identifying potential, presumed or actual women victims of trafficking at the Italian borders by Francesca Cimino, Paola Degani

“…It is well-known that human trafficking tends to increase during conflicts and humanitarian crises due to the spread of impunity, destruction of institutions, and breakdown of law. The EU and many international organizations have warned those fleeing Ukraine about the high risk of trafficking and adopted policies to prevent and detect trafficking. …”
Get full text

Long-term administration of intravenous Trappsol® Cyclo™ (HP-β-CD) results in clinical benefits and stabilization or slowing of disease progression in patients with Niemann-Pick di... by Reena Sharma, Caroline Hastings, Orna Staretz-Chacham, Julian Raiman, Martin Paucar, Ronen Spiegel, Bryan Murray, Bryan Hurst, Benny Liu, Lise Kjems, Sharon Hrynkow

“…Preclinical studies confirmed a critical role of systemically administered hydroxypropyl-β-cyclodextrin (HP-β-CD; Trappsol® Cyclo™) in cholesterol metabolism and homeostasis in peripheral tissues of the body, including the liver, and in the central nervous system (CNS). …”
Get full text

Quasi electrical contact behaviors of metal micro-contacts for micro/nano-electromechanical systems (MEMS/NEMS) by Qiu, Haodong

“…A geometrical picture could be used to describe the breakdown of the insulating alien film, in which the stable electrical contact is eventually established by overlapping “weak” spots that form a percolation path between the micro-contacts. …”
Get full text

Toward Smart Condition Monitoring of Rotatory Machines: An Optimized Probabilistic Signal Reconstruction Methodology for Fault Prediction With Multisource Uncertainties by Xiaomo Jiang, Weijian Tang, Haixin Zhao, Xueyu Cheng

“…Faults in the critical components of a large rotatory machine often result in unplanned breakdowns, leading to a significant loss of property and life. …”
Get full text

The risks you can’t foresee: what to do when there’s no playbook by Kaplan, RS, Leonard, HBD, Mikes, A

“…Some result from a perfect storm of coinciding breakdowns, and some materialize very rapidly and on an enormous scale. …”

Evidence for ground state coherence in a two-dimensional Kondo lattice by Wen Wan, Rishav Harsh, Antonella Meninno, Paul Dreher, Sandra Sajan, Haojie Guo, Ion Errea, Fernando de Juan, Miguel M. Ugeda

“…The manifestation of magnetic coherence in TMD-based 2D Kondo lattices enables the exploration of magnetic quantum criticality, Kondo breakdown transitions and unconventional superconductivity in the strict two-dimensional limit.…”
Get full text

Interfacial Fluid Dynamics in Porous Media by Primkulov, Bauyrzhan K.

“…These patterns can be reminiscent of dielectric breakdown, diffusion-limited growth of crystals, or percolation clusters in polymer gelation, depending on the relative affinity of the two fluids to the porous medium (wettability) and the balance of viscous and capillary forces. …”
Get full text
Get full text

Electrolyte reactivity at the charged Ni-rich cathode interface and degradation in Li-ion batteries by Dose, WM, Temprano, I, Allen, JP, Björklund, E, O’Keefe, CA, Li, W, Mehdi, BL, Weatherup, RS, De Volder, MFL, Grey, CP

“…Higher lattice oxygen release with EC-containing electrolytes is coupled with higher cathode interfacial impedance, a thicker oxygen-deficient rock-salt surface reconstruction layer, more electrolyte solvent and salt breakdown, and higher amounts of transition metal dissolution. …”

Motor operation condition monitoring by accelerometer by Ong, Celeste Jia Yi

“…As a result, unwanted breakdowns and downtime are avoided, and the lifetime of machines is extended. …”
Get full text

Allowing temporary access to real property for maintenance of technical infrastructure by Mirosław Gdesz

“…The article indicates that maintenance and repair of public infrastructure breakdowns should come under the content of the ownership title, without the need for individual restriction of ownership rights. …”
Get full text

Investigation of the Migration, Distribution, and Influence of Microplastic Leakage on Tuanjishan Island in Zhoushan Using Mike by Yan LI, Lu CAO, Jiayin BIAN, Wei CHEN, Zequan LENG, Xizeng ZHAO, Yun GAO

“…The intricate landfill milieu, characterized by high salinity, fluctuating temperatures and pH, gas emissions, physical pressure, and biodegradation, fosters the breakdown of plastic waste, leading to MP production. …”
Get full text

Advanced CMOS technologies (high-k/metal gate stacks) for sub-22nm node by Wu, Ling

“…Electrical and Physical Properties of Er doped HfO2 high-k dielectrics prepared by Atomic Layer Deposition A metal gate/Hf-based high-k dielectric gate stack with an appropriate work function is considered as one of the critical technology solutions for sub-45 nm complementary metal oxide semiconductor technology. …”
Get full text