Examining the U-shaped relationship of sleep duration and systolic blood pressure with risk of cardiovascular events using a novel recursive gradient scanning model by Shuo Yang, Nanxiang Zhang, Zichao Liang, Yuduan Han, Hao Luo, Yingfeng Ge, Jianan Yin, Chonglong Ding, Chao Li, Qitong Zhang, Jinxin Zhang

“…The maximum equal-odds ratio (OR) method was implemented to obtain optimal cut-points for each continuous independent variable. Then, a novel “recursive gradient scanning method” was introduced for discretizing multiple non-monotonic U-shaped independent variables. …”
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Efficacy and safety of a novel pain management device, AT-04, for endometriosis-related pain: study protocol for a phase III randomized controlled trial by Hiroshi Ishikawa, Osamu Yoshino, Fuminori Taniguchi, Tasuku Harada, Mikio Momoeda, Yutaka Osuga, Tamiki Hikake, Youko Hattori, Michiko Hanawa, Yosuke Inaba, Hideki Hanaoka, Kaori Koga

“…Discussion This study aims to develop a novel method of managing endometriosis-related pain. …”
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Diagnosis of Newly Delivered Mothers for Periodontitis with a Novel Oral-Rinse aMMP-8 Point-of-Care Test in a Rural Malawian Population by Jussi M. Leppilahti, Ulla Harjunmaa, Jorma Järnstedt, Charles Mangani, Marcela Hernández, Taina Tervahartiala, Rodrigo Lopez, Ulla Ashorn, Per Ashorn, Dirk-Rolf Gieselmann, Timo Sorsa

“…A novel qualitative point-of-care test of activated matrix metalloproteinase-8 (aMMP-8) using noninvasive oral rinse sampling procedures has been developed for the early detection of collagen breakdown indicating periodontal tissue destruction. …”
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A Novel Urine Exosomal lncRNA Assay to Improve the Detection of Prostate Cancer at Initial Biopsy: A Retrospective Multicenter Diagnostic Feasibility Study by Yun Li, Jin Ji, Ji Lyu, Xin Jin, Xing He, Shaojia Mo, Huan Xu, Jingyi He, Zhi Cao, Xi Chen, Yalong Xu, Lei Wang, Fubo Wang

“…Purpose: This study aimed at developing and validating a novel noninvasive urinary exosome-based post-DRE (digital rectal examination) lncRNA assay to diagnose PCa (prostate cancer) and clinically significant PCa (Gleason score ≥ 7) from the initial prostate biopsy. …”
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Phase I trial of KN046, a novel bispecific antibody targeting PD-L1 and CTLA-4 in patients with advanced solid tumors by Yang Zhang, Yan Huang, Li Zhang, Jie Sun, Hongyun Zhao, Yunpeng Yang, Wenfeng Fang, Yuanyuan Zhao, Yuxiang Ma, Qun Li, Ye Guo, Yuhan Zhang, Jinhui Xue, Xiaoxiao Ge, Bangyong Zhang, Jinyuan Xiao

“…Background KN046 is a novel bispecific antibody targeting programmed death ligand 1 (PD-L1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4). …”
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Novel Framework (Target Trial Emulation) in Observational Causal Inference Research Based on Real-world Data and Its Application Prospects in Traditional Chinese Medicine by LU Cuncun, CHEN Zijia, WANG Zhifei

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Novel Approaches for the Treatment of Post-Traumatic Stress Disorder: A Systematic Review of Non-Invasive Brain Stimulation Interventions and Insights from Clinical Trials by Daniele Saccenti, Leandro Lodi, Andrea Stefano Moro, Simona Scaini, Barbara Forresi, Jacopo Lamanna, Mattia Ferro

“…However, many patients fail to respond to such interventions, highlighting the need for novel approaches. Due to its ability to modulate cortical activity, non-invasive brain stimulation (NIBS) could represent a valuable therapeutic tool. …”
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A meta-analysis on first-trimester blood count parameters—is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening? by Balázs Mészáros, Dániel S. Veres, Luca Nagyistók, Bence G. Kovács, Zoltán Kukor, Sándor Valent

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A novel approach to conducting clinical trials in the community setting: utilizing patient-driven platforms and social media to drive web-based patient recruitment by Janelle Applequist, Cristina Burroughs, Artemio Ramirez, Peter A. Merkel, Marc E. Rothenberg, Bruce Trapnell, Robert J. Desnick, Mustafa Sahin, Jeffrey P. Krischer

“…Abstract Background Participant recruitment for clinical research studies remains a significant challenge for researchers. Novel approaches to recruitment are necessary to ensure that populations are easier to reach. …”
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Real-world post-deployment performance of a novel machine learning-based digital health technology for skin lesion assessment and suggestions for post-market surveillance by Lucy Thomas, Chris Hyde, Dan Mullarkey, Jack Greenhalgh, Dilraj Kalsi, Justin Ko

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Performance of fecal S100A12 as a novel non-invasive diagnostic biomarker for pediatric inflammatory bowel disease: a systematic review and meta-analysis by Bendix Samarta Witarto, Visuddho Visuddho, Andro Pramana Witarto, Mahendra Tri Arif Sampurna, Abyan Irzaldy

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Feasibility of a Novel COVID-19 Telehealth Care Management Program Among Individuals Receiving Treatment for Opioid Use Disorder: Analysis of a Pilot Program by Kimberly D Williams, Claudine T Jurkovitz, Mia A Papas, Ann Kathryn Muther, Sharon L Anderson, Tammy L Anderson

“…ConclusionsThese results demonstrate the feasibility of a novel telehealth intervention to monitor COVID-19 symptoms among OTP patients in treatment for OUD. …”
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Efficacy and Adherence Rates of a Novel Community‐Informed Virtual World‐Based Cardiac Rehabilitation Program: Protocol for the Destination Cardiac Rehab Randomized Controlled Tria... by LaPrincess C. Brewer, Helayna Abraham, Donald Clark, Melvin Echols, Michael Hall, Karen Hodgman, Brian Kaihoi, Stephen Kopecky, Ashton Krogman, Shawn Leth, Shaista Malik, Jill Marsteller, Lena Mathews, Robert Scales, Phillip Schulte, Adam Shultz, Bryan Taylor, Randal Thomas, Nathan Wong, Thomas Olson

“…Destination Cardiac Rehab is a novel virtual world technology‐based CR program delivered through the virtual world platform, Second Life, which previously demonstrated high acceptability as an extension of traditional center‐based CR. …”
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A pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychop... by Simone Cheli, Veronica Cavalletti, Paul H. Lysaker, Giancarlo Dimaggio, Nicola Petrocchi, Francesca Chiarello, Consuelo Enzo, Francesco Velicogna, Francesco Mancini, Gil Goldzweig

“…This pilot non-inferiority randomized controlled trial aimed to compare a novel form of psychotherapy tailored for this disorder and a combination of cognitive therapy and psychopharmacological treatment. …”
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Identifying neonates at risk for post-discharge mortality in Dar es Salaam, Tanzania, and Monrovia, Liberia: Derivation and internal validation of a novel risk assessment tool by Robert F Breiman, Christopher R Sudfeld, Rodrick Kisenge, Christopher P Duggan, Cynthia G Whitney, Claudia R Morris, Chris A Rees, Readon C Ideh, Michelle Niescierenko, Karim P Manji, Julia Kamara, Abraham Samma, Evance Godfrey, Hussein K Manji, Adrianna L Westbrook, Ye-Jeung G Coleman-Nekar

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Assessment of geriatric and clinical domains for development and validation of a novel nomogram to predict the prognosis of older patients with breast cancer: a real-world retrospe... by Yan Lin, Yu Song, Ying Xu, Changjun Wang, Yali Xu, Xin Huang, Qiang Sun

“…Moreover, the calibration curve and DCA revealed good predictive accuracy between the actual and predicted probabilities.ConclusionIndependent prognostic factors for OS and BCSS in older patients with breast cancer in China were determined in our study. A novel nomogram for predicting the 1-, 3-, and 5-year OS and BCSS in this patient population was developed and validated. …”
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<i>RPE65</i> c.353G>A, p.(Arg118Lys): A Novel Point Mutation Associated with Retinitis Pigmentosa and Macular Atrophy by Mirjana Bjeloš, Mladen Bušić, Ana Ćurić, Borna Šarić, Damir Bosnar, Leon Marković, Biljana Kuzmanović Elabjer, Benedict Rak

“…This case report aims to report a novel RP-related point mutation <i>RPE65</i> c.353G>A, p.…”
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Covariates Relating to Implant Failure and Marginal Bone Loss of a Novel Triangular Neck-Implant Placed by Post-Graduate Students: A 1-Year Prospective Cohort Study by Maria Giralt-Hernando, Gian Maria Ragucci, Oriol Cantó-Naves, Adaia Valls-Ontañón, Federico Hernández-Alfaro

“…The purpose of this study was to identify contributing covariates to implant failure and marginal bone loss (MBL) at the 1-year follow-up of a novel triangular-neck implant design when placed by inexperienced post-graduate students. (2) Methods: A prospective cohort study was conducted on study participants eligible for implant placement at the UIC (International University of Catalonia), Barcelona, Spain. …”
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Novel breath-hold liver target stereotactic ablative radiotherapy using the intrafraction diaphragm registration of kilovoltage projection streaming image with digitally reconstruc... by Atsuto Katano, Yuki Nozawa, Masanari Minamitani, Hideomi Yamashita, Keiichi Nakagawa

“…Stereotactic ablative radiotherapy (SABR) is an emerging treatment option for patients with primary or metastatic liver tumors, particularly for those who are not eligible for surgery or transplantation. SABR is a high-precision radiation therapy that delivers a high dose of radiation to the tumor while minimizing the dose to the surrounding healthy tissues. …”
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Future Innovations in Novel Detection for Atrial Fibrillation (FIND-AF): pilot study of an electronic health record machine learning algorithm-guided intervention to identify undia... by Gregory Y H Lip, Chris P Gale, Jianhua Wu, Ramesh Nadarajah, Catherine Reynolds, David Hogg, Ali Wahab, John Keene, Campbel Cowan, Keerthenan Raveendra, Deborah Askham, Richard Dawson, Sagar Shanghavi

“…A machine learning algorithm (Future Innovations in Novel Detection of Atrial Fibrillation (FIND-AF)) developed to predict incident AF within 6 months using data in primary care electronic health records (EHRs) could be used to guide AF screening. …”
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