The Feasibility of Whole-Liver Drainage with a Novel 8 mm Fully Covered Self-Expandable Metal Stent Possessing an Ultra-Slim Introducer for Malignant Hilar Biliary Obstructions by Saburo Matsubara, Keito Nakagawa, Kentaro Suda, Takeshi Otsuka, Masashi Oka, Sumiko Nagoshi

“…In this article, the results of whole-liver drainage tests using this novel FCSEMS for MHBO are reported. Methods: Unresectable MHBOs up to Bismuth IIIa with strictures limited to the secondary branches were eligible. …”
Get full text

A novel curriculum for the Same-Sex Marriage Act and Patient Right to Autonomy Act (SMPRA) module based on two new laws in Taiwan: a mixed-methods study by Yi-Chih Shiao, Zxy-Yann Jane Lu, Chung-Pei Fu, Jing-Yi Lin, Yaw-Wen Chang, Wan-Ting Chen, Chih-Chia Wang

Get full text

Red Cell Distribution Width-to-High-Density Lipoprotein Cholesterol Ratio (RHR): A Promising Novel Predictor for Preoperative Deep Vein Thrombosis in Geriatric Patients with Hip Fr... by Cheng X, Fan L, Hao J, He H, Yan J, Zhu Y

Get full text

Construction and validation of a novel prognostic model for intrahepatic cholangiocarcinoma based on a combined scoring system of systemic immune-inflammation index and albumin-bil... by Haofeng Zhang, Haofeng Zhang, Qingshan Li, Qingshan Li, Guan Huang, Guan Huang, Zhenwei Yang, Kunlun Chen, Bo Meng, Haibo Yu, Haibo Yu

“…Evaluation of the model’s predictive strength was performed through ROC survival curves and calibration curves in the training set and validation set, revealing favorable predictive performance.ConclusionThe SII+ALBI grade, a novel classification based on inflammatory and immune status, serves as a reliable prognostic indicator for postoperative OS and RFS in patients with ICC.…”
Get full text

Phase I dose escalation study and pilot efficacy analysis of LXI-15029, a novel mTOR dual inhibitor, in Chinese subjects with advanced malignant solid tumors by Jiani Wang, Lin Gui, Yuxin Mu, Jiayu Wang, Yihebali Chi, Zhenteng Liu, Qing Li, Binghe Xu

Get full text

Final 36-Month Outcomes from the Multicenter DynamX Study Evaluating a Novel Thin-Strut Novolimus-Eluting Coronary Bioadaptor System and Supporting Preclinical Data by Stefan Verheye, Mathias Vrolix, Matteo Montorfano, Francesco Giannini, Francesco Bedogni, Christophe Dubois, Bernard De Bruyne, Ricardo A. Costa, Daniel Chamié, José Ribamar Costa Jr, Alexandre Abizaid, Antonio Colombo

Get full text

Tumor Area Positivity (TAP) score of programmed death-ligand 1 (PD-L1): a novel visual estimation method for combined tumor cell and immune cell scoring by Chunyan Liu, Fang Fang, Ying Kong, Ehab A. ElGabry

“…In this study, we introduce the Tumor Area Positivity (TAP) score, which is a novel, straightforward method for scoring tumor cells and immune cells together using visual estimation. …”
Get full text

Adjunct role of potassium-rich vegetarian diet and a novel potassium food supplement to improve pain in chronic rheumatoid arthritis on supervised standard care: a randomised contr... by Arvind Chopra, Manjit Saluja, Toktam Kianifard, Sanjeev Sarmukaddam, Anuradha Venugopalan

“…Introduction An earlier food survey showed dietary potassium deficiency in rheumatoid arthritis (RA).Objective To evaluate an adjunct role of oral potassium to reduce joint pain in RA.Methods 172 consenting eligible symptomatic patients (median duration 6.5 years) on standard care were randomised into an assessor blind, parallel efficacy, controlled, prospective, multiarm single-centre study (80% power, drug trial design) of 16 weeks duration—arm A (potassium-rich vegetarian diet), arm B (arm A plus novel potassium food supplement) and arm C (control, regular diet). …”
Get full text

A novel therapeutic management for diabetes patients with chronic limb-threatening ischemia: comparison of autologous bone marrow mononuclear cells versus allogenic Wharton jelly-d... by Martha L. Arango-Rodríguez, Ligia C. Mateus, Claudia L. Sossa, Silvia M. Becerra-Bayona, Víctor Alfonso Solarte-David, Miguel Enrique Ochoa Vera, Lady T. Giratá Viviescas, Ana M. Vera Berrio, Sergio Eduardo Serrano, Oliverio Vargas, Andrés Catalá Isla, Alape Benitez, Germán Rangel

Get full text

Efficacy and feasibility of Apatinib and S-1 as a novel oral induction therapy in locally advanced head and neck squamous cell carcinoma: an exploratory phase 2 open-label, single-... by Wen Jiang, Rongrong Li, Lin Zhang, Shengjin Dou, Lulu Ye, Ziyang Shao, Sicheng Wu, Minjun Dong, Jiang Li, Guopei Zhu

“…We conducted a clinical study to explore the efficacy and feasibility of a novel induction therapy with orally administered apatinib and S-1 in LA-HNSCC.Materials and methodsThis nonrandomized, single-arm, prospective clinical trial included patients with LA-HNSCCs. …”
Get full text

Serum immune mediators as novel predictors of response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients with high tissue-PD-L1 expression by Afsheen Raza, Afsheen Raza, Reyad Mohsen, Aladdin Kanbour, Abdul Rehman Zar Gul, Anite Philip, Suma Vijayakumar, Shereena Hydrose, Shereena Hydrose, Kirti S. Prabhu, Aisha Khamis Al-Suwaidi, Aisha Khamis Al-Suwaidi, Varghese Philipose Inchakalody, Varghese Philipose Inchakalody, Maysaloun Merhi, Maysaloun Merhi, Dina M. Abo El-Ella, Dina M. Abo El-Ella, Melissa Annrose Tauro, Shayista Akbar, Issam Al-Bozom, Wafa Abualainin, Rajaa Al-Abdulla, Shaza Abu Sirriya, Suparna Hassnad, Shahab Uddin, Shahab Uddin, Mohamed Izham Mohamed Ibrahim, Ussama Al Homsi, Said Demime, Said Demime, Said Demime

“…Sera from 31 metastatic NSCLC patients, eligible for anti-PD-1/PD-L1 or combined chemoimmunotherapy, were collected prior to treatment. …”
Get full text

Novel care pathway to optimise antimicrobial prescribing for uncomplicated community-acquired pneumonia: study protocol for a prospective before–after cohort study in the emergency... by Lehana Thabane, Marek Smieja, Mark Loeb, Jeffrey M Pernica, Dominik Mertz, April J Kam, David M Goldfarb, Jacqueline Wong, Sarah Khan, Fiona Smaill, Melani Sung, Mohamed Eltorki, Joycelyne Ewusie

“…In the intervention (after) phase, eligible participants will be managed as per the novel care pathway. …”
Get full text

Safety and Immunogenicity of a novel three-dose recombinant nanoparticle rabies G protein vaccine administered as simulated post exposure immunization: A randomized, comparator con... by Ravish H S, Akash Khobragade, Durga Satapathy, Monica Gupta, Surendra Kumar, Vinay Bhomia, Ramasubramanian V, Maharshi Desai, Ashok Dilipkumar Agrawal

“…Objectives To establish a noninferiority of a novel three-dose recombinant rabies G protein vaccine to be administered as simulated postexposure prophylaxis when compared to five-dose WHO prequalified vaccine for better safety and immunogenicity. …”
Get full text

The impact of not having a primary care provider on emergency department utilization and hospitalizations before and during COVID-19: A novel retrospective cohort study linking pri... by Emily Gard Marshall, David Stock, Richard Buote

“…During the study period, 100,867 primary care-eligible Nova Scotians (10.1% of the population) were on the waitlist. …”
Get full text

Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-lab... by Graham McIlroy, Siân Lax, Charlotte Gaskell, Aimee Jackson, Malcolm Rhodes, Tania Seale, Sonia Fox, Lousie Hopkins, Jessica Okosun, Sally F. Barrington, Ingo Ringshausen, Alan G. Ramsay, Maria Calaminici, Kim Linton, Mark Bishton

“…Methods The REFRACT trial is an investigator-initiated, UK National Cancer Research Institute, open-label, multi-centre, randomised phase II platform trial aimed at accelerating clinical development of novel therapies by addressing evidence gaps. The first of the three sequential novel therapy arms is epcoritamab plus lenalidomide, to be compared with investigator choice standard therapy (ICT). …”
Get full text

A Novel Functional Refined Olive Oil, Enhanced with Orange Peel Extract, Modulates Postprandial LDL-Cholesterol Responses in Individuals at Cardiometabolic Risk: A Pilot Randomized... by Olga Papagianni, Chrysoula Kaloteraki, Aikaterini Kandyliari, Panagiota Potsaki, Panorea Bousdouni, Kalliopi Almpounioti, Camille Ouzaid, Anna-Kyriaki Mavrou, Vasiliki Panteli, Thomas Loukas, Athanasios Magkoutis, Dimitrios Skalkos, Haralabos C. Karantonis, Antonios E. Koutelidakis

Get full text

AK112, a novel PD-1/VEGF bispecific antibody, in combination with chemotherapy in patients with advanced non-small cell lung cancer (NSCLC): an open-label, multicenter, phase II tr... by Yuanyuan Zhao, Gang Chen, Jianhua Chen, Li Zhuang, Yingying Du, Qitao Yu, Wu Zhuang, Yanqiu Zhao, Ming Zhou, Weidong Zhang, Yu Zhang, Yixin Wan, Wenting Li, Weifeng Song, Zhongmin Maxwell Wang, Baiyong Li, Michelle Xia, Yunpeng Yang, Wenfeng Fang, Yan Huang, Li Zhang

Get full text

Does Therapy with Glucagon-like Peptide 1 Receptor Agonists Have an Effect on Biochemical Markers of Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD)? Pleiotropic M... by Marcin Hachuła, Michał Kosowski, Marcin Basiak, Bogusław Okopień

Get full text

An efficacy and safety report based on randomized controlled single-blinded multi-centre clinical trial of ZingiVir-H, a novel herbo-mineral formulation designed as an add-on thera... by Shan Sasidharan, Hareendran Nair J, Srinivasakumar K P, Jerin Paul, Madhu Kumar R, Kannan Rajendran, Anita Ajit Saibannavar, Sonali Nirali

Get full text

An efficacy and safety report based on randomized controlled single-blinded multi-centre clinical trial of ZingiVir-H, a novel herbo-mineral formulation designed as an add-on thera... by Shan Sasidharan, Hareendran Nair J., Srinivasakumar K. P., Jerin Paul, Madhu Kumar R., Kannan Rajendran, Anita Ajit Saibannavar, Sonali Nirali

Get full text