The Emerging Role of miRNAs for the Radiation Treatment of Pancreatic Cancer by Lily Nguyen, Daniela Schilling, Sophie Dobiasch, Susanne Raulefs, Marina Santiago Franco, Dominik Buschmann, Michael W. Pfaffl, Thomas E. Schmid, Stephanie E. Combs

“…Only 15–20% of patients are eligible for curative intent surgery at the time of diagnosis. …”
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Systematic reviews on the prognostic role of biomarkers in heart failure by Vazquez-Montes, M, Kadoglou, N, Roberts, N, Collins, G, Perera, R, Altman, D, Hobbs, R, Taylor, C, Dhiman, P, Moons, K, DeBray, T, Parissis, J, Trivella, M

“…We aim to test this hypothesis through a systematic reviews series assessing the evidence of HF prognostic models using novel meta-analysis (MA) methodology and relevant critical appraisal tools. …”

Repeat Ivermectin Mass Drug Administrations for Malaria Control II: Protocol for a Double-blind, Cluster-Randomized, Placebo-Controlled Trial for the Integrated Control of Malaria by Brian D Foy, Anthony Some, Tereza Magalhaes, Lyndsey Gray, Sangeeta Rao, Emmanuel Sougue, Conner L Jackson, John Kittelson, Hannah C Slater, Teun Bousema, Ollo Da, A Gafar V Coulidiaty, McKenzie Colt, Martina Wade, Kacey Richards, A Fabrice Some, Roch K Dabire, Sunil Parikh

“…Nonpregnant individuals >90 cm in height were eligible for ivermectin MDA, and cotreatment with ivermectin and SMC was not permitted. …”
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Investigating the role of the endocannabinoid system and gut-microbiome in psychotic and severe mental illness: a focus on negative symptoms by Minichino, A

“…Pooled results from 5 eligible randomised controlled trials showed that metformin has pro-cognitive effects, with preliminary evidence showing efficacy on negative symptoms. …”

Predictive model for treatment outcomes of peripheral T-cell lymphoma, not otherwise specified, in Taiwanese patients by Ning-Chun Chen, Hung Chang, Ming-Chung Kuo, Tung-Liang Lin, Lee-Yung Shih, Wen-Yu Chuang, Hsiao-Wen Kao

“…The usefulness of the novel prognostic index for PTCL-NOS needs further validation.…”
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An Intensive Ambulatory Care Program for Adolescents With Eating Disorders Combining In-Person and Web-Based Care: Protocol for a Single-Site Naturalistic Trial by Kaylee Novack, Rachel Dufour, Louis Picard, Linda Booij, Nicholas Chadi

“…ObjectiveWe aimed to implement a novel hybrid (web-based and in-person) intensive ambulatory care program for youth and evaluate its feasibility, acceptability, and preliminary effectiveness. …”
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Design of Two Phase III, Randomized, Multicenter Studies Comparing Gepotidacin with Nitrofurantoin for the Treatment of Uncomplicated Urinary Tract Infection in Female Participants by Caroline Perry, Mohammad Hossain, Marcy Powell, Aparna Raychaudhuri, Nicole Scangarella-Oman, Courtney Tiffany, Sherry Xu, Etienne Dumont, Salim Janmohamed

“…Treatment options are increasingly limited by antibiotic resistance; novel oral antibiotics are urgently needed. Gepotidacin is a novel, bactericidal, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial deoxyribonucleic acid (DNA) replication by a distinct mechanism of action, which confers activity against most strains of target pathogens, such as Escherichia coli and Staphylococcus saprophyticus, including those resistant to current antibiotics. …”
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Advanced Heart Failure: Therapeutic Options and Challenges in the Evolving Field of Left Ventricular Assist Devices by Michael Antonopoulos, Michael J. Bonios, Stavros Dimopoulos, Evangelos Leontiadis, Aggeliki Gouziouta, Nektarios Kogerakis, Antigone Koliopoulou, Dimitris Elaiopoulos, Ioannis Vlahodimitris, Maria Chronaki, Themistocles Chamogeorgakis, Stavros G. Drakos, Stamatis Adamopoulos

“…Improved outcomes have been achieved with novel drugs and devices. However, the number of patients refractory to conventional medical therapy is growing. …”
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A Narrative Review Discussing the Obstetric Repercussions Due to Alterations of Personalized Bacterial Sites Developed within the Vagina, Cervix, and Endometrium by Bogdan Doroftei, Ovidiu-Dumitru Ilie, Theodora Armeanu, Irina-Liviana Stoian, Nicoleta Anton, Ramona-Geanina Babici, Ciprian Ilea

“…Background: The reproductive tract microbiota that evolved as an integrative component has been studied intensively in the last decade. As a result, novel research, clinical opportunities, and perspectives have been derived following the close investigation of this microecological environment. …”
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Protocol for the promoting resilience in stress management (PRISM) intervention: a multi-site randomized controlled trial for adolescents and young adults with advanced cancer by Alison O’Daffer, Liam Comiskey, Samantha R. Scott, Chuan Zhou, Miranda C. Bradford, Joyce P. Yi-Frazier, Abby R. Rosenberg

“…Discussion This study will provide methodologically rigorous data and evidence regarding a novel intervention to promote resilience and reduce distress among AYAs with advanced cancer. …”
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The effect of transcranial direct current stimulation (tDCS) on cognitive function recovery in patients with depression following electroconvulsive therapy (ECT): protocol for a ra... by Renqin Hu, Junyao Li, Yulin Lu, Huirong Luo, Yinlin Zhang, Xueqian Wang, Zheng Zhang, Qinghua Luo

“…Discussion We describe a novel clinical trial to explore whether the administration of tDCS after completing ECT course can accelerates recovery from the CSEs. …”
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Timing, Indicators, and Approaches to Digital Patient Experience Evaluation: Umbrella Systematic Review by Tingting Wang, Guido Giunti, Richard Goossens, Marijke Melles

“…Overall, 38% (45/119) of the articles were considered eligible for further thematic analysis. In phase 2, to check if there were any meaningful novel insights that would change our conclusions, we performed an updated literature search in which we collected 294 newly published reviews, of which 102 (34.7%) were identified as eligible articles. …”
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203 Implementing a hospital-based referral system to connect heart failure patients with payer disease management: approaches and lessons from a pilot study by Mark E. Patterson, Paul Chan, Susan Melton, Tracie Breeding, Stacy Farr, John Spertus

“…To overcome gaps in connecting patients hospitalized with heart failure to DM, we implemented a novel warm handoff referral between hospital providers and payer DM using the Implementation Research Logic Model (IRLM). …”
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Trusted residents and housing assistance to decrease violence exposure in New Haven (TRUE HAVEN): a strengths-based and community-driven stepped-wedge intervention to reduce gun vi... by Guangyu Tong, Virginia T. Spell, Nadine Horton, Thomas Thornhill, Danya Keene, Christine Montgomery, Donna Spiegelman, Emily A. Wang, Brita Roy

“…Discussion Results from this protocol will yield novel evidence for whether and how addressing structural racism citywide leads to a reduction in gun violence. …”
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Effect of patient-delivered household contact tracing and prevention for tuberculosis: a household cluster-randomised trial in Malawi by Kaswaswa, K, MacPherson, P, Kumwenda, M, Mpunga, J, Thindwa, D, Nliwasa, M, Mwapasa, M, Odland, J, Tomoka, T, Chipungu, G, Mukaka, M, Corbett, EL

“…However, it is resource intensive, inconvenient, and often poorly implemented. We investigated a novel model aiming to improve uptake.<br><br> <strong>Methods</strong><br> Between May and December 2014, we randomised patient with TB who consented to participate in the trial to either standard of care (SOC) or intervention (PACTS) arms. …”

The Role of Pharmacotherapy in Treatment of Meningioma: A Systematic Review by Ataollah Shahbandi, Darsh S. Shah, Caroline C. Hadley, Akash J. Patel

“…Several promising targeted agents have been developed and are currently being investigated in the hope of identifying novel therapeutic strategies for the treatment of this pathology.…”
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Use of complete medication history to identify and correct transitions-of-care medication errors at psychiatric hospital admission. by Victoria Vargas, Weston W Blakeslee, Colin A Banas, Christian Teter, Katherine Dupuis-Dobson, Carol Aboud

“…All medication errors that were reported by pharmacy staff in the admission medication reconciliation process during a period of 6 months were eligible for inclusion. Complete medication history data source was utilized by admitting providers and all pharmacist staff and a novel medication error scoring methodology was developed. …”
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Preliminary experience with recanalization of large vessel occlusion due to underlying long-segment dissection using a standby microwire technique by Xiaoxi Zhang, Hongye Xu, Zhengzhe Feng, Weilong Hua, Hongjian Shen, Lei Zhang, Yongxin Zhang, Pengfei Xing, Pengfei Yang, Xiaolong Xu, Zifu Li

“…PurposeThis study aimed at investigating a novel standby microwire technique to facilitate revascularization of large vessel occlusion due to underlying long-segment dissection.MethodsPatients with acute ischemic stroke with emergent large vessel occlusion (ELVO) due to underlying long-segment dissection were screened from the prospectively established database between January 2021 and May 2022. …”
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Modern Kidney-Sparing Management of Upper Tract Urothelial Carcinoma by Alireza Ghoreifi, Reza Sari Motlagh, Gerhard Fuchs

“…Data from retrospective studies support the superiority of this approach over radical treatment with similar oncological outcomes, albeit in select cases. Novel chemoablation agents have also been studied in the past few years, of which mitomycin gel has received FDA approval for use in low-risk UTUCs. …”
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An Efficient Document Skew Detection Method Using Probability Model and <i>Q</i> Test by Kai Huang, Zixuan Chen, Min Yu, Xiaolang Yan, Aiguo Yin

“…To achieve a good tradeoff between efficiency and performance, we propose a novel skew detection approach based on bounding boxes, probability model, and Dixon&#8217;s <b><i>Q</i></b> test. …”
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