Summary of biological research on hepatoblastoma: a scoping review by Huan-sheng Wang, Jing Lao, Ren-sen Jiang, Bin Wang, Xiao-peng Ma, Jian-yao Wang

“…Our review aims to facilitate the exploration of novel molecular mechanisms and the development of innovative clinical treatment strategies for hepatoblastoma.…”
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A Robust Document Identification Framework through f-BP Fingerprint by Francesco Guarnera, Oliver Giudice, Dario Allegra, Filippo Stanco, Sebastiano Battiato, Salvatore Livatino, Vito Matranga, Angelo Salici

“…To validate the robustness of the proposed method, a novel dataset was created and recognition tests were performed under both ideal and noisy conditions.…”
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Cell therapies for autism spectrum disorder: a systematic review of clinical applications by Ayberk Akat, Erdal Karaöz

“…Conclusion Overall, the evidence suggests that various cell therapy methods may offer a novel and effective treatment option for individuals with ASD, although further research is needed to fully understand the optimal treatment strategy and therapeutic potential.…”
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Treatment of anxiety disorders in clinical practice: a critical overview of recent systematic evidence by Vitor Iglesias Mangolini, Laura Helena Andrade, Francisco Lotufo-Neto, Yuan-Pang Wang

“…The aim of this study was to review emerging evidence of novel treatments for anxiety disorders. We searched PubMed and EMBASE for evidence-based therapeutic alternatives for anxiety disorders in adults, covering the past five years. …”
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The Personalised Randomised Controlled Trial (PRACTical): evaluation of a new trial design by Lee, KM, Turner, RM, Thwaites, GE, Walker, AS, White, IR

“…Here we use simulation to assess several novel analysis approaches for this innovative trial design. …”

Phase II study of vinflunine in malignant pleural mesothelioma. by Talbot, D, Margery, J, Dabouis, G, Dark, G, Taylor, H, Boussemart, H, Cadic, V, Pinel, M, Rivière, A, Ollivier, L, Ruffié, P

“…This study reports the clinical efficacy data for vinflunine, a novel microtubule inhibitor, in MPM. PATIENTS AND METHODS: Patients with a histologically confirmed diagnosis of MPM were eligible for enrollment onto this multicenter phase II trial if they had not received prior chemotherapy or radiotherapy and had measurable lesions by Response Evaluation Criteria in Solid Tumors (RECIST) criteria. …”

Thirteen years since the first iPhone: A systematic review on the effectiveness of language learning apps on smart devices by Huang, Z

“…<p>Powered by advanced calculating power and novel technologies like artificial intelligence, smartphone apps offer unprecedent creative solutions in education. …”

Cost-Effectiveness of Poly ADP-Ribose Polymerase Inhibitors in Cancer Treatment: A Systematic Review by Vivien Kin Yi Chan, Runqing Yang, Ian Chi Kei Wong, Ian Chi Kei Wong, Ian Chi Kei Wong, Xue Li, Xue Li, Xue Li, Xue Li

“…Additional economic evaluations are anticipated for novel indications.…”
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Network Visualization and Pyramidal Feature Comparison for Ablative Treatability Classification Using Digitized Cervix Images by Peng Guo, Zhiyun Xue, Jose Jeronimo, Julia C. Gage, Kanan T. Desai, Brian Befano, Francisco García, L. Rodney Long, Mark Schiffman, Sameer Antani

“…However, not all women are eligible for the therapy due to cervical characteristics. …”
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INFUSE: Rationale and design of a multi-center, open label, collaborative study to treat HRS-AKI with continuous terlipressin infusion by Ethan Weinberg, Suditi Rahematpura, Stevan A. Gonzalez, Manhal J. Izzy, Douglas A. Simonetto, R. Todd Frederick, Raymond A. Rubin, Jade Ikahihifo-Bender, Maggie Harte, Grace Kim-Lee, Sherry Witkiewicz, William Tobin, Khurram Jamil, Zachary Fricker, K. Rajender Reddy

“…The cohort will be enriched with those listed, in evaluation, or eligible for liver transplantation, while those with ACLF grade 3, MELD ≥35, and serum creatinine >5.0 mg/dL will be excluded. …”
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Obstructive Sleep Apnea Detection Based on Sleep Sounds via Deep Learning by Wang B, Tang X, Ai H, Li Y, Xu W, Wang X, Han D

“…In phase two, eligible patients were enrolled in a test group for algorithm assessment. …”
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Does High-Dose Thromboprophylaxis Improve Outcomes in COVID-19 Patients? A Meta-analysis of Comparative Studies by Maha A. T. Elsebaie, Binav Baral, Mai Elsebaie, Trilok Shrivastava, Catherine Weir, Dennis Kumi, Noah W. Birch

“…Background Thromboembolism remains a detrimental complication of novel coronavirus disease (COVID-19) despite the use of prophylactic doses of anticoagulation Objectives This study aimed to compare different thromboprophylaxis strategies in COVID-19 patients Methods We conducted a systematic database search until June 30, 2022. …”
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Evaluating a Smartphone App (MeT4VeT) to Support the Mental Health of UK Armed Forces Veterans: Feasibility Randomized Controlled Trial by Steven Parkes, Bethany Croak, Samantha K Brooks, Sharon A M Stevelink, Daniel Leightley, Nicola T Fear, Laura Rafferty, Neil Greenberg

“…ObjectiveA feasibility trial was conducted to assess a novel digital smartphone app (Mental Health Toolkit for Veterans Project [MeT4VeT]) for UK Armed Forces (UKAF) veterans experiencing mental health difficulties. …”
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European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 2: flunarizine by Christina I. Deligianni, Simona Sacco, Esme Ekizoglu, Derya Uluduz, Raquel Gil-Gouveia, Antoinette MaassenVanDenBrink, Raffaele Ornello, Margarita Sanchez-del-Rio, Uwe Reuter, Jan Versijpt, Tessa de Vries, Muizz Hussain, Dena Zeraatkar, Christian Lampl

“…Abstract Objective Novel disease-specific and mechanism-based treatments sharing good evidence of efficacy for migraine have been recently marketed. …”
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The effects of COVID-19 on European healthcare provision for working-age adults with major depressive disorder by Win Lee Edwin Wong, Dilveer Sually, Diego Hidalgo-Mazzei, Vinciane Quoidbach, Judit Simon, Patrice Boyer, Rebecca Strawbridge, Allan H. Young

“…This scoping review aimed to ascertain the impacts of COVID-19 on the delivery of MDD care in Europe, as well as to evaluate any novel MDD care strategies trialled in this period. …”
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The affordability of lecanemab, an amyloid-targeting therapy for Alzheimer's disease: an EADC-EC viewpoint by Linus Jönsson, Anders Wimo, Ron Handels, Gunilla Johansson, Mercè Boada, Sebastiaan Engelborghs, Lutz Frölich, Frank Jessen, Patrick Gavin Kehoe, Milica Kramberger, Alexandre de Mendonςa, Pierre Jean Ousset, Nikolaos Scarmeas, Pieter Jelle Visser, Gunhild Waldemar, Bengt Winblad

“…Disparities in access to novel amyloid-targeting agents may further deepen the inequalities across Europe in health outcomes. …”
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Late diagnosis of human immunodeficiency virus infection is linked to higher rates of epilepsy in children in the Eastern Cape of South Africa by Isabel A. Michaelis, Maryke Nielsen, Craig Carty, Markus Wolff, Caroline A. Sabin, John S. Lambert

“…In addition, our study demonstrates that novel techniques are effective in accessing cohort-level data that allow interrogation of both structured and unstructured clinical data.…”
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Multiple-model machine learning identifies potential functional genes in dilated cardiomyopathy by Lin Zhang, Yexiang Lin, Kaiyue Wang, Lifeng Han, Xue Zhang, Xiumei Gao, Zheng Li, Houliang Zhang, Jiashun Zhou, Heshui Yu, Xuebin Fu, Xuebin Fu

“…However, it has limitation for single algorithm to explore the diagnosing value of dilated cardiomyopathy (DCM). We aim to develop a novel overall normalized sum weight of multiple-model MLs to assess the diagnosing value in DCM.MethodsGene expression data were selected from previously published databases (six sets of eligible microarrays, 386 samples) with eligible criteria. …”
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Randomized Trial to Improve Primary Care Patient Management and Patient Outcomes Using a Drug–Drug Interaction Test: Confirmation of the DECART Simulated Patient Clinical Utility T... by John Peabody, Joshua Schrecker, Rebecca Heltsley, David Paculdo, Enrico de Belen, Diana Tamondong-Lachica, M. Czarina Acelajado, Othman Ouenes, Trina Kennedy, Elaine Jeter

“…We conducted a second prospective randomized, controlled trial to further establish the real-world clinical utility of a novel assay that objectively identifies potentially serious DDIs in real-world patients. …”
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Fibroblast growth factor receptors as targets for anticancer therapy in cholangiocarcinomas and urothelial carcinomas by Demi Wekking, Andrea Pretta, Serafina Martella, Alessandra Pia D'Agata, Joanna Joeun Choe, Nerina Denaro, Cinzia Solinas, Mario Scartozzi

“…These histotypes exhibit a high rate of multiple fibroblast growth factor receptor (FGFR) genetic alterations and numerous preclinical and clinical studies support FGFR as a highly attractive novel therapeutic target. Moreover, identifying specific genetic alterations may predict the tumor's response to conventional and novel FGFR-targeted drugs. …”
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