Health-related quality of life among people participating in a metabolic syndrome e-screening program: A web-based study by Leila Jahangiry, Davoud Shojaeezadeh, Ali Montazeri, Mahdi Najafi, Kazem Mohammad

“…However, the potential of novel web-based studies for MetS and online assessing of the quality of life (QOL) for these high-risk participants have not been explored. …”
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Improving resource utilisation in SLE drug development through innovative trial design by Joan T Merrill, Kenneth Kalunian, Sandra Garces, Anca D Askanase, Elaine Karis, May Mo, Cassandra E Milmont

“…Numerous clinical trials designed to investigate novel therapies are actively enrolling patients straining limited resources and creating inefficiencies that increase enrolment challenges. …”
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Protocol for a qualitative study exploring the lived experience of hearing loss and patient reported experience in the UK: the HeLP study by Amanda Hall, Helen Pryce, Rachel Shaw, Jonathan Banks, Georgina Burns-O'Connell, Rosemary Greenwood, Rebecca Knibb, Jean Straus, Sian Karen Smith, Saira Hussain

“…The aim of this qualitative study is to develop a novel theory of people’s lived experience of hearing loss across the lifespan.Methods Eligible participants will be young people and adults aged 16 years and above who have a hearing loss and carers/family members of people with a hearing loss. …”
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Simplified Clinical Decision Rule Using Clinically Important Events for Risk Prediction in Pediatric Head Injury: A Retrospective Cohort Study by Naoki Yogo, Chiaki Toida, Takashi Muguruma, Masayasu Gakumazawa, Mafumi Shinohara, Ichiro Takeuchi

“…In total, 59 (9%) patients showed ciTBI, and 129 (20%) were admitted to hospital. The novel CDR comprised six predictors of abnormal CT findings. …”
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Implementation of eHealth to Support Assessment and Decision-making for Residents With Dementia in Long-term Care: Systematic Review by Juliet Gillam, Nathan Davies, Jesutofunmi Aworinde, Emel Yorganci, Janet E Anderson, Catherine Evans

“…It requires an emphasis on the needs of residents and the engagement of end users in the implementation process. A novel conceptual model of the key factors was developed and translated into 18 practical recommendations on the implementation of eHealth in long-term care to guide implementers or innovators in care homes. …”
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157 Evaluating Interest in Clinical Trial Participation for the Treatment of Pediatric Food Allergy by Perry A. Catlin, Amy Van Hecke, Amal Assa’ad, Ruchi Gupta

“…Clinical trials (CT) are used to test novel treatments for FA. This project will evaluate the influence of biopsychosocial factors on interest in CT participation for pediatric FA. …”
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Association between increased systemic immune-inflammation index and postoperative delirium in older intertrochanteric fracture patients by Xiaoxiao Yan, Jin Huang, Xiachan Chen, Mian Lin

“…Finally, we created a novel nomogram for predicting POD in older patients with intertrochanteric fractures. …”
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MUKtwelve protocol: a phase II randomised, controlled, open, parallel group, multicentre trial of selinexor, cyclophosphamide and prednisolone (SCP) versus cyclophosphamide and pre... by Andrew Hall, Sarah Brown, Sadie Roberts, Martin Kaiser, Kevin Boyd, Jessica Kendall, Holger W Auner, Mamta Garg

“…Thus, there is a need for novel effective combination therapies with acceptable toxicity profiles.Ethics and dissemination Ethics approval is obtained. …”
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Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding by Ivana I. Jevtić, Thu Hang Lai, Jelena Z. Penjišević, Sladjana Dukić-Stefanović, Deana B. Andrić, Peter Brust, Sladjana V. Kostić-Rajačić, Rodrigo Teodoro

“…Although our results revealed that the novel fluorinated cinnamylpiperazines <b>8</b>–<b>17</b> do not possess sufficient MAO-B binding affinity to be eligible as positron emission tomography (PET) agents, the herein developed binding assay and the insights gained within our docking studies will certainly pave the way for further development of MAO-B ligands.…”
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The value of serum CA125 for the development of virtual follow-up strategies for patients with epithelial ovarian cancer: a retrospective study by Varughese Elizabeth, Kondalsamy-Chennakesavan Srinivas, Obermair Andreas

“…</p> <p>Conclusions</p> <p>The present paper proposes the validation of a novel CA125 algorithm aiming to detect recurrent EOC. …”
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Enfortumab vedotin and pembrolizumab as monotherapies and combination treatment in locally advanced or metastatic urothelial carcinoma: A narrative review by Maria A. Bantounou, Josip Plascevic, Lewis MacDonald, Man Chun Wong, Neasa O'Connell, Helen F. Galley

“…Positive preliminary results for pembrolizumab and EV combination therapy have led to FDA approval in patients with locally advanced or metastatic UC who are not eligible for platinum chemotherapy. Conclusions. Pembrolizumab and EV represent novel treatment options for patients with locally advanced or metastatic UC with documented superior outcomes and tolerability as compared with standard chemotherapy.…”
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Treating intrusive memories after trauma in healthcare workers: a Bayesian adaptive randomised trial developing an imagery-competing task intervention by Ramineni, V, Millroth, P, Iyadurai, L, Jaki, T, Kingslake, J, Highfield, J, Summers, C, Bonsall, M, Holmes, E

“…To address the urgent need to develop novel mental health interventions, we used Bayesian statistical approaches to optimise a brief imagery-competing task intervention to reduce the number of IMs. …”

HYDration and bicarbonate to prevent acute renal injury after endovascular aneurysm repair with suprarenal fixation: pilot/feasibility randomized controlled study (HYDRA pilot tria... by Saratzis, A, Chiocchia, V, Jiffry, A, Hassanali, N, Singh, S, Imray, C, Bown, M, Mahmood, A

“…</p><p><b>Methods:</b> We devised a novel AKI prevention strategy for EVAR based on best evidence and an expert consensus-group. …”

Meta-Analysis of In-Vitro Bonding of Glass-Ionomer Restorative Materials to Primary Teeth by Tamara Peric, Evgenija Markovic, Dejan Markovic, Bojan Petrovic

“…However, there is a lack of studies that examine the properties of novel GI formulations.…”
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The perceived impact of the Covid-19 pandemic on medical student education and training – an international survey by TMS Collaborative

“…Results A total of 1604 eligible participants from 45 countries took part in this survey and 56.3% (n = 860) of these were female. …”
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122 Evaluating the impact of the Translational Research Program at the University of Toronto by Samuel Neumark, Janine Noorloos, Joseph Ferenbok

“…Participants will be recruited through convenience sampling via email, social media platforms, and personal communication. Eligible participants must have a conferred Master of Health Science in Translational Research from the University of Toronto. …”
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Janus-kinase Inhibitors in Pathogenesis and Management of Chronic Urticaria: A Review of the Literature by Sepideh Darougar, Seyed Karen Hashemitari, Sara Montazeri Namin

“…Objectives: This review was conducted to focus on the Janus kinase (JAK) pathway, evaluate its role as a new biomarker, and discover the efficacy of its inhibitors as novel therapeutic agents in the treatment of refractory chronic urticaria. …”
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Hyposmia in COVID-19: Temporal Recovery of Smell: A Preliminary Study by Barbara Verro, Giulia Vivoli, Carmelo Saraniti

“…<i>Materials and Methods</i>: A prospective observational study was conducted on not hospitalized COVID-19 patients, selected according to eligible criteria. The study was approved by the Ethical Committee. …”
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Crediting temporary forest carbon: Retrospective and empirical perspectives on accounting options by Christopher S. Galik, Justin S. Baker, Adam Daigneault, Gregory Latta

“…We conclude with a presentation of our quantitative findings in the context of the existing literature, while also highlighting unmet research needs on these so-called new offsets, those emerging novel approaches for forest carbon mitigation that challenge the research and practice status quo.…”
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Effects of Cryogenic Storage on Human Amnion Epithelial Cells by Raghuraman C. Srinivasan, Stephen C. Strom, Roberto Gramignoli

“…Since multipotent cells are readily available from full-term placenta, this novel cell source might significantly increase the number of patients eligible to receive cellular therapies for liver and other diseases.…”
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