Tumor Microenvironment and Immunotherapy-Based Approaches in Mantle Cell Lymphoma by Khalil Saleh, Morgane Cheminant, David Chiron, Barbara Burroni, Vincent Ribrag, Clémentine Sarkozy

“…High-dose cytarabine-based regimens offer a durable response, but an important number of MCL patients are not eligible for intensive treatment and are ideal candidates for novel targeted therapies (such as BTK, proteasome or BCL2 inhibitors, Immunomodulatory Drugs (IMiDs), bispecific antibodies, or CAR-T cell therapy). …”
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Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases by Xu Jingyun, Qian Qiuping, Ren Mulan, Shen Yang

“…Laparoendoscopic single-site surgery (LESS) has become a novel minimally invasive approach applied as an option to perform hysterectomy. …”
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Pretreatment Pan-Immune-Inflammation Value Efficiently Predicts Survival Outcomes in Glioblastoma Multiforme Patients Receiving Radiotherapy and Temozolomide by Erkan Topkan, Ahmet Kucuk, Ugur Selek

“…The outcomes of 204 newly diagnosed GBM patients were analyzed retrospectively. Each eligible patient’s PIV was calculated using the findings of peripheral blood platelet (P), monocyte (M), neutrophil (N), and lymphocyte (L) counts obtained on the first day of therapy: PIV=P×M×N÷L. …”
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Stereotactic body radiotherapy in lung cancer: a contemporary review by Emese Csiki, Emese Csiki, Mihály Simon, Judit Papp, Márton Barabás, Márton Barabás, Johanna Mikáczó, Johanna Mikáczó, Kristóf Gál, David Sipos, Árpád Kovács

“…The purpose of this study is to summarize the current developments, randomised studies, guidelines about lung SBRT, with emphasis on the possibility of increasing local control and overall rates in “fit,” operable patients as well, so SBRT would be eligible in place of surgery.…”
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Early versus late intervention in patients with high-risk non-‘ST’-elevation myocardial infarction by Emmanuel Louka Aziz, Mohamed Abbas Morsy

“…Introduction With improvements in percutaneous coronary intervention and the advent of novel adjunctive pharmacotherapy agents (such as GP 2b/3a inhibitors, new antiplatelet agents, and intensive statin regimens), the safety and efficacy of early Percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) has improved significantly (1). …”
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The C4EB study-Transvamix (10% THC / 5% CBD) to treat chronic pain in epidermolysis bullosa: A protocol for an explorative randomized, placebo controlled, and double blind interven... by Nicholas H B Schräder, José C Duipmans, Remco J Renken, Peter Sörös, Karin M Vermeulen, Maria C Bolling, André P Wolff

“…Adequate symptom alleviation is not often achieved using conventional pharmacologic interventions. Finding novel approaches to pain care in EB is imperative to improve the quality of life of patients living with EB. …”
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Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis by Mohamad Ayub Khan Sharzehan, Hilary Sito, Noraidatulakma Abdullah, Athanasios Alexiou, Marios Papadakis, Rahman Jamal, Shing Cheng Tan

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Addressing the Barriers to Clinical Trials Accrual in Community Cancer Centres Using a National Clinical Trials Navigator:A Cross-Sectional Analysis by Caroline Hamm MD, Dora Cavallo-Medved PhD, Devinder Moudgil PhD, Lee McGrath, John Huang, Yueyang Li, Tyler W. Stratton, Tyler Robinson, Krista Naccarato, Stephen Sundquist, Janet Dancey

“…The median time from referral to death was 109 days in those that passed. Conclusion This novel navigator pilot has the potential to increase patient accrual to clinical trials. …”
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Effectiveness of an App-Based Mobile Intervention for Precision Oral Self-Care in Patients with Periodontitis from Initial Therapy to Re-Evaluation by Wen-Jen Chang, Yen-Li Wang, Yen-Hsiang Chang, Shih-Yin Lo

“…This study aims to investigate the intervention effectiveness of a novel mobile app for precision oral self-care, which was developed to help patients with periodontitis improving their oral hygiene through daily oral self-care. …”
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Machine learning analysis of the UK Biobank reveals IGF-1 and inflammatory biomarkers predict Parkinson's disease risk. by Michael Allwright, Hamish Mundell, Greg Sutherland, Paul Austin, Boris Guennewig

“…Our results suggest that novel risk biomarkers, including elevated IGF-1 and NLR, may play a role in, or are indicative of PD pathomechanisms. …”
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HIV prevalence and associated risk factors among individuals aged 13-34 years in Rural Western Kenya. by Pauli N Amornkul, Hilde Vandenhoudt, Peter Nasokho, Frank Odhiambo, Dufton Mwaengo, Allen Hightower, Anne Buvé, Ambrose Misore, John Vulule, Charles Vitek, Judith Glynn, Alan Greenberg, Laurence Slutsker, Kevin M De Cock

“…Further research on circumstances around HIV acquisition in young women and novel prevention strategies (vaccines, microbicides, pre-exposure prophylaxis, HSV-2 prevention, etc.) are urgently needed.…”
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Sustaining Talent: Reducing Employee Turnover at Tax Authority through Value Proposition and Social Identity by Andy Taufan, Riani Rachmawati

“…This study is particularly novel as it analyzes turnover intention among employees in a government institution, whereas prior studies have predominantly focused on the private sector. …”
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Understanding the identity of lived experience researchers and providers: a conceptual framework and systematic narrative review by Veenu Gupta, Catrin Eames, Laura Golding, Beth Greenhill, Robert Qi, Stephanie Allan, Alison Bryant, Peter Fisher

“…Out of the 2049 yielded papers, thirteen qualitative papers were eligible and synthesised, resulting in a conceptual framework. …”
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Advances in cryptographic voting systems by Adida, Benjamin (Benjamin Michael), 1977-

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Index of microcirculatory resistance at the time of primary percutaneous coronary intervention predicts early cardiac complications: insights From the OxAMI (Oxford Study in Acute... by Fahrni, G, Wolfrum, M, De Maria, G, Cuculi, F, Dawkins, S, Alkhalil, M, Patel, N, Forfar, J, Prendergast, B, Choudhury, R, Channon, K, Banning, A, Kharbanda, R

“…In total, 261 patients undergoing PPCI who were eligible for coronary physiology assessment were prospectively enrolled. …”

Measurement properties of radiographic outcome measures in Psoriatic Arthritis: A systematic review from the GRAPPA-OMERACT initiative by Antony, A, Holland, R, D'Agostino, M-A, Maksymowych, WP, Bertheussen, H, Schick, L, Goel, N, Ogdie, A, Orbai, A-M, Højgaard, P, Coates, LC, Strand, V, Gladman, DD, Christensen, R, Leung, YY, Mease, P, Tillett, W

“…Two reviewers assessed the methodology and results of eligible studies and synthesized the evidence using OMERACT methodology. …”

Gallstone disease and the risk of type 2 diabetes. by Lv, J, Yu, C, Guo, Y, Bian, Z, Yang, L, Chen, Y, Li, S, Huang, Y, Fu, Y, He, P, Tang, A, Chen, J, Chen, Z, Qi, L, Li, L

“…The present study highlights the importance of developing a novel prevention strategy to mitigate type 2 diabetes through improvement of gastrointestinal health.…”

Modifiable predictors of depression following childhood maltreatment: A systematic review and meta-analysis by Braithwaite, E, O’Connor, R, Degli-Esposti, M, Luke, N, Bowes, L

“…Corroboration and further investigation of causal mechanisms is required to identify novel targets for intervention, and to inform guidelines for the effective treatment of maltreated children.…”

Evaluation of Antitumor Activity Using Change in Tumor Size of the Survivin Antisense Oligonucleotide LY2181308 in Combination with Docetaxel for Second-Line Treatment of Patients... by Natale, R, Blackhall, F, Kowalski, D, Ramlau, R, Bepler, G, Grossi, F, Lerchenmüller, C, Pinder-Schenck, M, Mezger, J, Danson, S, Gadgeel, S, Summers, Y, Callies, S, André, V, Das, M, Lahn, M, Talbot, D

“…We used change in tumor size (CTS) as a primary endpoint to assess its use in early decision-making for this and future studies of novel agents in NSCLC. Patients (N = 162) eligible for second-line NSCLC treatment (stage IIIB/IV) with an Eastern Cooperative Oncology Group performance status of 0 to 1 were randomized 2:1 to receive LY2181308 (750 mg intravenously, weekly) and docetaxel (75 mg/m2 intravenously, day 1) or docetaxel alone every 21 days. …”

Development and evaluation of a risk prediction tool for risk-adapted screening of colorectal cancer in China by Hang, D, Sun, D, Du, L, Huang, J, Li, J, Zhu, C, Wang, L, He, J, Zhu, X, Zhu, M, Song, C, Dai, J, Yu, C, Xu, Z, Li, N, Ma, H, Jin, G, Yang, L, Chen, Y, Du, H, Cheng, X, Chen, Z, Lv, J, Hu, Z, Li, L, Shen, H

“…In conclusion, we developed a novel risk prediction tool that is useful to identify individuals at high risk of CRC. …”