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461
Tumor Microenvironment and Immunotherapy-Based Approaches in Mantle Cell Lymphoma
Published 2022-06-01“…High-dose cytarabine-based regimens offer a durable response, but an important number of MCL patients are not eligible for intensive treatment and are ideal candidates for novel targeted therapies (such as BTK, proteasome or BCL2 inhibitors, Immunomodulatory Drugs (IMiDs), bispecific antibodies, or CAR-T cell therapy). …”
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462
Variations in sexual function after laparoendoscopic single-site hysterectomy in women with benign gynecologic diseases
Published 2023-07-01“…Laparoendoscopic single-site surgery (LESS) has become a novel minimally invasive approach applied as an option to perform hysterectomy. …”
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463
Pretreatment Pan-Immune-Inflammation Value Efficiently Predicts Survival Outcomes in Glioblastoma Multiforme Patients Receiving Radiotherapy and Temozolomide
Published 2022-01-01“…The outcomes of 204 newly diagnosed GBM patients were analyzed retrospectively. Each eligible patient’s PIV was calculated using the findings of peripheral blood platelet (P), monocyte (M), neutrophil (N), and lymphocyte (L) counts obtained on the first day of therapy: PIV=P×M×N÷L. …”
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464
Stereotactic body radiotherapy in lung cancer: a contemporary review
Published 2024-02-01“…The purpose of this study is to summarize the current developments, randomised studies, guidelines about lung SBRT, with emphasis on the possibility of increasing local control and overall rates in “fit,” operable patients as well, so SBRT would be eligible in place of surgery.…”
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465
Early versus late intervention in patients with high-risk non-‘ST’-elevation myocardial infarction
Published 2022-01-01“…Introduction With improvements in percutaneous coronary intervention and the advent of novel adjunctive pharmacotherapy agents (such as GP 2b/3a inhibitors, new antiplatelet agents, and intensive statin regimens), the safety and efficacy of early Percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) has improved significantly (1). …”
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466
The C4EB study-Transvamix (10% THC / 5% CBD) to treat chronic pain in epidermolysis bullosa: A protocol for an explorative randomized, placebo controlled, and double blind interven...
Published 2022-01-01“…Adequate symptom alleviation is not often achieved using conventional pharmacologic interventions. Finding novel approaches to pain care in EB is imperative to improve the quality of life of patients living with EB. …”
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467
Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis
Published 2022-11-01Get full text
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468
Addressing the Barriers to Clinical Trials Accrual in Community Cancer Centres Using a National Clinical Trials Navigator:A Cross-Sectional Analysis
Published 2022-09-01“…The median time from referral to death was 109 days in those that passed. Conclusion This novel navigator pilot has the potential to increase patient accrual to clinical trials. …”
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469
Effectiveness of an App-Based Mobile Intervention for Precision Oral Self-Care in Patients with Periodontitis from Initial Therapy to Re-Evaluation
Published 2021-05-01“…This study aims to investigate the intervention effectiveness of a novel mobile app for precision oral self-care, which was developed to help patients with periodontitis improving their oral hygiene through daily oral self-care. …”
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470
Machine learning analysis of the UK Biobank reveals IGF-1 and inflammatory biomarkers predict Parkinson's disease risk.
Published 2023-01-01“…Our results suggest that novel risk biomarkers, including elevated IGF-1 and NLR, may play a role in, or are indicative of PD pathomechanisms. …”
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471
HIV prevalence and associated risk factors among individuals aged 13-34 years in Rural Western Kenya.
Published 2009-07-01“…Further research on circumstances around HIV acquisition in young women and novel prevention strategies (vaccines, microbicides, pre-exposure prophylaxis, HSV-2 prevention, etc.) are urgently needed.…”
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472
Sustaining Talent: Reducing Employee Turnover at Tax Authority through Value Proposition and Social Identity
Published 2023-12-01“…This study is particularly novel as it analyzes turnover intention among employees in a government institution, whereas prior studies have predominantly focused on the private sector. …”
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473
Understanding the identity of lived experience researchers and providers: a conceptual framework and systematic narrative review
Published 2023-04-01“…Out of the 2049 yielded papers, thirteen qualitative papers were eligible and synthesised, resulting in a conceptual framework. …”
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474
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Index of microcirculatory resistance at the time of primary percutaneous coronary intervention predicts early cardiac complications: insights From the OxAMI (Oxford Study in Acute...
Published 2017“…In total, 261 patients undergoing PPCI who were eligible for coronary physiology assessment were prospectively enrolled. …”
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476
Measurement properties of radiographic outcome measures in Psoriatic Arthritis: A systematic review from the GRAPPA-OMERACT initiative
Published 2021“…Two reviewers assessed the methodology and results of eligible studies and synthesized the evidence using OMERACT methodology. …”
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477
Gallstone disease and the risk of type 2 diabetes.
Published 2017“…The present study highlights the importance of developing a novel prevention strategy to mitigate type 2 diabetes through improvement of gastrointestinal health.…”
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478
Modifiable predictors of depression following childhood maltreatment: A systematic review and meta-analysis
Published 2017“…Corroboration and further investigation of causal mechanisms is required to identify novel targets for intervention, and to inform guidelines for the effective treatment of maltreated children.…”
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479
Evaluation of Antitumor Activity Using Change in Tumor Size of the Survivin Antisense Oligonucleotide LY2181308 in Combination with Docetaxel for Second-Line Treatment of Patients...
Published 2014“…We used change in tumor size (CTS) as a primary endpoint to assess its use in early decision-making for this and future studies of novel agents in NSCLC. Patients (N = 162) eligible for second-line NSCLC treatment (stage IIIB/IV) with an Eastern Cooperative Oncology Group performance status of 0 to 1 were randomized 2:1 to receive LY2181308 (750 mg intravenously, weekly) and docetaxel (75 mg/m2 intravenously, day 1) or docetaxel alone every 21 days. …”
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480
Development and evaluation of a risk prediction tool for risk-adapted screening of colorectal cancer in China
Published 2024“…In conclusion, we developed a novel risk prediction tool that is useful to identify individuals at high risk of CRC. …”
Journal article